Use of pentacyclic triterpene saponin compound

A technology of pentacyclic triterpene saponins and compounds, which is applied in the field of medicine and can solve problems such as elevated transaminases

Active Publication Date: 2009-01-14
安士制药(中山)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are not many drugs on the market that effectively control blood lipids and have few side effects. Commonly used western drugs are clofibrate esters such as fenofibrate, and oxyacetic acids such as lovastatin. These drugs have more side effects, most of which are harmful to the liver. There are effects, such as fenofibrate can cause transaminase elevation, etc. (see fenofibrate capsule instructions)

Method used

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  • Use of pentacyclic triterpene saponin compound
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  • Use of pentacyclic triterpene saponin compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1 Preparation of Peltatin Glucoside and Salicylic Acid

[0036] Rescue 20Kg of Bing medicinal material (Ilex rotunda Thunb.) and extract with 95% ethanol, concentrate the extract to 5.6Kg, add 16Kg of water, filter, take the insoluble matter (precipitate) to obtain a crude extract, this extract is dispersed with silica gel Afterwards, in a Sabouraud extractor, first extract with dichloromethane under heating and reflux, and recover the solvent to save the crude Bing acid, and then recrystallize with dichloromethane to save the Bing acid. The content is 98.8% (determined by high performance liquid chromatography). ); The residue in the Sabouraud extractor was heated and refluxed with ethyl acetate to extract the solvent to obtain the crude cinnamon glycoside. The product was recrystallized with 60% ethanol to obtain the cinnamon glycoside with a content of 99.2% (using Measured by high performance liquid chromatography).

Embodiment 2

[0037] Example 2. Take 310g of cinnamon glucoside, grind into fine powder, add about 150g of 20% starch paste, mix, granulate with 14 mesh sieve, dry at 100°C, granulate, add 20g starch, 2g magnesium stearate, Mix well, press into 1000 tablets, and get ready. Each tablet weighs 0.35g and contains 300±5mg of Peltatin Glycoside.

Embodiment 3

[0038] Example 3. Rescue 260g of Bing acid, grind into fine powder, add about 150g of 20% starch paste, mix, granulate with 14 mesh sieve, dry at 100°C, granulate, add 20g starch, 2g magnesium stearate, Mix well, press into 1000 tablets, and get ready. Each tablet weighs 0.3g and contains 250±5mg of salvage acid.

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Abstract

The usage of a pentacyclic triterpenoid saponins compound relates to the filed of medicines, in particular to a pentacyclic triterpenoid saponins compound for preparing lipid-lowering medicines. The pentacyclic triterpenoid saponins refers to the compound in the right formula: R is H or Beta-D-glucosyl; the structural formula of Beta-D-glucosyl is the right formula.

Description

Technical field [0001] The invention relates to the field of medicine, in particular to a pentacyclic triterpenoid compound used for preparing a medicine for lowering blood lipids. Background technique [0002] Chinese medicinal material Jiu Bing is the dry bark of Ilex rotunda Thunb. It is widely distributed in southern China and mainly produced in Guangxi and Guangdong provinces. It is commonly used by folks to clear away heat and detoxify, relieve swelling and relieve pain, and treat colds and fevers. , Acute and chronic hepatitis, acute gastroenteritis, gastric and duodenal ulcer, rheumatic joint pain. There are not many reports on the chemical composition of Jiubiying. In the literature "Research on the Chemical Composition of Jiubiying" (Chinese Herbal Medicine, 1991, 22(6): 246-248), it is reported that the iron-containing holly acid in Jiubiying (Jiubing (Acid acid), Peltatin Glycoside, Iso-Isoside ketal, Syringin, Sinalin, Sinalin Glucoside, Syringaldehyde, 3-acetylolean...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61K31/7024A61P3/06
Inventor 刘国樵
Owner 安士制药(中山)有限公司
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