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Oral administration nano-drug administration system of resveratrol

A technology of resveratrol and drug delivery system, which is applied in the direction of digestive system, antineoplastic drugs, drug combination, etc., can solve the problems of poor absorption, etc., and achieve the effect of simple preparation method, good drug effect, and improved oral absorption

Active Publication Date: 2008-12-10
北大世佳科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Using wheat prolamin as a carrier material, nanotechnology is used to prepare resveratrol into a new oral drug delivery system to solve the problem of poor absorption. There is no literature report so far.

Method used

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  • Oral administration nano-drug administration system of resveratrol
  • Oral administration nano-drug administration system of resveratrol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Take 15mg of Pluronic F68, add 30ml of water to dissolve it as the water phase; take another 10mg of resveratrol and 100mg of wheat prolamin, add it to 10ml of 80% ethanol solution, stir to dissolve, and use it as the organic phase. Take the organic phase, quickly inject it into the water phase with a No. 5 needle, and continue to stir for 5 minutes. Move to a vacuum oven at 60°C, remove the ethanol, concentrate to contain 0.3mg of resveratrol per 1ml, and obtain the resveratrol oral nano drug delivery system.

[0024] The particle size of the resveratrol oral nano drug delivery system is 50-200nm, and the resveratrol encapsulation efficiency is 74.6%.

Embodiment 2

[0026] Take 30 mg of Tween-80, add 50 ml of water to dissolve it as the water phase; take another 10 mg of resveratrol and 50 mg of wheat prolamin, add it to 5 ml of 70% ethanol solution, stir to dissolve, and use it as the organic phase. Take the organic phase and quickly inject it into the water phase with a No. 5 needle, and continue stirring for 5 min. Move to 60°C vacuum oven (vacuum degree: 0.08mpa), remove ethanol, and concentrate to contain 0.3mg of resveratrol per 1mL. Adding sucrose and mannitol as a scaffolding agent, freeze-drying can obtain the resveratrol oral nano drug delivery system.

[0027] The particle size of the resveratrol oral nano drug delivery system is 50-200nm, and the resveratrol encapsulation efficiency is 71.5%.

Embodiment 3

[0029] Take 15 mg of Pluronic F68 and 15 mg of Tween-80, add 100 ml of water to dissolve it as the water phase; add 10 mg of resveratrol and 120 mg of wheat prolamin into 50 ml of 70% ethanol solution, stir to dissolve, and use it as the organic phase. Take the organic phase and quickly inject it into the water phase with a No. 5 needle, and continue stirring for 5 min. Move to 60°C vacuum oven (vacuum degree: 0.08mpa), remove ethanol, and concentrate to contain 0.30mg of resveratrol per 1ml. The resveratrol oral nano drug delivery system was obtained by freeze-drying.

[0030] The particle size of the resveratrol oral nano drug delivery system is 50-200nm, and the resveratrol encapsulation efficiency is 83.5%.

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Abstract

The invention relates to a resveratrol oral administration drug delivery system prepared through the nanometer technology. The drug delivery system is made of the resveratrol and bearer material of wheat gliadin. By utilizing the characteristic that the nanometer granule is highly dispersed and that of biological adhesion of the bearer material, the contact area and contact time of the resveratrol and absorption region of the intestinal canal is increased, which can promote absorption of the small intestine. In addition, the resveratrol oral administration nanometer drug delivery system is distributed over the suitable auxiliary-material skeletal material to improve the dissolve velocity and degree of the resveratrol.

Description

technical field [0001] The invention relates to a pharmaceutical dosage form and preparation technology, in particular to a resveratrol oral nano drug delivery system. Background technique [0002] Resveratrol (Resveratrol, Res) is a natural stilbene active substance, which is commonly found in commonly used traditional Chinese medicines such as Polygonum multiflorum, Polygonum cuspidatum and Canary, and has the functions of inhibiting platelet aggregation, antibacterial, anticancer and liver protection. Various biological effects. However, its low solubility in water and low absorption rate through the small intestine have seriously affected its wide application in the field of medicine. At present, no ideal pharmaceutical preparation of resveratrol has been developed. Therefore, it is of great significance to find and study pharmaceutical dosage forms with less toxic and side effects to improve the water solubility of resveratrol and improve its absorption in the small in...

Claims

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Application Information

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IPC IPC(8): A61K31/05A61K47/42A61P1/16A61P35/00
Inventor 周亚伟
Owner 北大世佳科技开发有限公司
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