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Method for controlling quality of Chinese medicinal preparation for treating chronic prostatitis

A quality control method and technology for chronic prostatitis, applied in drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve problems such as unscientific quality control and uneven quality

Active Publication Date: 2009-09-23
BEIJING ASIA EAST BIO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to unscientific quality control, its quality is uneven, so it is necessary and feasible to invent a traditional Chinese medicine preparation with definite curative effect, stable quality and reliable curative effect

Method used

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  • Method for controlling quality of Chinese medicinal preparation for treating chronic prostatitis
  • Method for controlling quality of Chinese medicinal preparation for treating chronic prostatitis
  • Method for controlling quality of Chinese medicinal preparation for treating chronic prostatitis

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0092] Experimental example 1: Identification test screening - identification of Mian

[0093] (A) preparation method of need testing solution

[0094] (1) Take 5g of this product, add 20ml of ethanol, reflux on a water bath for 40 minutes, take 10ml of the supernatant, add 1ml of hydrochloric acid, heat and reflux for 1 hour, concentrate to about 5ml, add 10ml of water, shake and extract with 20ml of cyclohexane , The extract was evaporated to dryness, and the residue was dissolved by adding 2ml of chloroform as the test solution.

[0095] (2) Take 5g of this product, add 20ml of ethanol, reflux on a water bath for 40 minutes, take 10ml of the supernatant, add 1ml of hydrochloric acid, heat and reflux for 1 hour, concentrate to about 5ml, shake and extract with 20ml of ether, and evaporate the extract to dryness , Add 2ml of chloroform to the residue to dissolve it as the test solution.

[0096] (3) Take 5g of this product, add 50ml of methanol, heat to reflux for 1 hour, f...

experiment example 2

[0107] Experimental example 2: identification test screening - identification of Cortex Phellodendri

[0108] The preparation method of need testing solution

[0109] (1) Take 2g of this product, add methanol 20ml, sonicate for 15 minutes, filter, and concentrate the filtrate to 2ml as the test solution.

[0110] (2) Take 2g of this product, add 20ml of methanol, reflux in a water bath for 15 minutes, filter, and concentrate the filtrate to 2ml as the test solution.

[0111] (B) Selection of developer

[0112] (1) Ethyl acetate - butanone - formic acid - water (10:6:1:1)

[0113] (2) Butanol-glacial acetic acid-water (7:1:2)

[0114] Take another 0.1 g of Cortex Phellodendri as reference medicinal material, and prepare the reference medicinal material solution in the same way.

[0115] Then take the berberine hydrochloride reference substance, add methanol to make a solution containing 0.5mg per 1ml, as the reference substance solution.

[0116] According to the test of t...

experiment example 3

[0121] Experimental Example 3: Identification Test Screening - Identification of Panax notoginseng

[0122] (A) preparation method of need testing solution

[0123] (1) Take 2g of this product, add 20ml of methanol, sonicate for 30 minutes, let it stand still, take 10ml of supernatant, evaporate to dryness, add 25ml of water to the residue to dissolve, add 5ml of 10% sodium hydroxide solution, shake well, and saturate with water Shake butanol to extract twice, 30ml each time, combine the n-butanol solution, add water to wash twice, each time 40ml, discard the water solution, evaporate the n-butanol solution to dryness, add 3ml water to the residue to dissolve, and pass through the D101 macropore Adsorption resin column, 40-60 mesh, wet-packed column, inner diameter 1cm, length 25cm, in a small glass column, wait for the resin to settle, cover with a little absorbent cotton, add a little cotton and lightly press, rinse with water and immerse in water for later use. First elute...

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Abstract

The invention discloses a method for controlling the quality of a Chinese medicinal preparation treating chronic prostatitis. The method is characterized in that the qualitative identification on thin layers of dioscorea spongiosa, yellow-corktree bark and radix notoginseng is included, and the quantitative measurement on the content of lysimachia is also included, so the safety and effectiveness of the medicine are ensured, the product quality is improved and the standardized production of the medicine is facilitated.

Description

technical field [0001] The invention relates to a quality control method of a traditional Chinese medicine composition, in particular to a quality control method of a traditional Chinese medicine composition for treating chronic prostatitis. Background technique [0002] Prostate disease is a common disease in the male genitourinary system, mainly including prostatitis, benign prostatic hyperplasia and prostate cancer. Most men will suffer from prostate diseases to varying degrees throughout their lives, especially chronic prostatitis. It has been found in men aged 20-65, and the incidence rate is high in men aged 22-40, and the incidence trend is younger. [0003] Antibiotic treatment is a commonly used method in the clinical treatment of prostatitis. In theory, antibiotics are only effective for acute bacterial prostatitis and chronic bacterial prostatitis. It is not effective for non-bacterial prostatitis, and the abuse of antibiotics can easily lead to bacterial drug ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8945A61K9/16A61P13/08G01N30/90G01N30/36
Inventor 付立家付建家
Owner BEIJING ASIA EAST BIO PHARMA CO LTD
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