Extraction method for preparing high-purity allocryptopine

Abstract

The invention relates to a method for preparing and extracting high-purity allocryptopine. An initial extract is obtained by making use of ethanol to carry out refluxing, extraction and drying by distillation on natural papaveraceae plant; most alkaloid of the initial extract is subsided out in acidity alcohol, the pH value of the solution is adjusted to 7.5-8.5 by sig water and then to 9.5-10.5 after filtration, filtration is carried out again and filter residue is a crude extract; the crude extract is carried out refluxing treatment by ethyl acetate and methanol and filtered; the high-content allocryptopine monomer is obtained after the recrystallization of residue obtained from the filtrate by decompression and drying by distillation in methanol or chloroform-methanol or anhydrous alcohol. The method expands the scale of raw materials for extracting allocryptopine and provides a new economic and feasible way for preparing high-purity allocryptopine monomer. The method applies raw materials which are available, has simple and easy separation and purification technique and relatively low cost and is suitable for mass production.

Description

A kind of extraction method for preparing high-purity allocryptopine technical field The invention belongs to a method for extracting effective components of natural products, and mainly relates to a method for extracting and separating active monomeric alkaloids from natural plants, in particular to a method for separating and preparing high-purity alkaloids from the traditional Chinese medicine Boluohui. Background technique Allocryptopine (Allocryptopine) is mainly extracted and isolated from plants such as Papaveraceae (such as Boluohui, Xueshuicao, Celandine, etc.), or obtained by chemical synthesis. Its pharmacological effect is mainly antiarrhythmic effect, and its inhibitory effect on animal arrhythmia caused by aconitine is greater than that of nicotinamine; it can prevent animal myocardial potassium deficiency caused by aconitine; when intravenous injection of 10mg / kg, it can prevent electrical stimulation. animals with atrial fibrillation. It has strong antibac...

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Problems solved by technology

The document "Research on the Active Components in the Fruit of Boluohui" (Hu Zhibi et al., "Acta Pharmaceutica Sinica" 1979, 14 (9), 535-539) separated sanguinarine and chelerythrine through a silica gel column and also obtained the Alkaline monomer, but the cost is high, the yield is low, only suitable for a small amount of production, not suitable for industrial production

After searching, there is no patent literature report on the industrial production method of preparing allocryptine monomer at home and abroad

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