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Methods and compositions for the treatment and prevention of infections

A subject, cyclic compound technology, applied in the direction of botany equipment and methods, drug combination, sensory disease, etc., can solve the problems of stability and effectiveness, unused potential of antibacterial agents, underutilized sodium perborate, etc.

Inactive Publication Date: 2009-08-26
ADVANCED VISION RESEARCH INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to these limitations, chlorine dioxide has not yet reached its full potential as an antimicrobial
Likewise, other oxidative antimicrobials such as sodium perborate are underutilized due to stability and effectiveness issues

Method used

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  • Methods and compositions for the treatment and prevention of infections
  • Methods and compositions for the treatment and prevention of infections
  • Methods and compositions for the treatment and prevention of infections

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0072] A study was conducted to evaluate the stability of three different eye care formulations containing chlorine dioxide. Base formulations were prepared with 0.005% chlorine dioxide alone, or with 0.005% chlorine dioxide and 2.5% dyphylline. This study incorporates the evaluation of each formulation with and without autoclave sterilization during manufacture.

[0073] The analysis was conducted under three storage conditions: 5°C, 25°C / 60% Relative Humidity (RH) and 40°C / 75%RH, tested and analyzed by the USP Antimicrobial Effectiveness (Preservative Efficacy) over a three-month time frame Test both compositions. Analytical tests for chlorine dioxide content, pH and osmolality were performed every two weeks for three months. Antimicrobial effectiveness of formulations was evaluated on a monthly basis based on acceptance criteria for Class 1 articles in initial antimicrobial effectiveness testing.

[0074] Analytical testing of the dyphylline / chlorine dioxide samples show...

Embodiment 5

[0077] During the conduct of the initial study, a confirmatory study was performed to confirm the results of the antimicrobial effectiveness of the autoclaved dyphylline / chlorine dioxide samples. In addition to this sample, an autoclaved chlorine dioxide formulation and formulation was prepared based on Example 5 of US Patent 6,024,954 (consistent with Refresh). Using the USP antimicrobial effectiveness test, all three formulations containing dyphylline / chlorine dioxide and the formulation based on Example 5 of US Patent 6,024,954 (consistent with Refresh), and the formulation containing chlorine dioxide alone were tested after 28 days. The sample failed again on day 7.

[0078] introduce

[0079] For stability evaluation, formulations were prepared with the following variations:

[0080] Table 1: Chlorine Dioxide Formulations

[0081] Chemicals

percentage

CMC

0.25％

Sodium chloride

0.22218％

potassium chloride

0.07315％

...

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PUM

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Abstract

The present invention provides preparations comprising an oxidizing antimicrobial agent such as chlorine dioxide and a heterocyclic compound that improves the antibacterial effect of the oxidizing antimicrobial agent preparation. The invention has particular use as an eye care preparation such as an eye drop. The invention further provides methods for reducing bacterial colonization and treating infection.

Description

Background of the invention [0001] The condition known as dry eye causes chronic eye irritation caused by decreased tear production or increased evaporation, resulting in loss of moisture from the tear film and an increase in tear film osmolality. This increase in tear film osmolality leads to osmotic dehydration of the surface associated with a decrease in goblet cell density of the conjunctiva. Recently, it has been shown that the eyelids of dry eye subjects have increased bacterial colonization, and bacteria found in these subjects reduced the proliferation of conjunctival goblet cells in tissue culture (Graham et al. The flora analysis of Ocular Surface, 3 (1): S68, 2005). It is also known that dry eye patients are prone to ocular infections, especially when wearing contact lenses (Lemp MA "Contact lens wearers have risk of dry eye?", Cornea (USA), 1990, 9 Suppl pp. 148-50; Discussion p. 54). [0002] Punctal plugs are commonly used to treat dry eye. They relieve sympto...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00
CPCA61K9/0048A61K33/20A61K33/40A01N59/00A61K31/522A61K45/06A61P27/02A61P31/04A61P43/00Y02A50/30A61K33/02
Inventor J·P·吉尔巴德
Owner ADVANCED VISION RESEARCH INC
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