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Difructose anhydride-containing composition and use thereof

A kind of double fructose anhydride, containing technology, applied in the field of DFA-containing composition, can solve the problem of not clearly pointed out or mentioned, producing organic acid and the like

Inactive Publication Date: 2009-07-01
FUAN KERU +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it has not yet been clarified whether it will interact with cavity-inducing bacteria in the oral cavity to produce organic acids
Moreover, as far as the effect of suppressing tooth decay induction is concerned, none of the previous technologies clearly pointed out or mentioned

Method used

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  • Difructose anhydride-containing composition and use thereof
  • Difructose anhydride-containing composition and use thereof
  • Difructose anhydride-containing composition and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0099] The present invention uses the Ussing chamber to confirm whether DFAIII can promote the absorption of magnesium as follows.

[0100] The test objects used in this test are Sprague-Dawley male mice (average weight about 260 g) aged about 7-8 weeks. The mice were about 6 weeks old when purchased (Japan SLC Co., Ltd.), and were fed with commercially available solid feed (CE-2, Japan CLEA Co., Ltd.) until the day before the experiment.

[0101] On the day of the experiment, sleeping pills were fed into the abdominal cavity of the mice, and the small intestines (jejunum and ileum) and large intestines (cecum and colon) were taken out under anesthesia. After spreading out the sundries in their intestines, peel off the serosa and smooth tendon layer, and make a specimen Ussing chamber composed of mucosa and mucosal tissue (the actual effective area is 0.67Cm 2 ).

[0102] On the other hand, the mucosal buffer and serosal buffer are prepared respectively. The basic compositi...

Embodiment 2

[0123] MgCl in lateral membrane buffer 2 ·6H 2 O 1mM replaced by ZnSO 4 ·7H 2 O 0.0125mM, when measuring the absorption rate of zinc, the concentration of ions is set to 0.0125mM, and the serous membrane buffer is the same, except that ZnSO is used instead 4 ·7H 2 Except 0 1mM, all the other are the same as embodiment 1 to measure the speed of zinc absorption.

[0124] The results obtained are shown in Figure 2. It can be clearly shown that as the concentration of DFAIII increases, the absorption of zinc also increases.

Embodiment 3

[0126] MgCl in lateral membrane buffer 2 ·6H 2 O 1mM was replaced by CuCl 2 2H 2 O 0.0125mM, when measuring the absorption rate of copper, the concentration of ions is set to 0.0125mM, and the serous membrane buffer is the same, except that CuCl is used instead 2 2H 2 Except 0 1mM, all the other are the same as embodiment 1 to measure the speed of copper absorption.

[0127] The results obtained are shown in Figure 3. It can be clearly shown that as the concentration of DFAIII increases, the uptake of copper also increases.

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Abstract

The present invention relates to a difructose anhydride (DFA)-containing composition and use thereof DFA is a cyclic disaccharide in which the reducing termini of two fructose molecules bind each other to hydroxyl groups at the other nonreducing termini. According to the present invention, it has been revealed that DFA is effective in accelerating the absorption of magnesium, zinc or copper, accelerating bone formation, accelerating diuretic action, and improving bowel movement and is useful in inhibiting dental caries. A composition of the present invention can be used as a composition for a medicinal product and a food or drink product (including feed for animal use). Examples of a medicinal product and a food or drink product for human or animal use include formulated powder milk, parenteral nutrients, health food and drink products, and additives for feed and are not particularly limited as long as they are ultimately in an orally administrable form.

Description

technical field [0001] The present invention relates to a composition containing double fructose anhydride (DFA) and its application. In detail, it relates to a composition containing DFA, which has related uses such as promoting the absorption of magnesium, zinc and copper, promoting bone formation, facilitating urination, improving constipation and inhibiting tooth decay. Background technique [0002] Although the dietary life has been greatly improved, especially the Japanese intake of magnesium, zinc and copper is lower than the minimum nutritional requirements (Journal of Nutritional Science and Vitaminalogy 45 volumes 519-532 pages), it is necessary to actively Improve this deficiency. However, as far as the current situation is concerned, it is actually difficult for Japanese people to sufficiently absorb these inorganic components in their dietary life. [0003] In recent years, the indigestible disaccharide difructoan III (hereinafter also referred to as DFA III) ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7016C07H3/04A61P1/00A61P1/02A61P1/14A61P3/00A61P7/10A61P19/00A61P1/16A61P3/12A61P3/14A61P9/00A61P11/00A61P13/12
Inventor 重松典宏塩见卓也奥原康英田村亚纪子富田响子菊地裕人有塚勉富田房男
Owner FUAN KERU