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Cotinus coggygria compound preparation and use

A technology of compound preparation and cotinus sumac, applied in anti-inflammatory agents, anti-toxic agents, pharmaceutical formulas, etc., can solve the problems of high dosage, reduce dosage, improve therapeutic effect, and improve the body's resistance to hypoxia

Inactive Publication Date: 2012-08-22
龙丽辉 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the single effective component of Cotinus cotinus is too large to be taken as a medicine

Method used

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  • Cotinus coggygria compound preparation and use
  • Cotinus coggygria compound preparation and use
  • Cotinus coggygria compound preparation and use

Examples

Experimental program
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Effect test

Embodiment 2

[0039] 1 method

[0040] Hypoxia Tolerance Test in Mice [11] : 80 ICR mice were taken, half male and half male, randomly divided into 8 groups according to body weight, 10 mice in each group. Respectively: (1), normal group (gastric administration of distilled water); (2), propranolol group: (0.0135g / kg); (3), large, medium and small dose groups of compound sumac (20.0g / kg , 10.0g / kg, 5.0g / kg). Gavage administration, gavage volume 10mL / kg, 1h later, put the mice into 125mL jars with stoppers containing 7.5g sodium carbonate, apply Vaseline to the mouth of the bottle, seal, time, observe and record the mice time to death from hypoxia asphyxiation. Swap the bottles clockwise after a round is done.

[0041] 2 Results and conclusion

[0042] See Table 1 for the effect of Cotinus cotinus compound recipe on hypoxia tolerance in mice. As can be seen in Table 1, compared with the negative control group, the cotinus cotinus compound large dose group and the middle dose group have...

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PUM

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Abstract

The invention relates to a cotinus coggygria scop compound preparation, which is prepared from cotinus coggygria scop, rhizoma corydalis and hawkthorn in proportion, wherein the dosage of the cotinus coggygria scop is equal to that of the hawkthorn, and the dosage of the rhizoma corydalis is not more than 2 / 3 of that of the cotinus coggygria scop or the hawkthorn. The cotinus coggygria scop compound preparation can be used as an anticoagulant and antithrombotic drug, an abirritation drug, a drug for activating blood circulation to dissipate blood stasis and reducing the whole blood viscosity,a drug for improving the organism anti-hypoxia effect, and a drug for treating coronary heart disease or coronarism or miocardial infarction. The cotinus coggygria scop compound preparation not only improves the curative effect of the cotinus coggygria scop, but also reduces the dosage, and is used for easing pain and treating cardiovascular and cerebrovascular disease. Comparative experiments prove that the compound preparation has equivalent anticoagulant activity and abirritation as aspirin, and has the function of organism hypoxia resistance.

Description

technical field [0001] The invention relates to the technical field of medicines for human use, in particular to the use and preparation of plant sumac compound. Background technique [0002] Cotinus coggygra Scop. is a plant of the genus Cotinus coggygra in the Anacardaceae family, a deciduous shrub or small tree, up to 8m in height, and its leaves turn red after frost in autumn, commonly known as Fragrant Hills red leaves. Although this plant has not yet entered the Chinese Pharmacopoeia as a medicinal material, many pharmacodynamic tests in recent years have shown that it has antibacterial effects, significant anti-hepatitis activity, and obvious anti-fatigue effects. Research. In Chinese patent application 200610042000.3, the inventor studied the efficacy of Cotinus cotinus in anticoagulant, antithrombotic, hypotensive effects and therapeutic drugs. [0003] However, the dosage of the single effective component of Cotinus cotinus as a medicine is too large. Contents ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/734A61K31/4745A61P7/02A61P29/00A61P9/10A61P39/00A61P7/00
Inventor 崔恩贤龙丽辉张公奇李欣常永孝李天生张洁群
Owner 龙丽辉
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