Lornoxicam double-layer sustained release tablets

A technology of lornoxicam and sustained-release tablets, which is used in pharmaceutical formulations, pill delivery, non-central analgesics, etc. Problems such as low concentration and difficult treatment concentration
CN101342177BActive Publication Date: 2011-10-26CHINA PHARM UNIV +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
CHINA PHARM UNIV
Publication Date
2011-10-26

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Abstract

The invention relates to a double-layer sustained release lornoxicam tablet which comprises (a) a quick release layer and (b) a sustained release layer, wherein, the quick release layer comprises (a1) the lornoxicam, (a2) alkaline matter and (a3) an other optional carrier or pharmaceutically acceptable excipient and the sustained release layer comprises the (b1) lornoxicam, (b2) sustained releasesubstance and (b3) the other optional carrier or the pharmaceutically acceptable excipient. The weight proportion of (a1) and (b1) is 1:50 to 50:1. The invention also provides a preparation method ofthe double-layer sustained release lornoxicam tablet. The double-layer sustained release preparation of the invention has the advantages of the quick effect of the quick release preparation and the sustained effect of sustained release preparation. In addition, the double-layer sustained release preparation can maintain the effect of effective blood concentration continuously and stably after theeffective blood concentration is reached rapidly.
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Description

technical field

[0001] The invention belongs to the technical field of pharmaceutical preparations, in particular to a double-layer sustained-release tablet of a non-steroidal anti-inflammatory drug lornoxicam and a preparation method thereof. Background technique

[0002] Lornoxicam (Lornoxicam) is a non-steroidal anti-inflammatory drug of Oxycam, the chemical name is 6-chloro-4-hydroxy-2-methyl-3-N-(2-pyridyl)-2H-phenothia And[2,3-e]-1,2-thiazine-3-carboxamide-1,1-dioxide. Lornoxicam has good analgesic and anti-inflammatory effects, and the currently marketed dosage forms include film-coated tablets and freeze-dried powder injections.

[0003] Due to the short half-life of lornoxicam in vivo, in order to maintain the effective blood concentration, clinical oral administration of lornoxicam film-coated tablets requires repeated administration, and multiple tablets need to be taken each time, which brings inconvenience to the clinical medication of patients, and due to bloo...

Claims

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