Micro-fluidic chip stereo flow field velocity vector measurement method and system

A technology of a microfluidic chip and a measurement method, applied in the field of spectral domain optical coherence tomography and Doppler, can solve the problems of low spatial resolution, inability to transplant the flow field of the microfluidic chip, sacrificing imaging depth, etc. Achieving the effect of high precision, promotion promotion and low cost

Inactive Publication Date: 2008-12-31
ZHEJIANG UNIV
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Problems solved by technology

The current vector velocity measurement is mainly based on the spatial orientation of the vascular network, the spatial resolution is not high, and it cannot be transplanted into the measurement of the flow field of the microfluidic chip
The vector velocity measurement method based on the three-layer optical retarder proposed by Yeh-Chan Ahn et al recently sacrifices too much imaging depth, which is a major constraint factor for spectral domain OCT

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  • Micro-fluidic chip stereo flow field velocity vector measurement method and system
  • Micro-fluidic chip stereo flow field velocity vector measurement method and system
  • Micro-fluidic chip stereo flow field velocity vector measurement method and system

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Embodiment Construction

[0031] The present invention will be further described below in conjunction with the accompanying drawings and embodiments.

[0032] figure 1 Shown is a schematic structural diagram of the spectral domain OCT vector velocity measurement system. The low-coherence light emitted by the broadband light source 4 enters the broadband fiber coupler 7 after passing through the first polarization controller 5 and the isolator 6. Polarization controller 5 enters the reference and sample arms. After being collimated by the first collimating mirror 12, the light coming out from the reference arm fiber passes through the dispersion compensator 13 and the neutral filter 14 and is incident on the reflector 15, that is, the reference surface. The dispersion compensator 13 and the neutral filter The role of the sheet 14 is to match the dispersion and light intensity between the two arms respectively to ensure the best imaging quality. The reference light returned from the mirror 15 is coupled...

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Abstract

The invention discloses a measurement method and a system of flow velocity vector of a three-dimensional flow field of a microfluidic chip. The spectral domain optical coherence tomography technology (SD-OCT) is combined with the Doppler Effect, and a narrow-band phase plate is applied on the basis. The spectral domain OCT realizes the extraction of deep information of the flow field of the microfluidic chip through the parallel detection of Interference spectrum; compared with the conventional time-domain OCT, the imaging speed is greatly improved. The Doppler frequency shift and the Doppler broadening are comprehensively utilized, the narrow-band phase plate is inserted between a collimating mirror and a focusing lens of an imaging probe, thereby implementing the spatial encoding of the Doppler information, realizing the imaging requirements on the spatial high-resolution three-dimensional speed vector, combining with the Doppler OCT method which is based on the phase resolution technology to meet the high-speed and high-sensitivity measurement requirements and finally realizing the speed vector imaging with high-resolution, high-speed, high-sensitivity and large-imaging range of the three-dimensional flow field of the microfluidic chip.

Description

technical field [0001] The invention relates to spectral domain optical coherence tomography (SD-OCT) and Doppler technology, in particular to a method and system for measuring the velocity vector of the three-dimensional flow field of a microfluidic chip. Background technique [0002] Microfluidic chip is the cutting-edge technology of modern analytical science and the main research direction of Micro Total Analytical System (uTAS), which will have a revolutionary impact on the fields of life science, environmental science, medicine and chemistry. Since UC Berkeley realized high-speed DNA sequencing on microfluidic chips in 1995, it has been successfully applied to the detection of amino acids, proteins, cells, drugs, and trace elements, showing great application potential. [0003] The precise control of the flow field of the microfluidic chip is the key to the design of the microfluidic chip. The simulation parameters that can be included in the current design algorithm ...

Claims

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Application Information

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IPC IPC(8): G01P5/26
Inventor 丁志华朱瑛孟婕
Owner ZHEJIANG UNIV
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