Granular formulation with heat-clearing and detoxicating, promotion of diuresis and tonglin function and preparation method and detection method

Abstract

The present invention discloses a granular formulation with heat-clearing and detoxicating, promotion of diuresis and tonglin function and preparation method and detection method. The granular formulation is made by Polygonum capitatum. (four seasons red) 2700 units, plantain 1300 units, dextrin 810 units and 30 Sodium cyclamate units in weight unit. Compared with current technology, the Sodium cyclamate is used as flavoring agent replacing steviosion in the invention, which overcomes problem of poor taste when taking steviosion as flavoring agent and difficulty in taking medicine to patients; dextrin dosage is increased so as to overcome problem of low yield of dry paste in actual production and insufficiency of extract quantity; thick paste density adjusted after liquid medicine concentrated, and can complete concentration process directly in decompression concentrator. No need of adding a great amount of water in pellet fabrication process which avoids waste of energy sources, equipment and human energy, reduces production cost, meanwhile guaranties product quality; and gallic acid shallow layer identification item is reestablished in quality detecing. The method is of good specificity, strong particularity and high sensitivity, has no interference to negative control, and can ensure product quality and curative effect.

Description

Technical field: [0001] The invention relates to a granule for clearing away heat, detoxification, diuresis and treating stranguria, a preparation method and a detection method thereof, and belongs to the technical field of traditional Chinese medicine pharmacy. Background technique: [0002] Tonglinshu granule, which is recorded in the national standard part of the local standard of Chinese patent medicine in the national standard compilation of Chinese patent medicine (internal medicine kidney system sub-volume), is composed of Sijihong and plantain; it has the effect of clearing away heat and detoxification, diuresis and Tonglin; It is used for stranguria syndrome caused by accumulation of damp-heat, which shows poor urination, dripping and astringent pain. However, in the original trial standard of Tonglinshu Granules, stevioside is used as the flavoring agent, and stevioside is characterized by being sweet first and then bitter. Obstacles; and in the actual production,...

AI Technical Summary

Problems solved by technology

However, in the original trial standard of Tonglinshu Granules, stevioside was used as the flavoring agent, and the characteristic of stevioside is that it is sweet at first and then bitter. Obstacles; and in the actual production, the yield of the dry paste obtained by extraction and concentration is low, and the amount of extract is insufficient, so the amount of dextrin must be increased to prepare the specified amount of particles; the clear paste after the concentration of the extract is too thin, and the amount of ethanol added It is very large, causing difficulties in production operation and waste of manpower and equipment, and the production cost is relatively high; in large-scale production, due to equipment reasons, the extract after ethanol precipitation cannot be concentrated to a relative density of 1.35 to 1.40 ( 60°C) must be released from the pipeline and then concentrated in a jacketed pot, thus increasing the production process and increasing the probability of the extract being polluted; at the same time, due to the relative density of the thick paste being too thick, A large amount of water is also added in the granulation process, resulting in a great waste of energy, equipment and manpower

In addition, in the original quality standard of Tonglinshu Granules, there is a difference between the property item and the property of the product obtained in actual production; in the identification item, it is difficult to judge the spots on the chromatogram of the test product and the chromatogram of the reference medicinal material during actual testing. affect the accuracy of test results

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