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Stomach floater composition containing optimization treated starch for inducing satiation sense

A kind of composition and gastric floating technology, applied in the field of regulating the appetite of mammals, can solve the problems of short time period, etc., and achieve the effects of prolonging the delivery, improving the rate of glucose production, and prolonging the absorption

Inactive Publication Date: 2009-05-27
GLYCOLOGIC LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0022] However, despite the prolonged glucose release profile of many currently available starch products for the treatment of conditions such as GSD compared to glucose and maltodextrin based products, this product maintains serum glucose levels within an acceptable range relatively short period of time

Method used

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  • Stomach floater composition containing optimization treated starch for inducing satiation sense
  • Stomach floater composition containing optimization treated starch for inducing satiation sense
  • Stomach floater composition containing optimization treated starch for inducing satiation sense

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0130] The liquid form of alginic acid is prepared as follows:

[0131] Sodium alginate (Manugel LBA, International Specialty Products, Koln) sample (0.7g or 0.5g), 0.2g calcium carbonate (12467, Acros Organics, Geel) and 0.25g sodium bicarbonate (144-55-8, Aldrich, Gillingham) was dissolved in 10 ml of distilled water. Additionally, flavoring and / or coloring agents are added to some liquids.

[0132] These were poured into 20ml of 1M HCl contained in a 100ml beaker as described in Table 1. The prepared float has good function.

[0133] The mixture was also consumed by up to ten volunteer subjects, and satiety was described by those volunteer subjects. The feeling of fullness lasts for about six hours. Individuals did not crave snacks between meals, so calorie expenditure was significantly reduced.

Embodiment 2

[0135] The liquid form of low methyl pectin is prepared as follows:

[0136] Low methyl pectin (LM-104, CP Kelco, Lille / Svensked) sample (0.7g or 0.5g), 0.2g calcium carbonate (12467, Acros Organics, Geel) and 0.25g sodium bicarbonate (144-55- 8, Aldrich, Gillingham) was dissolved in 10 ml of distilled water. In addition to some liquids, flavoring and / or coloring agents are added.

[0137] These were poured into 20ml of 1M HCl contained in a 100ml beaker as described in Table 1. The prepared float has good function.

[0138] The mixture was also consumed by up to ten volunteer subjects, and satiety was described by those volunteer subjects. The feeling of fullness lasts for about six hours in most individuals. Individuals did not crave snacks between meals, so calorie expenditure was significantly reduced.

[0139] A mixture of alginate and pectin (as the polysaccharide fraction) was also tested and found to perform well.

Embodiment 3

[0141] Sodium alginate (Manugel LBA, International Specialty Products, Koln) sample (0.5g), 0.2g pregelatinized starch (NSG4, National Starch and Chemical, Manchester), 0.2g calcium carbonate (12467, Acros Organics, Geel) and 0.25 g of sodium bicarbonate (144-55-8, Aldrich, Gillingham) was dissolved in 10 ml of distilled water. In addition to some liquids, flavoring and / or coloring agents are added.

[0142] These were poured into 20ml of 1M HCl contained in a 100ml beaker as described in Table 1. The prepared float has good function.

[0143] The mixture was also consumed by up to ten volunteer subjects, and satiety was described by those volunteer subjects. The feeling of fullness lasts for about six hours. Individuals did not crave snacks between meals, so calorie expenditure was significantly reduced. The cost of the product is cheaper than pure alginate or pectin (as polysaccharide) considering dilution by starch.

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Abstract

Provided are methods of inducing satiety in an individual using gastric raft compositions and compositions suitable for such methods. The gastric raft compositions may comprise processed starches such as dextrins. Also described are methods of treating diseases characterised by hypoglycaemia, such as glycogen storage disease (GSD), and diabetes.

Description

field of invention [0001] The present invention relates to methods of regulating appetite in mammals. In particular, it relates to methods of inducing satiety in an individual and compositions suitable for such use. It also provides methods of prolonging the retention of a dietary energy source in the stomach and methods of treating diseases characterized by hypoglycemia such as glycogen storage diseases (GSD) and diseases such as diabetes. Background of the invention [0002] Obesity is a growing global health problem and has become a major cause and / or risk factor for many health problems such as cardiovascular disease (such as hypertension and arteriosclerosis), non-insulin-dependent diabetes mellitus, bone and joint inflammation and some cancers. To help individuals lose weight, a number of dietary aids and treatments have been proposed, including pharmaceutical, dietary or surgical interventions. [0003] One approach that has been used is the use of foods that induc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K47/36A61P3/04A61P3/06A61P3/08
CPCA61K9/0065A61P1/00A61P1/04A61P1/16A61P3/00A61P3/04A61P3/06A61P3/08A61P3/10
Inventor 理查德·特斯特丹妮丝·霍珀
Owner GLYCOLOGIC LTD