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Traditional Chinese medicine preparation

A technology of traditional Chinese medicine preparations and raw materials, which is applied in the field of medicine and can solve the problems of unretrieved gastrodin drugs, etc.

Active Publication Date: 2012-04-25
北京卓越同舟药物研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] After reviewing the literature and patents, gastrodin and ginsenoside Rb were not found 1 Compatible drugs

Method used

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  • Traditional Chinese medicine preparation
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Examples

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Effect test

Embodiment 1

[0023] Protective effect on glutamate-induced injury of cultured cortical neurons

[0024] Experimental drug: gastrodin solution (Kunming Pharmaceutical Group, Yunnan Province) preparation of the present invention (provided by the laboratory of Beijing Drug Development Co., Ltd.)

[0025] Experimental method: According to the reference method, 200umol / L sodium glutamate was added to the culture medium of nerve cells cultured in vitro for 8 days to act for 10min, and the dissecting solution (NaCl8g, KCl0.4g, Na2HPO4 7H2O0.18g, KH2PO40.03g, sucrose 3g, glucose 75g, Hepes 2.34g, add distilled water to 1000ML) and rinse once. Change the serum-free culture solution and continue to cultivate for 24 hours; add 20ul culture solution to the normal control group, rinse once with dissecting solution, change the serum-free culture solution and continue to cultivate for 24 hours; gastrodin solution 26mg / L, preparation of the present invention 26mg / L, each group takes medicine Add sodium g...

Embodiment 3

[0037] Effects on Trigeminal Neuralgia in Rats

[0038] Experimental animals: Wistar rats, weighing 200-220g.

[0039] Experimental drug: gastrodin liquid (Kunming Pharmaceutical Group, Yunnan Province); preparation of the present invention (provided by the laboratory of Beijing Drug Development Co., Ltd.)

[0040] Experimental method: Rats, both male and female, were randomly divided into groups, 10 in each group, administered to the rats according to the dosage of each group, the dosage was 10 mg / kg, 60 minutes after the administration, anesthetized with ether, and the abdominal position was fixed. Cut the hair on the head and neck, cut the skin, separate the muscles, expose the dura mater between the occipital bone and the first cervical vertebra, take 3ul of newly prepared penicillin G potassium with a micro-sampler, and put it in the lower left 1-2mm of the brain of the rat, the first About 1 mm above the left upper cervical spinous process, which is equivalent to the ca...

Embodiment 4

[0044] Protective effect on noise-induced ear vortex injury

[0045] Experimental drug: gastrodin liquid (Kunming Pharmaceutical Group, Yunnan Province); preparation of the present invention (provided by the laboratory of Beijing Drug Development Co., Ltd.)

[0046] Experimental animals: healthy guinea pigs with intact tympanic membranes and normal ear vortices, male, weighing 250-300g.

[0047]Experimental method: the guinea pigs are divided into normal group, noise exposure group, noise exposure+gastrodin solution group, noise exposure+preparation group of the present invention; the 4Khz masking narrowband noise that the AA30 type advanced pure tone audiometer sends is adopted as the noise source by tape recording, Amplified by a power amplifier of 107db, the noise exposure + gastrodin solution group, noise exposure + the preparation of the present invention group were placed in a soundproof box, the head was 15cm away from the noise source, and noise exposure was performed ...

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Abstract

The invention discloses a traditional Chinese medicine preparation which is characterized by being prepared from gastrodin and ginsenoside Rb1by the following compositions: a bulk drug comprises 10-500 of the gastrodin and 10-300 of the ginsenoside Rb1 according to the parts by weight; the bulk drug comprises 100-300 of the gastrodin and 50-200 of the ginsenoside Rb1 according to the parts by weight; and the bulk drug comprises 200 of the gastrodin and 100 of the ginsenoside Rb1 according to the parts by weight. Pharmacological experiment results prove that the injection preparation has a better pharmacological action.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a raw material drug comprising gastrodin and ginsenoside Rb 1 of traditional Chinese medicine preparations. Background technique [0002] Headache, vertigo, and dizziness are common clinical symptoms in neurology. Many diseases can cause headache, vertigo, and dizziness, such as vascular headache, migraine, neurasthenia, craniocerebral trauma, Meniere's disease, vestibular disorders, and spinal cord disorders. Vertigo and dizziness caused by basilar artery insufficiency, dizziness and often tinnitus, hearing impairment and autonomic dysfunction symptoms, which affect work and daily life in severe cases. Therefore, the development of drugs for the treatment of the above symptoms will bring great benefits to many patients. [0003] Gastrodin has various pharmacological effects, can restore the imbalance between the excitation and inhibition process of the cerebral co...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7034A61K31/704A61P25/00
Inventor 王爱民李伟
Owner 北京卓越同舟药物研究院有限公司
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