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Application of tea polyphenol in preparing medicament for treating tumor

A technology of tea polyphenols and medicaments, applied in the application field of tea polyphenols in the treatment of tumors, can solve the problems of low tumor proliferation activity and expensive pure products, and achieve obvious economic benefits, obvious therapeutic effects, and toxic reactions. low effect

Inactive Publication Date: 2009-09-09
张莉 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Foreign studies on EGCG's inhibition of tumor proliferation are mainly in vitro experiments. The cell lines studied include solid tumor cells such as prostate cancer, gastric cancer, colon cancer, skin cancer, breast cancer, lung cancer, and leiomyosarcoma, but its activity of inhibiting tumor proliferation is not significant. Very strong, and the pure products of EGCG and EGC are quite expensive, and there is no further in vivo research report

Method used

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  • Application of tea polyphenol in preparing medicament for treating tumor
  • Application of tea polyphenol in preparing medicament for treating tumor
  • Application of tea polyphenol in preparing medicament for treating tumor

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Embodiment

[0041] A drug for treating tumors made from tea polyphenols extracted from green tea, which is a green tea capsule produced by Pharmanex in the United States The capsules contain tea polyphenol powder, with a total weight of 250mg per capsule, including 162mg of catechins (including 95mg of EGCG, 37mg of ECG, and 15mg of EGC, with molecular weights of 458.4, 442.4, and 306.3), and less than 0.5mg of caffeine. (For more detailed ingredients, please refer to the American physician's desk manual: Physicians'desk Ingredients of Pharmanex, 2005, 59Edition: 2782.)

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Abstract

The invention provides application of tea polyphenol in preparing a medicament for treating tumor. The invention uses a tea extract, namely the tea polyphenol to directly prepare an antitumor medicament, and does not need to separate pure products of effective components such as EGCG, EGC, and ECG from the tea polyphenol through complicated and expensive purification process, thereby greatly reducing production cost for the medicament. A pharmacological experiment of cellular level finds that the tea polyphenol has obvious inhibition effect on various human tumor cells. A therapeutic effect experiment of a mouse tumor model finds that the medicament has obvious therapeutic effect on mouse tumor.

Description

technical field [0001] The invention relates to a tea polyphenol preparation, in particular to the application of tea polyphenols in treating tumors. technical background [0002] The current methods of drug treatment of tumors mainly include cytotoxicity, induction of apoptosis and differentiation, and biological targeted therapy. [0003] Some ingredients, derived from natural plants and minerals, play a pivotal role in the first two methods. Such as vincristine, homoharringtonine, hydroxycamptothecin, paclitaxel and arsenous acid. However, to varying degrees, inhibition of normal cell proliferation and growth, peripheral neurotoxicity, impairment of important organ functions and other toxic and side effects are important factors that limit the application of these drugs. And its pharmacoeconomics is an important factor that has to be considered. [0004] Biological targeted therapy applies "tailor-made" drugs aimed at the pathogenesis of tumors, including imatinib mesy...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P35/00
CPCA61K31/353A61P35/00A61P35/02
Inventor 张莉刘蕴华
Owner 张莉
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