Phosphorescence chemical sensor for qualitative homocysteine detection and use thereof

A photochemical sensor, homocysteine ​​technology, applied in the field of chemical sensors, can solve the problems of reporting iridium complexes
CN101430280AInactive Publication Date: 2009-05-13FUDAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
FUDAN UNIV
Publication Date
2009-05-13
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to the technical field of chemical sensor, in particular to a phosphorescent chemical sensor for qualitatively detecting homocysteine and an application thereof. Aldehyde group of iridium complex can take cyclization with amido and hydrosulphonyl in the homocysteine to be transformed into hexahydroxy heterocycle and transformed into another compound. The original iridium complex is conjugated with a benzene ring and the aldehyde group and represents as weak red fluorescence while the compound obtained after reaction is not conjugated with the aldehyde group and represents as strong green fluorescence. Ultraviolet and phosphorescent spectrum is used for detecting the result that the complex identifies the homocysteine, thereby showing that the complex has specific response towards the homocysteine, has high sensitivity and can be identified by naked eye, and furthermore, the complex can distinguish cysteine which has a structure very similar as the homocysteine.
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Description

technical field

[0001] The invention relates to the technical field of chemical sensors, in particular to a phosphorescent chemical sensor for qualitatively detecting homocysteine ​​and its application. Background technique

[0002] In recent years, the clinical application of homocysteine ​​is mainly used as a risk indicator for cardiovascular diseases, especially coronary atherosclerosis and myocardial infarction, and its concentration is directly proportional to the risk of the disease. In addition, according to the metabolic characteristics of homocysteine, vitamin B12, folic acid deficiency, and hereditary N5 methyltetrahydrofolate methyltransferase and cystathionine-β-synthase gene defects are also related to homocysteine ​​concentration. There is a close relationship, but the relationship between these factors and cardiovascular disease needs further study.

[0003] At present, the two main detection methods for homocysteine ​​are high performance liquid chromatograp...

Claims

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