Method for preparing bone-like apatite controlled by thermodynamics

Abstract

The invention relates to a method for preparing bone-like apatite controlled by thermodynamics. Water micro-soluble calcium salts with a Ksp value larger than that of bone-like apatite, such as calcium sulphate or hydrate thereof and the like, are taken as raw materials and react in a water solution of a water-soluble phosphate, thus obtaining the bone-like apatite; the yield of the product is above 95 percent, and the molar ratio of Ca / P is consistent with the theoretical computation of the raw materials. The method is characterized in that the reaction process is thermodynamic spontaneous reaction controlled by thermodynamics instead of dynamics; therefore, reaction condition does not affect the final composition and property of the product, and the product is stable and has less impurities; the prepared nano bone-like apatite sizing material can be directly applied to preparing corresponding nano biomimetic composite bone repairing and substituting materials and the like or used for obtaining corresponding bone-like apatite powder after being dried.

Description

technical field

[0001] The invention relates to a method for preparing bone-like apatite, in particular to a method for preparing nano-bone-like apatite whose reaction is controlled by thermodynamics. Background technique

[0002] The hard tissue of the human body is mainly composed of organic collagen and inorganic mineral components, of which the inorganic mineral components are mainly nano-scale apatite crystals, accounting for about 65% to 90% of the total bone components. In addition, it also contains a small amount of carbonate ions, sodium ions, etc. As stated in the Chinese patent literature of "Preparation method of nano-hydroxyapatite powder with controllable crystallization degree" in the publication number CN101143718A, bone-like apatite (HA) has good bioactivity and biocompatibility, and the finer the particles , the torsional modulus, tensile modulus and tensile strength of the corresponding implant are higher, and the fatigue resistance is also improved accor...

Examples

Embodiment 1

[0024] Get 456g of trisodium phosphate dodecahydrate and add it into 3000 milliliters of deionized water to make a solution, add 345g of calcium sulfate dihydrate under stirring condition, and keep stirring to make it react. At the same time, 0.2 g of sodium bicarbonate was added to adjust the pH of the reaction system to 7, and the reaction system was reacted at 20° C. for 8 hours, then the stirring was stopped, and the mixture was left to age at room temperature for 48 hours. After aging, the supernatant was removed and washed at least 6 times with deionized water at 60°C. After washing, prepare a slurry with a water content of 70%. After the prepared slurry is dried at 80° C. to 100° C., infrared absorption spectrum (IR) and X-ray diffraction (XRD) analysis and calcium / phosphorus ratio detection are performed.

[0025] The test results are as follows:

[0026] 1. The calcium / phosphorus ratio in the prepared nano-apatite is 1.64, which is in line with the ratio of calcium ...

Embodiment 2

[0032] Get 380g of trisodium phosphate dodecahydrate and add it into 3000 milliliters of deionized water to make a solution, add 258g of calcium sulfate dihydrate under stirring condition, and keep stirring to make it react. At the same time, 0.16 g of sodium bicarbonate was added to adjust the pH of the reaction system to 7. After reacting at 20° C. for 8 hours, the stirring was stopped, and the reaction system was aged at room temperature for 48 to 72 hours. After aging, remove the supernatant and wash with deionized water at 60°C for at least 6 times. The yield reaches 98.5%. After the slurry was dried, the calcium-to-phosphorus ratio was tested to be 1.53.

Embodiment 3～12

[0034] Add different phosphates from the table below to 3000 ml of deionized water to make a solution, add calcium salt under stirring conditions, and keep stirring to make it react. At the same time, sodium bicarbonate was added to adjust the pH of the reaction system. After the reaction was completed, the stirring was stopped, and the mixture was aged at room temperature for 48 hours. After aging, remove the supernatant, and wash at least 6 times with deionized water at 60°C. Yields and Ca-P ratios are shown in Table 2.

[0035] The relevant parameter of table 2 embodiment 3~12

[0036]

technical field

[0001] The invention relates to a method for preparing bone-like apatite, in particular to a method for preparing nano-bone-like apatite whose reaction is controlled by thermodynamics. Background technique

[0002] The hard tissue of the human body is mainly composed of organic collagen and inorganic mineral components, of which the inorganic mineral components are mainly nano-scale apatite crystals, accounting for about 65% to 90% of the total bone components. In addition, it also contains a small amount of carbonate ions, sodium ions, etc. As stated in the Chinese patent literature of "Preparation method of nano-hydroxyapatite powder with controllable crystallization degree" in the publication number CN101143718A, bone-like apatite (HA) has good bioactivity and biocompatibility, and the finer the particles , the torsional modulus, tensile modulus and tensile strength of the corresponding implant are higher, and the fatigue resistance is also improved accor...

Examples

Embodiment 1

[0024] Get 456g of trisodium phosphate dodecahydrate and add it into 3000 milliliters of deionized water to make a solution, add 345g of calcium sulfate dihydrate under stirring condition, and keep stirring to make it react. At the same time, 0.2 g of sodium bicarbonate was added to adjust the pH of the reaction system to 7, and the reaction system was reacted at 20° C. for 8 hours, then the stirring was stopped, and the mixture was left to age at room temperature for 48 hours. After aging, the supernatant was removed and washed at least 6 times with deionized water at 60°C. After washing, prepare a slurry with a water content of 70%. After the prepared slurry is dried at 80° C. to 100° C., infrared absorption spectrum (IR) and X-ray diffraction (XRD) analysis and calcium / phosphorus ratio detection are performed.

[0025] The test results are as follows:

[0026] 1. The calcium / phosphorus ratio in the prepared nano-apatite is 1.64, which is in line with the ratio of calcium ...

Embodiment 2

[0032] Get 380g of trisodium phosphate dodecahydrate and add it into 3000 milliliters of deionized water to make a solution, add 258g of calcium sulfate dihydrate under stirring condition, and keep stirring to make it react. At the same time, 0.16 g of sodium bicarbonate was added to adjust the pH of the reaction system to 7. After reacting at 20° C. for 8 hours, the stirring was stopped, and the reaction system was aged at room temperature for 48 to 72 hours. After aging, remove the supernatant and wash with deionized water at 60°C for at least 6 times. The yield reaches 98.5%. After the slurry was dried, the calcium-to-phosphorus ratio was tested to be 1.53.

Embodiment 3～12

[0034] Add different phosphates from the table below to 3000 ml of deionized water to make a solution, add calcium salt under stirring conditions, and keep stirring to make it react. At the same time, sodium bicarbonate was added to adjust the pH of the reaction system. After the reaction was completed, the stirring was stopped, and the mixture was aged at room temperature for 48 hours. After aging, remove the supernatant, and wash at least 6 times with deionized water at 60°C. Yields and Ca-P ratios are shown in Table 2.

[0035] The relevant parameter of table 2 embodiment 3~12

[0036]

Images