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Polycaprolactone (PCL) static spinning nerve conduit and preparation and application thereof

A technology of nerve conduit and electrospinning, which is applied in the field of nerve conduit and its preparation and application, can solve problems such as time-consuming, nerve stimulation function damage, and unsatisfactory nerve recovery effect, so as to promote regeneration and repair, and is easy to operate , low cost effect

Inactive Publication Date: 2009-09-30
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above three treatment options have not completely solved the problem. Firstly, the suture process will take a long time, and secondly, the use of suture will cause damage to the stimulating function of the nerve, and the effect of nerve recovery is still unsatisfactory.

Method used

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  • Polycaprolactone (PCL) static spinning nerve conduit and preparation and application thereof
  • Polycaprolactone (PCL) static spinning nerve conduit and preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] (1) Weave polycaprolactone monofilament (diameter 0.1mm) into a mesh circular tube with an inner diameter of 2mm, set the length and set it into the rotating receiving circular tube of the electrospinning device, and the rotation speed is 50rpm;

[0030] (2) Dissolve PCL in chloroform / methanol solution (chloroform:methanol volume ratio=4:1), and stir to form a PCL / chloroform / methanol solution with a mass percentage of PCL of 10%.

[0031] (3) Electrospinning of PCL / chloroform / methanol solution, the flow rate is 1.5mL / h, the applied voltage value is 10kv, and the receiving distance is 10cm;

[0032] (4) After the electrospinning is finished, the nerve guide is removed and packaged and sterilized before it can be used for the repair of the peripheral nervous system.

Embodiment 2

[0034] (1) Weave polyglycolic acid (PGA) 70dtex / 24f fibers into a mesh circular tube with an inner diameter of 3 mm, set the length and set it into the rotating receiving circular tube of the electrospinning device, and rotate at a speed of 40 rpm;

[0035] (2) Dissolve PCL in chloroform / methanol solution (chloroform:methanol volume ratio=3:1), and stir to form a 6% by mass PCL / chloroform / methanol solution.

[0036] (3) Electrospinning of PCL / chloroform / methanol solution, the flow rate is 1mL / h, the applied voltage value is 30kv, and the receiving distance is 18cm;

[0037] (4) After the electrospinning is finished, the nerve guide is removed and packaged and sterilized before it can be used for the repair of the peripheral nervous system.

Embodiment 3

[0039] (1) Weave polyglycolide lactide (PGLA) monofilaments into a mesh-shaped circular tube with an inner diameter of 2.5 mm, and then insert it into the rotating receiving circular tube of the electrospinning device after the length is fixed, and the rotation speed is 35 rpm;

[0040] (2) Dissolve PCL in chloroform / methanol solution (chloroform:methanol volume ratio=3.5:1), and stir to form a 7% by mass PCL / chloroform / methanol solution.

[0041] (3) Electrospinning of PCL / chloroform / methanol solution, the flow rate is 0.8mL / h, the applied voltage value is 15kv, and the receiving distance is 13cm;

[0042] (4) After the electrospinning is finished, the nerve guide is removed and packaged and sterilized before it can be used for the repair of the peripheral nervous system.

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Abstract

The invention relates to a polycaprolactone (PCL) static spinning nerve conduit and preparation and application thereof. The polycaprolactone static spinning nerve conduit comprises an inner layer and an outer layer, wherein the inner layer is a reticular conduit made of high molecular degradable fibers, and the outer layer is a three-dimensional reticular structure which has high specific surface area and high porosity and is made of PCL sub-micron fibers jetted by adopting a static spinning method. The preparation of the verve conduit comprises the following steps: (1) weaving the high molecular degradable fibers and sleeving the high molecular degradable fibers into a static spinning device; (2) dissolving the PCL into a trichloromethane / methanol solution, and stirring the mixture; (3) performing static spinning of the PCL / trichloromethane / methanol solution; and (4) after the static spinning, taking off the nerve conduit, and packaging and sterilizing the nerve conduit. The nerve conduit is also a tissue engineering bracket for nerve reconstruction while the conduit wall plays a role in guiding and conveying nutrients; and the preparation method has the advantages of simple operation, low cost, no pollution to the environment, and high economic benefit, and is applied to restoring the peripheral nervous system.

Description

technical field [0001] The invention belongs to the field of nerve guide and its preparation and application, in particular to polycaprolactone PCL electrospinning nerve guide and its preparation and application. Background technique [0002] The first surgical operation to repair damaged nerves can be traced back to the 13th century [Li, Multi-layered, semi-permeable conduit for nerve regeneration, U.S. Pat. No. 4963146]. Making repairs is also a difficult problem in the medical world and has been a mountain that scientists have been trying to conquer. [0003] When a nerve is torn and severely damaged, the nerve can be stitched back together microsurgery as long as the nerve is not damaged. But if the nerve is partially lost during the injury, there will be some distance between the two ends of the damaged nerve. If the defect distance is not very long, such as within 1.5cm [Dellon et al., Bioabsorbable surgical device fortreating nerve defects, U.S. Pat. No. 4870966], i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L29/12A61L29/06A61F2/04
Inventor 杨庆陈璐刘天郯志清沈新元杨科
Owner DONGHUA UNIV
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