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Donkey-hide gelatin effervescent particle and preparation method thereof

A technology of effervescent granules and donkey-hide gelatin, which is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, and bulk transportation, can solve the problems of low labor productivity, complicated process operations, inconsistent particle colors, etc., and achieves improved labor productivity, Simple operation process, uniform color effect

Active Publication Date: 2009-04-08
SHANDONG HUAXIN PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] In the patent number: 90106302.9, the patent name is "Preparation Process of Ejiao Effervescent Granules", which adopts two-step granulation method, that is, acid granulation method and alkali granulation method. The process operation is very complicated and the labor productivity is low; Wet agent has poor adhesion, more fine powder, and lower yield of finished products; because acid granules and alkali granules are used to granulate separately, the final mixed granules have inconsistent colors, and the product appearance is poor, which is not easy for customers to accept ;Because the acid and base are in different particles, the acid and base cannot react quickly to produce CO 2 Gas and effervescence, poor solubility of particles
At the same time, due to the presence of sodium glutamate and essence in this patent, the original taste cannot be achieved

Method used

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Embodiment Construction

[0020] This embodiment is made from the following raw materials and auxiliary materials in the following weight ratios: 417g donkey-hide gelatin, 525g sucrose, 19.6g sodium bicarbonate, 1.2g stevia, and 37.2g citric acid. Its production process is as follows:

[0021] 1. Preparation of adhesive: get 42g of sucrose and mix it with 70% syrup, then add twice the volume of 95% ethanol, mix well, and get final product.

[0022] 2. Grinding and sieving of raw and auxiliary materials: after pulverizing donkey-hide gelatin, sucrose and citric acid respectively, the sucrose is passed through a 80-mesh sieve, and the donkey-hide gelatin and citric acid are respectively passed through a 100-mesh sieve.

[0023] 3. Weighing: Weigh donkey-hide gelatin, the remaining sucrose, citric acid, stevia and sodium bicarbonate according to the prescription ratio.

[0024] 4. Granulation: Put donkey-hide gelatin, sucrose, citric acid, stevioside and sodium bicarbonate together in a fluidized bed one...

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Abstract

The invention discloses a donkey-hide glue effervescent granule and a method for preparing the same. The donkey-hide glue effervescent granule is characterized in that each 1,000g of donkey-hide glue effervescent granules are prepared from the following materials and auxiliary materials: 375 to 458g of donkey-hide glue, 472 to 578g of sugar, 15.0 to 25.0g of sodium bicarbonate, 1.0 and 5.0g of steviosin and 30.0 to 45.0g of citric acid. The method for preparing the donkey-hide glue effervescent granule comprises the following steps: 42g of the sugar is weighed up to prepare 70 percent syrup, the donkey-hide glue, the citric acid, the steviosin, the sodium bicarbonate and the residual sugar in recipe quantity are put in a fluidized bed one-step granulator for granulation, and the donkey-hide glue effervescent granule is obtained. In the invention, with the one-step granulating method, the working procedure is simplified, and all defects existing in prior preparing process are overcome; moreover, the donkey-hide glue effervescent granule and the method also have the advantages of simple operational procedures, good appearance of granules, good granule dissolvability, high rate of finished products, good taste of the granules and stable quality, and large granules or powder sifted out can be reutilized.

Description

(1) Technical field [0001] The invention relates to an effervescent granule and a preparation method thereof, belonging to the field of pharmaceutical preparations. (2) Background technology [0002] In the patent number: 90106302.9, the patent name is "Preparation Process of Ejiao Effervescent Granules", which adopts two-step granulation method, that is, acid granulation method and alkali granulation method. The process operation is very complicated and the labor productivity is low; Wet agent has poor adhesion, more fine powder, and lower yield of finished products; because acid granules and alkali granules are used to granulate separately, the final mixed granules have inconsistent colors, and the product appearance is poor, which is not easy for customers to accept ;Because the acid and base are in different particles, the acid and base cannot react quickly to produce CO 2 The gas is effervescent, and the solubility of the particles is poor. Simultaneously, because thi...

Claims

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Application Information

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IPC IPC(8): A61K35/36A61K9/16A61P7/06
Inventor 楚大祥张晓燕王英马继永丁海昕吴东华刘爱华高美霞
Owner SHANDONG HUAXIN PHARMA
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