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Ginseng stem leaf total sapogenin oral pharmaceutical preparation as well as preparation method and application thereof

A technology of ginseng stems and leaves and total saponins, which is applied in the direction of drug combination, pharmaceutical formula, and pill delivery, and can solve the problems of ignoring the research, effect and application status of total saponins in ginseng stems and leaves.

Inactive Publication Date: 2009-09-30
北京凯瑞创新医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the existing technologies have neglected the research on the total saponins in stems and leaves of ginseng, and its effects and applications have been in a blank state.

Method used

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  • Ginseng stem leaf total sapogenin oral pharmaceutical preparation as well as preparation method and application thereof
  • Ginseng stem leaf total sapogenin oral pharmaceutical preparation as well as preparation method and application thereof
  • Ginseng stem leaf total sapogenin oral pharmaceutical preparation as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0136] Take 100g of ginseng stem and leaf total saponins, add chitosan 20g, polyvinylpyrrolidone 20g, carbomer 10g, poloxamer 50g, lecithin 50g, micropowder silica gel 50g, beta cyclodextrin 100g, starch 100g, vibrate Grinding and superfine pulverization and mixing for 30 minutes, subpackaging to make powder.

Embodiment 2

[0138] Take 70g of ginseng stem and leaf total saponins and 10g of kudzu root flavonoid aglycones, add chitosan 5g, carbomer 5g, poloxamer 14g, lecithin 10g, micronized silica gel 10g, beta cyclodextrin 20g, carboxymethyl Starch sodium 6g, microcrystalline cellulose 50g, heavy-pressure grinding supermicrocomputer ultrafine pulverization for 30 minutes, adding 70% ethanol to combine for 10 minutes, making pellets, grading and rounding, drying, polishing, sub-packaging, and making Form into pills.

Embodiment 3

[0140] Take 80g of ginseng stem and leaf total saponins, 40g of ginseng stem and leaf polysaccharides, add chitosan 2g, lecithin 10g, add dextrin 66g, aspartame 2g, stir evenly, dry press granules, pack separately, and make granules agent.

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PUM

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Abstract

The invention relates to a ginseng stem leaf total sapogenin oral pharmaceutical preparation as well as a preparation method and an application thereof, belonging to the field of traditional Chinese medicines. Total aglycone extracted from ginseng stem leaf is hydrolyzed to obtain ginseng stem leaf total sapogenin, and the ginseng stem leaf total sapogenin is made into an efficient preparation by matching with a special auxiliary material, thereby the bioavailability of the ginseng stem leaf total sapogenin can be greatly improved. The preparation has obvious curative effect in the aspect of curing diseases such as coronary heart disease, stenocardia, miocardial infarction, hepatitis, tumour, pulmonary heart disease, high blood pressure, and the like or the aspect of preventing depressive illness and senile-resistant.

Description

technical field [0001] The invention relates to a traditional Chinese medicine ginseng stem and leaf extract, in particular to an extract of ginseng stem and leaf total saponins, and the medicinal use of the extract. It belongs to the field of traditional Chinese medicine. Background technique [0002] Ginseng is the dried root of Araliaceae plant ginseng (Panaxginseng C.A.Mey.). The use of ginseng by humans has been recorded in "Shen Nong Mu Cao Jing", which has a history of more than 2,000 years, but people tend to use ginseng roots. However, the development of ginseng stems and leaves has only begun in recent years. Ginseng stems and leaves are the aerial parts of ginseng, which have a higher content of total ginseng saponins than roots, and have the functions of nourishing qi and benefiting lungs, dispelling heat, and promoting body fluid. Unclear, tired limbs embolism. [0003] There are many reports about ginseng stems and leaves. Yu Chunhao et al. in "Research on E...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61K9/20A61K9/48A61K9/16A61K47/38A61K47/36A61K47/32A61K47/40A61K47/34A61K47/24A61K47/10A61P9/10A61P1/16A61P35/00A61P9/12A61P25/24A61K135/00A61K127/00
Inventor 李钦青贾世伟
Owner 北京凯瑞创新医药科技有限公司
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