Preparation method for salinomycin sodium fine granular formulation

A salinomycin sodium and micro-particle technology, applied in the directions of additional food elements, animal feed molding or processing, animal feed, etc., can solve problems such as unfavorable production costs and product quality, affecting the health of operators, and easily generating dust. , to avoid insufficient or excessive intake of food, which is beneficial to mixing and uniform feeding

Active Publication Date: 2011-03-30
山东齐发药业有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition to producing powdered salinomycin sodium premix, dust is easily generated during the production process, which affects the health of operators, and it is gradually eliminated with the promotion of pellet feed
The method of CN1631365, although can adapt to market demand and produce granular salinomycin sodium, complex procedure, long production cycle, unfavorable to production cost and product quality

Method used

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  • Preparation method for salinomycin sodium fine granular formulation
  • Preparation method for salinomycin sodium fine granular formulation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1. The total amount of salinomycin and the content of dry matter in the fermented liquid are 13%wt.

[0025] The titer of salinomycin fermentation broth is 65000 μg / mL, take 200L, add 65Kg calcium carbonate, 0.4Kg hydroxymethyl cellulose, add caustic soda to adjust pH, measure pH while adding, adjust to pH7.5 and stop adding alkali. The feed liquid is pressurized by the screw pump and enters the spray gun. The nozzle of the spray gun adopts a 1.8mm aperture spray piece. The liquid droplets exchange water with the hot air flowing upstream and quickly dry into tiny particles. The particles enter the vibrating screen and collect the middle layer to obtain salt. 98Kg semi-finished product of mycin sodium microparticles. Tested content: 121 μg / mg, particle size: 100% passed No. 2 drug sieve, 12% passed No. 5 drug sieve.

[0026] After sieving, the semi-finished product of salinomycin sodium microparticles is sent to a powder mixer, and mixed with semi-finished pr...

Embodiment 2

[0028] After the fermentation, the titer of the salinomycin fermentation broth was 70000 μg / mL, 200 L was taken, 70 Kg calcium carbonate, 0.4 Kg hydroxymethyl cellulose were added, and caustic soda was added to adjust the pH to 7.4 to stop adding alkali. Spray drying is the same as in Example 1 to obtain 103Kg of semi-finished product. Tested content: 122 μg / mg, particle size: 100% passed No. 2 drug sieve, 13% passed No. 5 drug sieve.

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Abstract

The invention relates to a method for preparing salinomycin sodium micro-granules, which comprises the steps of feed liquid preparation, spray drying and powder mixing packaging. A feed liquid is prepared by adding sodium hydroxide, calcium carbonate and a small quantity of carboxy methyl cellulose into a zymotic fluid to ensure that the pH value of the zymotic fluid is alkaline and contributes to the stability of the intermediate process and a final product, the feed liquid enters a spraygun through the pressure increase of a screw pump, and only a few seconds are spent to convert liquid drops into granules, thereby avoiding the pasting of materials and the production of substances containing toxic side effect at high temperature for a long time. The salinomycin sodium micro-granules prepared by the method are even and regular, thereby being mixed with feedstuff easily during the application, ensuring that animals have even and effective food intake, and avoiding the phenomenon that beasts and birds fail to intake or intake overmuch.

Description

technical field [0001] The invention relates to a preparation method of an antibiotic premix, in particular to a salinomycin sodium microparticle and a preparation method thereof. Background technique [0002] At present, the preparation of antibiotic premix and pure salinomycin sodium generally adopts solvent extraction method, spray drying method, and plate-and-frame filtration method. Sodium, take the salinomycin fermentation liquid, heat it through alkalization, separate and concentrate, use calcium carbonate as the excipient, and use the method of spray drying to directly dry the salinomycin mycelium to obtain feed grade salinomycin with different contents. The finished product is light yellow-brown uniform powder. Chinese patent CN1230596 (98106302.0) cultivates salinomycin-producing bacteria in a carbon source based on high-concentration vegetable oil. After the cultivation, it is treated with lye, and then filter aid is added. Then, after maintaining a certain tempe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A23K1/165A23K20/195A23K40/10
Inventor 张效军张德凯周荣财
Owner 山东齐发药业有限公司
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