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Method for preparing nitric oxide releasing tablet

A nitric oxide and tablet technology, which is applied in the field of preparation of nitric oxide release tablets, can solve the problems of incapability of industrialized treatment, difficulty in fresh-keeping industry application, inconvenient storage and use, etc., and achieves no residual toxicity, simple operation, The effect of high utilization value

Inactive Publication Date: 2009-08-12
SHANDONG AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is extremely inconvenient to preserve and use and cannot be processed industrially
In this way, although NO treatment has a remarkable fresh-keeping effect on fruit, it is difficult to apply it in the fresh-keeping industry.

Method used

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  • Method for preparing nitric oxide releasing tablet
  • Method for preparing nitric oxide releasing tablet
  • Method for preparing nitric oxide releasing tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] (1) Synthesis of adduct of divinyltriamine and nitric oxide

[0024] Dissolve 5.00 g of divinyltriamine in 150 mL of anhydrous acetonitrile, bubbling with nitrogen for 15 min to remove oxygen, and bubbling with NO gas for 24 h. After the reaction is complete, nitrogen is passed to remove the remaining NO gas, and the reaction mixture is suction filtered and dried under vacuum to obtain 7.14 g of adduct of divinyltriamine and nitric oxide.

[0025] (2) Preparation of divinyltriamine and nitric oxide adduct release tablets

[0026] Dry the wheat starch, weigh 100 mg of divinyl triamine and nitric oxide adduct, 500 mg of citric acid, and 1000 mg of wheat starch in a mortar, grind and mix them, and press them into 10 tablets.

[0027] See attached image 3 , Using ISO-NOPF200 electrode combined with Apollo 1000 free radical analyzer (WPI, USA) to monitor the change of NO released by a divinyltriamine and nitric oxide adduct release tablet in a 1L container with time, the result...

Embodiment 2

[0029] (1) Synthesis of the adduct of spermine and nitric oxide

[0030] Dissolve 5.00 g spermine in 150 mL anhydrous acetonitrile, bubbling nitrogen for 15 min to remove oxygen, and bubbling NO gas for 20 h. After the reaction is complete, nitrogen is passed to remove the remaining NO gas, and the reaction mixture is suction filtered and dried in vacuum to obtain 6.39 g of spermine and nitric oxide adduct.

[0031] (2) Preparation of adduct release tablets of spermine and nitric oxide

[0032] Dry the wheat starch, weigh 100 mg of spermine and nitric oxide adduct, 420 mg of citric acid, and 1000 mg of wheat starch in a mortar, grind and mix them, and press them into 10 tablets.

[0033] See attached Figure 4 , Put 1 tablet of spermine and nitric oxide adduct release tablet into a 4L container, use ISO-NOPF200 electrode combined with Apollo 1000 free radical analyzer (WPI company, USA) to monitor NO in the container when kiwifruit is placed and not Concentration, the results show ...

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PUM

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Abstract

The present invention relates to a method for preparing a nitric oxide releasing tablet. The nitric oxide releasing tablet is prepared through uniformly mixing the synthesized adduct comprising polyamine and nitric oxide, solid acid and furnace-dried water absorber, comminuting and tabletting. The tablet can automatically release nitric oxide in damp environment and has the advantages of simple processing technique and suitability for industrial mass production. The tablet of the invention is suitable for storing and executing fresh-keeping to the fruits of yangtao, Feicheng peach, apple, strawberry, plum, etc., and the gardening products of vegetable, cut flower, etc., and the agricultural product.

Description

(1) Technical field [0001] The invention relates to a preparation method of a nitric oxide releasing tablet, which can be applied to the storage and preservation of fruits such as kiwi, Feicheng peach, apple, strawberry, plum and other horticultural products and agricultural products such as vegetables and fresh cut flowers. (2) Background technology [0002] In 1996, Leshem and Haramaty reported for the first time the production and role of endogenous nitric oxide (NO) in cash crops, and proposed that NO is used as a regulator of fruit ripening. After that, further studies have found that the amount of endogenous NO produced by the fruit gradually decreases, and ethylene The level is gradually increasing, NO is related to ethylene biosynthesis of garden products, and NO can inhibit fruit ripening and senescence. In 2001, Leshem et al. proposed the specific mode of action of NO in the regulation of ethylene: NO inhibits the activities of the two rate-limiting enzymes ACC oxidase ...

Claims

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Application Information

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IPC IPC(8): A23B7/153A23B7/154A23B7/157A01N3/02
Inventor 周杰张丽丽陈长宝朱树华朱丽琴
Owner SHANDONG AGRICULTURAL UNIVERSITY
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