Hydrophilic polymer the side chain of which is modified by lipoic acid and preparation and application thereof

A hydrophilic polymer and amphiphilic polymer technology, which is applied in the directions of non-active ingredients, such as medical preparations, educts, pharmaceutical formulations, etc. Efficiency, overcoming the effect of being easily leaked
CN101665569BActive Publication Date: 2011-09-28BRIGHTGENE BIO MEDICAL TECH (SUZHOU) CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
BRIGHTGENE BIO MEDICAL TECH (SUZHOU) CO LTD
Publication Date
2011-09-28

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Abstract

The invention discloses a hydrophilic polymer the side chain of which is modified by lipoic acid and preparation and application thereof. The hydrophilic polymer the side chain of which is modified by lipoic acid is an amphipathic polymer; the main chain of the amphipathic polymer is an hydrophilic polymer, and the side chain is a lipoic acid radical; the lipoic acid radical and a hydroxide radical or an amino group in the hydrophilic polymer are condensed to form an ester bond or an acidamide bond; crosslinking can be carried out by nano particles formed by the self assembly of the amphipathic polymer to obtain stable crosslinking polymer nano particles with sensitive reduction, so that the nano particles are not easy to dissociate both outside cells and in blood, thereby ensuring the stability of drugs encapsulated by the nano particles; the nano particles rapidly relieve crosslinking to dissociate once entering tumor cells, and then the drugs rapidly release to generate the high-efficiency therapeutic effect. The deficiencies that the drugs are easy to leak, the carrying efficiency is low, the release speed in the cells is slow and the like are solved.
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Description

technical field

[0001] The invention relates to a modified hydrophilic polymer, in particular to a hydrophilic polymer whose side chain is modified with lipoic acid. Background technique

[0002] Amphiphilic polymers can self-assemble in water to form polymer nanoparticles (Nanoparticles) by utilizing intermolecular interactions. Nanoparticles enter the body as a drug carrier, which can effectively reduce the phagocytosis of macrophages in the human reticuloendothelial system (RES), pass through the intercellular space, pass through the smallest capillaries and the blood-brain barrier (BBB) ​​in the human body, and be absorbed by cells and tissues . Nanoparticle drug carriers can control the release of drugs at targeted sites, reduce drug dosage, enhance drug efficacy and reduce drug toxicity. At the same time, the nanoparticle system can avoid the loss of drug activity, which is beneficial to the storage and transportation of drugs. Because of the many advantages of nano...

Claims

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