Medicinal composition for anti-stroke and anti-sequelae thereof, improving heart cerebral ischemia, preparation process and preparation thereof

A technology of cardio-cerebral ischemia and composition, which is applied in the directions of drug combination, medical preparations containing active ingredients, food preparation, etc., can solve the problems of unsatisfactory long-term treatment effect and patients should not take it for a long time, and achieve the protection of cerebral ischemia. , to facilitate quality control, to avoid the effect of a single curative effect

Inactive Publication Date: 2010-03-31
石林平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the western medicines used for anti-stroke are mainly thrombolytic drugs and channel blockers, but most of them ha

Method used

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  • Medicinal composition for anti-stroke and anti-sequelae thereof, improving heart cerebral ischemia, preparation process and preparation thereof
  • Medicinal composition for anti-stroke and anti-sequelae thereof, improving heart cerebral ischemia, preparation process and preparation thereof
  • Medicinal composition for anti-stroke and anti-sequelae thereof, improving heart cerebral ischemia, preparation process and preparation thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The preparation technology of embodiment 1 medicinal composition

[0021] Add 3 times the amount of 90% ethanol to the chuanxiong angelica powder and soak for 8 hours, then put it in a percolator, slowly carry out percolation, and continue to add ethanol until the percolation liquid is colorless, and the percolation liquid is decompressed to recover ethanol and concentrate When the relative density is 1.05~1.30 (50°C), let it cool down, add a total of 3 times the amount of 95% ethanol in 3 equal amounts to dissolve 3 times, combine the ethanol liquid obtained three times, recover the ethanol under reduced pressure and concentrate until the relative density is 1.10~ 1.30 (50°C), get the extract of Angelica chuanxiong, set aside;

[0022] The natural borneol is added to the above extract and dissolved to obtain the medicinal composition.

Embodiment 2

[0023] The preparation technology of embodiment 2 pharmaceutical compositions

[0024] Add 10 times the amount of 95% ethanol to Chuanxiong angelica powder and decoct 3 times, each decocting time is 2 hours, combine the three extracts, recover the ethanol under reduced pressure and concentrate to a relative density of 1.05-1.30 (50°C), divide into three times, etc. Add a total of 3 times the amount of 95% ethanol to dissolve 3 times, combine the alcohol solutions, recover the ethanol under reduced pressure and concentrate to a relative density of 1.10-1.30 (50°C), to obtain the extract of Angelica chuanxiong, which is set aside;

[0025] The natural borneol is added to the above extract and dissolved to obtain the medicinal composition.

Embodiment 3

[0026] Embodiment 3 oral tablet

[0027] Medicinal composition 0.01~0.30g / tablet

[0028] Magnesium stearate 0.1-0.3 mg / tablet

[0029] Sodium carboxymethyl starch 4~12 mg / tablet

[0030] Microcrystalline cellulose 50-100mg / tablet

[0031] Mix the medicinal composition with sodium carboxymethyl starch and microcrystalline cellulose, sieve, mix well, add an appropriate amount of water or ethanol of appropriate concentration to granulate, after drying, granulate, add an appropriate amount of stearic acid Magnesium, the granules are then compressed into tablets using punches of appropriate diameter.

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Abstract

The invention provides a medicinal composition for anti-stroke and anti-sequelae thereof, improving heart cerebral ischemia, a preparation process and a preparation thereof. The traditional Chinese medicine of the present invention compound function invigorating blood circulation and moving qi, dispelling wind and pain relieving of Ligusticum wallichii, function enriching blood and invigorating blood circulation, menstruation regulating and pain relieving of Chinese angelica, function enlightening and waking up the spirit, heat-clearing and pain relieving of natural borneol. The three medicinecompatible has efficacy of invigorating blood circulation and blood-nourishing, enlightening and tranquillizing, eliminating obstruction and pain relieving, which can be used to prepare medicine andhealth products for preventing and treating apoplexy, sequelae of apoplexy, vascular senile dementia, memory improvement, cerebrovascular permeability improvement, and for treating various ischemic cardiovascular and cerebrovascular diseases such as angina petoris. The invention also provides preparation method of medicinal composition and all the acceptable medicinal preparation.

Description

Technical field: [0001] The invention belongs to the field of traditional Chinese medicine development, and relates to a pharmaceutical composition for resisting apoplexy and its sequelae, and improving heart and brain ischemia, as well as its preparation process and preparation. The medicinal ingredients of Ligusticum chuanxiong total alkaloids, total organic acids of chuanxiong, total lactones of chuanxiong, total organic acids of angelica, total lactones of angelica and natural borneol are used as the main medicinal ingredients for the preparation of treatment and prevention of stroke, stroke sequelae, vascular old age Dementia, improving memory and cerebrovascular permeability, as well as the application of drugs for the treatment of angina pectoris and other functions. Background technique: [0002] Stroke, also known as cerebrovascular accident or cerebral apoplexy, is a type of disease with sudden coma, unconsciousness, accompanied by crooked mouth and eyes, speech di...

Claims

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Application Information

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IPC IPC(8): A61K36/236A61P9/10A23L1/30A61K31/045A23L33/105
Inventor 石林平
Owner 石林平
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