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Skin external preparation in the form of water-in-oil emulsion comprising ceramide

A water-in-oil emulsion, ceramide technology, applied in cosmetic preparations, cosmetic preparations, pharmaceutical formulas, etc.

Inactive Publication Date: 2009-10-21
POLA CHEM INDS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, external preparations in the form of water-in-oil emulsions comprising organomodified clay minerals and crosslinked silicones are completely unknown

Method used

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  • Skin external preparation in the form of water-in-oil emulsion comprising ceramide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0084] The external preparation of the present invention is made into a cream according to the following formulation. First, components (A) and (B) were preheated to 70° C., and component (B) was added to component (A) under stirring to prepare crude liposomes. Subsequently, this crude liposome was processed with an extruder, followed by granulation, whereby a liposome-dispersed liquid was obtained. Add the liposome-dispersed liquid to component (C) heated to 80°C, and gradually add the mixture to component (D), which has become a gel, stir to emulsify the mixture, then in Cooling with stirring, thereby obtaining Cream 1 in the form of a water-in-oil emulsion having liquid droplets in which liposomes are contained in the oil phase (liposome-containing water-in-oil emulsion form). The same procedure was repeated except that ordinary simethicone (uncrosslinked) was used instead of "Silicone KSG-16", thereby preparing Cream 2 in the form of a water-in-oil emulsion containing lip...

Embodiment 2

[0138] The same test as in Test Example 1 was carried out for creams (creams 3 to 5) prepared using different kinds of ceramides in cream 1. Table 5 shows the evaluation results obtained by the procedure of Test Example 1. The results show an improved ceramide-releasing effect in the case of all types of ceramides.

[0139] Table 4

[0140] Component mass%

[0141] (A)

[0142] Ceramides described in Table 4 0.5

[0143] Phytosterol 0.5

[0144] (Phytosterol S Tama Biochemical Co., Ltd.; mixture of β-sitosterol, stigmasterol, and campesterol)

[0145] Hydrogenated Lecithin 1

[0146] Macadamia Oil 1

[0147] "Eldew PS-203" 4

[0148] (Ajinomoto Co., Inc.; N-lauroyl glutamate di(phytosteryl ester / octyldodecyl ester)

[0149] 1,3-Butanediol 10

[0150] Glycerin 10

[0151] (B)

[0152] water 73

[0153] (subtotal) 100

[0154] (C)

[0155] Squalane 2

[0156] Triglyceride Isocaprylate 1

[0157] Sucrose fatty acid ester 0.2

[0158] "Eldew PS-203" 4

[0159] S...

Embodiment 3

[0177]The same test as in Test Example 1 was carried out for creams (creams 6 to 8) prepared using different kinds of phospholipids in cream 1. Table 7 shows the evaluation results obtained through the procedure of Test Example 1. The results show improved ceramide release in the case of all classes of phospholipids.

[0178] Table 6

[0179] Component mass%

[0180] (A)

[0181] "Ceramide-TIC" 0.5

[0182] Phytosterol 0.5

[0183] (Phytosterol S Tama Biochemical Co., Ltd.; mixture of β-sitosterol, stigmasterol, and campesterol)

[0184] Phospholipids described in Table 6 1

[0185] Macadamia Oil 1

[0186] "Eldew PS-203" 4

[0187] (Ajinomoto Co., Inc.; N-lauroyl glutamate di(phytosteryl ester / octyldodecyl ester)

[0188] 1,3-Butanediol 10

[0189] Glycerin 10

[0190] (B)

[0191] water 73

[0192] (subtotal) 100

[0193] (C)

[0194] Squalane 2

[0195] Triglyceride Isocaprylate 1

[0196] Sucrose fatty acid ester 0.2

[0197] "Eldew PS-203" 4

[0198] Si...

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Abstract

The present invention provides a technology for delivering a ceramide across the horny layer to sufficiently exert the effects of the ceramide. Specifically, the present invention provides a skin external preparation comprising a ceramide, which enables sufficient delivery of a ceramide comprised in the skin external preparation across the horny layer to near the dermis when the skin preparation is applied on the skin surface. A skin external preparation of the present invention comprises a ceramide, an organically modified clay mineral, a diester of N-acylglutamic acid, and a phytosterol as essential components and in the form of water-in-oil emulsion.

Description

technical field [0001] The present invention relates to external preparations, more particularly to external preparations in the form of water-in-oil emulsions. Background technique [0002] A major problem in the field of dermatology today is the exponential growth of atopic dermatitis. The cause of atopic dermatitis is not clarified in detail, but it is considered to be caused by various factors such as allergic reaction of the skin to various chemical substances. Thus, skin care is required to prevent chemical substances from being introduced into the living body. However, ingredients contained in topical preparations administered for skin care can provide irritation to the skin. In order to prevent irritation, it is considered effective that the barrier function on the bottom of the stratum corneum is improved by releasing ceramide or the like through the stratum corneum to the vicinity of the dermis (Patent Documents 1 and 2). However, ceramides have low solubility t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/06A61K8/44A61K8/26A61K8/63A61K8/41A61K8/68
Inventor 赤塚秀贵清野绫子濑户匡人铃木将史
Owner POLA CHEM INDS