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A technology of aescin and saponin, which is applied in the field of preparation of aescin, and can solve the problems of low yield and low purity of the extraction method of aescin
Inactive Publication Date: 2009-12-16
NANJING ZELANG MEDICAL TECH
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[0004] In the prior art, the extraction me
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Embodiment 1
[0013] Take 10Kg of rhizome powder of Aesculus aesculus, add 3 times the amount of 20% ethanol to reflux and extract once for 1.5 hours, combine the extracts, filter, recover ethanol under reduced pressure and concentrate, add petroleum ether to degrease, add water to the residue 10L, add an equal amount of water-saturated n-butanol to extract twice, combine the n-butanol liquid, recover and concentrate under reduced pressure, add 95% ethanol to dissolve the residue, add acetone to recrystallize, filter, wash, and dry to obtain light yellow Aescin 8.2g, HPLC detection purity is 97.3%.
Embodiment 2
[0015] Take 10Kg of rhizome powder of Aesculus aesculi, add 12 times the amount of 90% ethanol to reflux and extract 5 times, each time for 1.5 hours, combine the extracts, filter, recover the ethanol under reduced pressure and concentrate, add petroleum ether to degrease, add water to the residue Make up to 10L, add an equal amount of water-saturated n-butanol to extract 8 times, combine the n-butanol solution, recover and concentrate under reduced pressure, add 95% ethanol to dissolve the residue, add acetone to recrystallize, filter, wash, and dry to obtain Pale yellow aescin 25.5g, HPLC detection purity is 91.9%.
Embodiment 3
[0017] Take 10Kg of rhizome powder of Aesculus chinensis, add 8 times the amount of 70% ethanol to reflux and extract 3 times, each time for 1.5 hours, combine the extracts, filter, recover the ethanol under reduced pressure and concentrate, add petroleum ether to degrease, add water to the residue Make up to 10L, add an equal amount of water-saturated n-butanol to extract 4 times, combine the n-butanol liquid, recover and concentrate under reduced pressure, add 95% ethanol to dissolve the residue, add acetone to recrystallize, filter, wash, and dry to obtain Pale yellow aescin 18.8g, HPLC detection purity is 98.9%.
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Abstract
The invention relates to a preparation method of paris polyphylla saponin, which has simple operation, low pollution and less equipment investment; the processing steps are as follows: paris polyphylla root-stack coarse powder is taken out, 3-12 times of 20-90 percent of ethanol is added for carrying out reflux extraction for 1-5 times, each time is carried out for 1.5 hours, the extracting solution is mixed, the filtration is carried out, the ethanol is recycled and concentrated by compression, petroleum ether degreasing agents are added, water is added in residue for metering the volume with one time volume of medicinal materials, water saturation normal butanol with equal volume is added for carrying out extraction for 2-8 times, the normal butanol liquid is mixed, and is recycled and concentrated by compression, the residue is dissolved by adding 95 percent of ethanol, pyroacetic spirit is added for recrystallization, and the paris polyphylla saponin is obtained by filtration, washing and drying. By adopting the method to prepare the paris polyphylla saponin, the product purity is high, so as to be easy to realize industrialization enlargement.
Description
technical field [0001] The invention relates to a preparation method of aescin, in particular to a method for extracting aescin from plants. Background technique [0002] Aescin is derived from the dried rhizome of Aescin, a plant of the Liliaceae family. It has the effects of clearing away heat and detoxification, reducing swelling and relieving pain. Folks are mostly used to treat unknown swollen poison and poisonous snake bites, as well as mumps, tonsillitis, sore throat, mastitis, bruises, etc. [0003] Aescin is an active ingredient contained in the traditional Chinese medicine Aescin, which has various pharmacological effects. [0004] In the prior art, the extraction method of Aescin has low yield and low purity. Contents of the invention [0005] The technical problem to be solved by the present invention is to provide a method for preparing aescin which is beneficial to large-scale production operation and has high product purity. [0006] In order to solve the...
Claims
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