Zedoary turmeric oil adhesive membrane for external application and preparation method thereof

Abstract

The invention relates to a zedoary turmeric oil adhesive membrane for external application, which comprises a backing layer and a drug membrane adhered to the backing layer. The drug membrane is prepared by the following steps that: chitosan and an acetic acid solution with the mass fraction of between 0.5 and 5 percent are mixed to prepare a 15 to 25 mg / ml chitosan solution, then the chitosan solution is mixed evenly with a 30 and 40 mg / ml polyvinyl alcohol water solution to obtain a mixed solution, the mass ratio of the chitosan and polyvinyl alcohol is 1: 0.2-1: 5, then glycerol and zedoary turmeric oil are added into the mixed solution, a surfactant is added into the mixed solution, the mixed solution is stirred for 5 to 35 min and is kept stand for defoaming, the membrane spreading is performed, and the drug membrane can be obtained by drying in a baking oven with a temperature of between 20 and 45 DEG C. The adhesive membrane has good sustained control function; the adhesive membrane can be directly pasted on afflicted parts and play a role in positioning; and the adhesive membrane improves the effective concentration of medicaments and prolongs the acting time of the medicaments, improves the bioavailability, furthest reduces the toxic side effect at the same time, and can well play clinical roles of the zedoary turmeric oil in antitumor, skin disease treatment and the like.

Description

technical field [0001] The invention relates to an external application film of zedoary oil and a preparation method thereof. Background technique [0002] Curcuma phaaeocaulis Valeton, C.kwangsiensis S.G.LeeetC.F.Liang and C.wenyujin Y.H.ChenetC.Ling are the dried rhizomes of Zingiberaceae plants. Curcuma zedoary is pungent, bitter, and warm, and returns to the liver and spleen meridian. It has the effects of promoting qi and breaking blood, eliminating accumulation and relieving pain. It is clinically used for lumps in the abdomen, blood stasis, amenorrhea, dyspepsia, distending pain, early cervical cancer, etc. Through in-depth research on the pharmacological activity, mechanism of action, in vivo process, and toxic and side effects of zedoary oil, it is confirmed that zedoary oil has very broad development prospects. Studies have shown that turmeric oil has remarkable effects in anti-tumor and anti-thrombosis, and has anti-early pregnancy, anti-bacterial, liver-protect...

AI Technical Summary

Problems solved by technology

[0003] At present, the dosage forms used or developed include injections, eye drops and suppositories. Although the above-mentioned preparations have certain effects in the treatment of cervical cancer, liver cancer and cardiovascular diseases, they are inconvenient to use for the treatment of skin diseases, and the effect is not good. obvious

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