Application of tea polyphenol in preparing medicament for treating tumor
A technology of tea polyphenols and medicaments, applied in the application field of tea polyphenols in the treatment of tumors, can solve the problems of low tumor proliferation activity and expensive pure products, and achieve obvious economic benefits, obvious therapeutic effects, and toxic reactions. low effect
Inactive Publication Date: 2009-09-09
张莉 +1
View PDF0 Cites 3 Cited by
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Foreign studies on EGCG's inhibition of tumor proliferation are mainly in vitro experiments. The cell lines studied include solid tumor cells such as prostate cancer, gastric cancer, colon cancer, skin cancer, breast cancer, lung cancer, and leiomyosarcoma, but its activity of inhibiting tumor proliferation is not significant. Very strong, and the pure products of EGCG and EGC are quite expensive, and there is no further in vivo research report
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View moreImage
Smart Image Click on the blue labels to locate them in the text.
Smart ImageViewing Examples
Examples
Experimental program
Comparison scheme
Effect test
Embodiment
[0041] A drug for treating tumors made from tea polyphenols extracted from green tea, which is a green tea capsule produced by Pharmanex in the United States The capsules contain tea polyphenol powder, with a total weight of 250mg per capsule, including 162mg of catechins (including 95mg of EGCG, 37mg of ECG, and 15mg of EGC, with molecular weights of 458.4, 442.4, and 306.3), and less than 0.5mg of caffeine. (For more detailed ingredients, please refer to the American physician's desk manual: Physicians'desk Ingredients of Pharmanex, 2005, 59Edition: 2782.)
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More PUM
Login to View More Abstract
The invention provides application of tea polyphenol in preparing a medicament for treating tumor. The invention uses a tea extract, namely the tea polyphenol to directly prepare an antitumor medicament, and does not need to separate pure products of effective components such as EGCG, EGC, and ECG from the tea polyphenol through complicated and expensive purification process, thereby greatly reducing production cost for the medicament. A pharmacological experiment of cellular level finds that the tea polyphenol has obvious inhibition effect on various human tumor cells. A therapeutic effect experiment of a mouse tumor model finds that the medicament has obvious therapeutic effect on mouse tumor.
Description
technical field [0001] The invention relates to a tea polyphenol preparation, in particular to the application of tea polyphenols in treating tumors. technical background [0002] The current methods of drug treatment of tumors mainly include cytotoxicity, induction of apoptosis and differentiation, and biological targeted therapy. [0003] Some ingredients, derived from natural plants and minerals, play a pivotal role in the first two methods. Such as vincristine, homoharringtonine, hydroxycamptothecin, paclitaxel and arsenous acid. However, to varying degrees, inhibition of normal cell proliferation and growth, peripheral neurotoxicity, impairment of important organ functions and other toxic and side effects are important factors that limit the application of these drugs. And its pharmacoeconomics is an important factor that has to be considered. [0004] Biological targeted therapy applies "tailor-made" drugs aimed at the pathogenesis of tumors, including imatinib mesy...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More Application Information
Patent Timeline
Login to View More Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P35/00
CPCA61K31/353A61P35/00A61P35/02
Inventor 张莉刘蕴华
Owner 张莉