Method for preparing zinc supplementing agent carboxymethyl chitosan oligosaccharide zinc

A technology of carboxymethyl chitosan and carboxymethyl chitosan, which is applied in the field of preparation of zinc supplements, can solve problems such as low absorption rate and stimulating effect, and achieve good safety and biological activity

Inactive Publication Date: 2009-11-04
江西豫章药业有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the zinc supplements on the market (such as zinc sulfate and zinc gluconate) have a certain stimulating effect on the stomach, and the absorption rate is not high. The complex prepared from carboxymethyl chitosan and zinc can also play a role in s

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] The preparation method of zinc supplement carboxymethyl chitosan oligosaccharide zinc: prepare 0.1mol / L ZnSO 4 100ml, adjust the pH to 6, add 4g of carboxymethyl chitosan oligosaccharide, control the reaction temperature at 40°C and keep stirring, react for 2h, precipitate with ethanol, filter and dry. The obtained carboxymethyl chitosan oligosaccharide zinc, wherein the content of zinc is 0.151mmol / g.

[0012] The preparation of carboxymethyl chitosan: take 15g chitosan and alkalinize it in 50% sodium hydroxide solution, then add 150ml isopropanol and stir, add 18g chloroacetic acid and react at 65°C for 2h, And, wash with 70% methanol several times, then dissolve in water, precipitate with acetone, filter, wash and filter repeatedly with absolute ethanol, and dry in vacuum to obtain carboxymethyl chitosan.

[0013] Wherein the preparation of carboxymethyl chitosan oligosaccharide: get 10g carboxymethyl chitosan in the there-necked flask, add 2% H in batches under sti...

Embodiment 2

[0015] The preparation method of zinc supplement carboxymethyl chitosan oligosaccharide zinc: prepare 0.1mol / L ZnSO 4 100ml, adjust the pH to 6, add 4g of carboxymethyl chitosan oligosaccharide, control the reaction temperature at 30°C and keep stirring, react for 2h, precipitate with ethanol, filter and dry. The obtained carboxymethyl chitosan oligosaccharide zinc, wherein the content of zinc is 0.138mmol / g.

[0016] The preparation of carboxymethyl chitosan: take 15g chitosan and alkalinize it in 50% sodium hydroxide solution, then add 150ml isopropanol and stir, add 18g chloroacetic acid and react at 65°C for 2h, And, wash with 70% methanol several times, then dissolve in water, precipitate with acetone, filter, wash and filter repeatedly with absolute ethanol, and dry in vacuum to obtain carboxymethyl chitosan.

[0017] Wherein the preparation of carboxymethyl chitosan oligosaccharide: get 10g carboxymethyl chitosan in the there-necked flask, add 2% H in batches under sti...

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Abstract

The invention relates to a method for preparing zinc supplementing agent carboxymethyl chitosan oligosaccharide zinc, which is characterized in that 10g of carboxymethyl chitosan is taken and put into a three-neck flask, and is added with 90ml of 2% H2O2 in batches when being stirred for full reaction until the carboxymethyl chitosan is completely dissolved; pH value is adjusted to be 7, the precipitation is filtered out, the product is washed, and filtrate and washing liquid are collected; the filtrate and the washing liquid are decompressed and concentrated, and then precipitated, filtered and washed by ethanol; finally, the product is processed by vacuum drying with the drying temperature controlled to be 60 DEG C. The invention has the advantages that the carboxymethyl chitosan is prepared after chitosan oligosaccharide is modified, so as to have the pharmacological actions of arrhythmia resistance, anticoagulation, infection resistance and the like; the carboxymethyl chitosan oligosaccharide zinc is natural modified product and has better safety and biological activity compared with other zinc supplementing agents.

Description

technical field [0001] The invention relates to a preparation method of a zinc supplement, in particular to a preparation method of a zinc supplement carboxymethyl chitosan oligosaccharide zinc. Background technique [0002] Oligochitosan is obtained by degrading chitosan, and its degree of polymerization is below 20. Chitosan is the deacetylation product of chitin, the second largest natural polymer polysaccharide in nature. The degree of deacetylation is generally greater than 60%. It is a rare alkaline polysaccharide in nature. In my country, chitosan has been approved as a health food. [0003] Oligochitosan not only has good water solubility and is easily absorbed, but also has a variety of physiological functions, such as antibacterial, antitumor, and antiinfection. Oligochitosan has good tissue compatibility, non-toxicity and non-antigenicity. Studies have shown that chitosan can promote the growth of bifidobacteria, regulate the metabolic activities of intestinal ...

Claims

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Application Information

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IPC IPC(8): C07H15/04C07H1/00C08B37/08A61K31/7028A61K31/722A61P3/02A23L1/304A61P9/06A61P7/02A61P31/00A61P37/02A61P35/00A23L33/16
Inventor 谢宇魏娅洪小伟杨莉
Owner 江西豫章药业有限公司
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