The invention discloses a de-alcoholic fish stuffed bun and a making method thereof. The de-alcoholic fish stuffed bun is mainly made of materials according to parts by weight by mixing, and the materials include flour, mandarin fish, streaky pork, pigskin jelly, agaric, shiitake, celery, chopped green onion, bruised ginger, white sugar, yellow rice wine, sweet potato starch, sesame oil, spiced vinegar, soy sauce, refined salt, pepper powder and monosodium glutamate. A stuffing formula for the de-alcoholic fish stuffed bun is unique, the mandarin fish tastes tender and delicious, the stuffing with the mandarin fish tastes unique, protein, fat, vitamins and cellulose are reasonably allocated, and accordingly the de-alcoholic fish stuffed bun is nutrient, and is a good health food suitable for young and old. Adding silybum marianum, plantain, green tea and lotus leaf juice in bun making and dough mixing makes the de-alcoholic fish stuffed bun health-care, de-alcoholic and liver-protective.