Instant gel rubber of clonidine hydrochloric for eyes

A technology of clonidine hydrochloride and cola hydrochloride, which is applied in the field of medicine, can solve the problems of restricting the curative effect of clonidine hydrochloride eye drops, short retention time, large loss of eye drops, etc. Improve the effect of curative effect

Inactive Publication Date: 2009-01-14
肖正连
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Clonidine hydrochloride eye drops is a commonly used ophthalmic preparation, but clinically there is a large loss of eye drops inst

Method used

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  • Instant gel rubber of clonidine hydrochloric for eyes
  • Instant gel rubber of clonidine hydrochloric for eyes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Prescription: 2.5 grams of clonidine hydrochloride, 400 milliliters of hydrochloric acid (0.05mol / L)

[0024] Sodium Citrate 10.5g Methylcellulose 5.0g Phenylethyl Alcohol 0.5g

[0025] Ethanol 5ml Sodium Chloride 1.0g PEG-1000 20g

[0026] PEG-400 5g water for injection appropriate amount

[0027] Preparation method: Heat water for injection to boil, cool to 80°C, add clonidine hydrochloride, dissolve phenylethyl alcohol in ethanol, add dropwise to the above solution while stirring, add sodium citrate, stir for more than 30 minutes, and then add hydrochloric acid Stir, filter through a microporous membrane (0.22μm), heat the filtrate to 40°C, add sodium chloride, methylcellulose, PEG-1000 and PEG-400 while hot, stir to room temperature (18-25°C) , and add water for injection to make up the weight to 1000 ml, stir to form a uniform gel, and aseptically pack it.

Embodiment 2

[0029] Prescription: 2.5 grams of clonidine hydrochloride, 200 milliliters of sulfuric acid (0.05mol / L)

[0030] Sodium Citrate 10.5g Methylcellulose 5.0g Benzyl Alcohol 0.5g

[0031] Ethanol 5ml Sodium Chloride 2.0g PEG-1000 70g

[0032] Appropriate amount of water for injection

[0033] Preparation method: Heat water for injection to boil, cool to 80°C, add clonidine hydrochloride, dissolve benzyl alcohol in ethanol, add dropwise to the above solution while stirring, add sodium citrate, stir for more than 30 minutes, and then add sulfuric acid Stir, filter through a microporous membrane (0.22μm), heat the filtrate to 40°C, add sodium chloride, methylcellulose and PEG-1000 while hot, stir to room temperature (18-25°C), and then inject Make up the weight with water to 1000 ml, stir to make it form a uniform gel, and aseptically dispense it.

Embodiment 3

[0035] Prescription: 2.5 grams of clonidine hydrochloride, 200 milliliters of sodium hydroxide (0.1mol / L)

[0036] Boric acid 5.6g Methylcellulose 5.0g Sodium benzoate 0.5g

[0037] Ethanol 5ml Sodium Chloride 5.0g PEG-4000 100g

[0038] Appropriate amount of water for injection

[0039] Preparation method: heat and boil water for injection, cool to 80°C, add clonidine hydrochloride, sodium citrate, sodium hydroxide and sodium benzoate, stir for more than 30 minutes, then add boric acid and stir, pass through a microporous membrane (0.22 μm), the filtrate was heated to 40°C, PEG-4000 and methylcellulose were added while it was hot, stirred to room temperature (18-25°C), and water for injection was added to make up the weight to 1000 ml, and stirred to form a uniform Gel, aseptically dispensed.

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PUM

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Abstract

The invention discloses an immediate type ophthalmic gelatin of hydrochloric acid clonidine and a preparation method thereof. 100 milliliters of the immediate type ophthalmic gelatin of hydrochloric acid clonidine contains 1 to 5 grams of the hydrochloric acid clonidine, 0.05 to 1 gram of preservative, 1.0 to 7.5 grams of permeation pressure conditioning agent and 30 to 150 grams of gelatin substrate. Remaining components are acid-base buffer regent and water for rejection. The invention enriches the dosage forms of the hydrochloric acid clonidine by optimizing auxiliary materials and improving technology so that lag time in eyes is greatly prolonged and curative effect is improved without adverse stimulus reaction.

Description

【Technical field】 [0001] The invention belongs to the technical field of medicine, and in particular relates to a clonidine hydrochloride ophthalmic instant gel. 【Background technique】 [0002] Ophthalmic instant gel is also called ophthalmic in-situ gel or ophthalmic in-situ gel. Its preparation is liquid when placed at room temperature. Gel-like, it can stay in the eye for a long time, so as to prolong the treatment time, enhance the treatment effect and reduce the loss of medicine. [0003] Instant ophthalmic gel is not yet a very mature pharmaceutical preparation, and instant ophthalmic gel, which depends on the principles of temperature, pH value and ionic strength, is not yet mature in commercialization, because the dosage form is not only It requires fine technology, appropriate excipients, and the proper matching of drugs, processes and excipients in ophthalmic ready-to-use gels. Otherwise, it cannot be placed in a liquid state at room temperature, and it will be tr...

Claims

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Application Information

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IPC IPC(8): A61K31/4168A61K9/00A61K47/32A61K47/34A61K47/38A61P27/06A61K47/10
Inventor 肖正连
Owner 肖正连
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