Hydrogel tissue filling agent for ophthalmology and preparation method thereof

Abstract

The invention relates to a novel hydrogel tissue filling agent for ophthalmology and a preparation method thereof. The hydrogel tissue filling agent for ophthalmology uses monomer vinyl pyrrolidone and methyl methacrylate as raw materials and is prepared by copolymerization according to the mass ratio of vinyl pyrrolidone: methyl methacrylate being equal to 50 to 95%: 5 to 50%. Under an airtight condition, initiator is dissolved in the monomer vinyl pyrrolidone, monomer methyl methacrylate and crosslinking agent are added successively to fully mix the system by stirring, the system is filtered, the filter liquor is poured into a module to be heated to carry out reaction, then dry copolymer gel is obtained; the copolymer gel is hydrolyzed; and repeated washing and swelling, gradient sodium chloride solution dehydration, high temperature sterilization and drying are carried out on the gel after hydrolyzation. The novel hydrogel tissue filling agent for ophthalmology in the invention has higher degree of volume swelling and good compression resistance and good tolerability and biocompatibility in eyes, and can be self-expanding, thereby being expected to have good cosmetic results and fewer complications.

Description

technical field

[0001] The invention relates to a novel ophthalmic hydrogel tissue filler and a preparation method thereof. Background technique

[0002] Orbital development continues from birth through adolescence, and normal development of the bony orbit is dependent on the presence of a normal eyeball. In clinical work, eyeballs are often enucleated due to severe ocular trauma, intraocular malignant tumors, and blindness and painful eyes caused by various eye diseases. In ophthalmic surgery, the average enucleation rate is 218 / 100,000. After enucleation in adults, post-enucleation syndrome often results. After children enucleate the eyeball, it will not only lead to enucleation syndrome, but also the orbital bone will lose the stimulating effect of the eyeball, resulting in retardation of orbital bone development, and severe facial deformities. Since Mules carried out eye enucleation in 1885 and Frost reported enucleation in 1886, many scholars have conducted a lot of ...

Examples

Embodiment 1

[0024] (1) The bulk polymerization method is adopted, with AIBN as the initiator, allyl MA and EGDM as the crosslinking agent, and NVP and MMA as the monomers to carry out the copolymerization reaction. The total raw material weight is 4g, the monomer composition is NVP / MMA=75 / 25, the amount of crosslinking agent allyMA / EGDM=0.19% / 0.026%, and the amount of initiator is 0.05%. In the triangular grinding mouth flask, according to the predetermined ratio, dissolve the initiator and cross-linking agent in NVP, then add MMA, stir to make all components mix completely. The monomer mixture was filtered, the filtrate was poured into a mold, and reacted in a constant temperature incubator at 80° C. for 24 hours.

[0025] (2) Take the sample synthesized in step (1), fully swell in physiological saline for 72 hours, place in a container with 20% NaOH solution (about 20ml), and react at a constant temperature at 70°C for 1 hour.

[0026] (3) Take the sample treated in step (2), wash it i...

Embodiment 2

[0028](1) The bulk polymerization method is adopted, with BPO as the initiator, allyl MA and EGDM as the crosslinking agent, and NVP and MMA as the monomers to carry out the copolymerization reaction. The total raw material weight is 4g, the monomer composition is NVP / MMA=80 / 20, the crosslinking agent addition allyMA / EGDM=0.38% / 0.052%, and the initiator dosage is 0.2%. In the triangular grinding mouth flask, according to the predetermined ratio, dissolve the initiator and cross-linking agent in NVP, then add MMA, stir to make all components mix completely. The monomer mixture was filtered, and the filtrate was poured into a mold, and reacted in a constant temperature incubator at 90° C. for 12 hours.

[0029] (2) Take the sample synthesized in step (1), fully swell in saline for 72 hours, place it in a container with 30% NaOH solution (about 20ml), and react at a constant temperature at 80°C for 4 hours.

[0030] (3) With step (3) in embodiment 1. The volume swelling degree ...

Embodiment 3

[0032] (1) The bulk polymerization method is adopted, with AIBN as the initiator, allyl MA and EGDM as the crosslinking agent, and NVP and MMA as the examples to carry out the copolymerization reaction. The total raw material weight is 4g, the monomer composition is NVP / MMA=65 / 35, the amount of crosslinking agent added is allyMA / EGDM=0.19% / 0.026%, and the amount of initiator is 0.08%. In the triangular grinding mouth flask, according to the predetermined ratio, dissolve the initiator and cross-linking agent in NVP, then add MMA, stir to make all components mix completely. The monomer mixture was filtered, and the filtrate was poured into a mold, and reacted in a constant temperature incubator at 80° C. for 24 hours.

[0033] (2) Take the sample synthesized in step (1), fully swell in normal saline for 72 hours, place it in a container with 10% NaOH solution (about 20ml), and react at a constant temperature at 60°C for 10 hours.

[0034] (3) With step (3) in embodiment 1. The...

technical field

[0001] The invention relates to a novel ophthalmic hydrogel tissue filler and a preparation method thereof. Background technique

[0002] Orbital development continues from birth through adolescence, and normal development of the bony orbit is dependent on the presence of a normal eyeball. In clinical work, eyeballs are often enucleated due to severe ocular trauma, intraocular malignant tumors, and blindness and painful eyes caused by various eye diseases. In ophthalmic surgery, the average enucleation rate is 218 / 100,000. After enucleation in adults, post-enucleation syndrome often results. After children enucleate the eyeball, it will not only lead to enucleation syndrome, but also the orbital bone will lose the stimulating effect of the eyeball, resulting in retardation of orbital bone development, and severe facial deformities. Since Mules carried out eye enucleation in 1885 and Frost reported enucleation in 1886, many scholars have conducted a lot of ...

Examples

Embodiment 1

[0024] (1) The bulk polymerization method is adopted, with AIBN as the initiator, allyl MA and EGDM as the crosslinking agent, and NVP and MMA as the monomers to carry out the copolymerization reaction. The total raw material weight is 4g, the monomer composition is NVP / MMA=75 / 25, the amount of crosslinking agent allyMA / EGDM=0.19% / 0.026%, and the amount of initiator is 0.05%. In the triangular grinding mouth flask, according to the predetermined ratio, dissolve the initiator and cross-linking agent in NVP, then add MMA, stir to make all components mix completely. The monomer mixture was filtered, the filtrate was poured into a mold, and reacted in a constant temperature incubator at 80° C. for 24 hours.

[0025] (2) Take the sample synthesized in step (1), fully swell in physiological saline for 72 hours, place in a container with 20% NaOH solution (about 20ml), and react at a constant temperature at 70°C for 1 hour.

[0026] (3) Take the sample treated in step (2), wash it i...

Embodiment 2

[0028](1) The bulk polymerization method is adopted, with BPO as the initiator, allyl MA and EGDM as the crosslinking agent, and NVP and MMA as the monomers to carry out the copolymerization reaction. The total raw material weight is 4g, the monomer composition is NVP / MMA=80 / 20, the crosslinking agent addition allyMA / EGDM=0.38% / 0.052%, and the initiator dosage is 0.2%. In the triangular grinding mouth flask, according to the predetermined ratio, dissolve the initiator and cross-linking agent in NVP, then add MMA, stir to make all components mix completely. The monomer mixture was filtered, and the filtrate was poured into a mold, and reacted in a constant temperature incubator at 90° C. for 12 hours.

[0029] (2) Take the sample synthesized in step (1), fully swell in saline for 72 hours, place it in a container with 30% NaOH solution (about 20ml), and react at a constant temperature at 80°C for 4 hours.

[0030] (3) With step (3) in embodiment 1. The volume swelling degree ...

Embodiment 3

[0032] (1) The bulk polymerization method is adopted, with AIBN as the initiator, allyl MA and EGDM as the crosslinking agent, and NVP and MMA as the examples to carry out the copolymerization reaction. The total raw material weight is 4g, the monomer composition is NVP / MMA=65 / 35, the amount of crosslinking agent added is allyMA / EGDM=0.19% / 0.026%, and the amount of initiator is 0.08%. In the triangular grinding mouth flask, according to the predetermined ratio, dissolve the initiator and cross-linking agent in NVP, then add MMA, stir to make all components mix completely. The monomer mixture was filtered, and the filtrate was poured into a mold, and reacted in a constant temperature incubator at 80° C. for 24 hours.

[0033] (2) Take the sample synthesized in step (1), fully swell in normal saline for 72 hours, place it in a container with 10% NaOH solution (about 20ml), and react at a constant temperature at 60°C for 10 hours.

[0034] (3) With step (3) in embodiment 1. The...

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