Material prepared from purely natural material and used for wounds

A biomedical material and wound technology, applied in the field of medical devices, can solve the problems of skin and wound irritation, easy to produce allergic reactions, etc.

Inactive Publication Date: 2010-05-05
SHENZHEN LANDO BIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The band-aid absorbs water is the water-absorbing pad. At present, the material of the water-absorbing pad is mainly non-woven fabric, and then compounded with a layer of polyethylene porous film. and wound irritation, prone to allergic reactions

Method used

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  • Material prepared from purely natural material and used for wounds
  • Material prepared from purely natural material and used for wounds
  • Material prepared from purely natural material and used for wounds

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1: Silk fibroin removes sericin

[0038] (1) Remove sericin. 20g Na 2 CO 3 Dissolve in 4L of water, heat to 100°C, add 75g silkworm reeled silk, keep the solution slightly boiling, and keep stirring. Pour off the solution after 1 hour, cool the boiled silk fibroin naturally, rinse it with deionized water, put it in an oven for 24 hours, and dry it at 50°C for later use.

[0039] (2). Dissolving silk fibroin. Take 44.4g CaCl 2 , 46mL ethanol, 57.6mL deionized water to make a mixed solution, put 15g dried silk fibroin in this solution. After fully immersing the silk fibroin in the solution, heat it in a water bath at 80°C and stir to dissolve it. After 1 hour, the silk fibroin is completely dissolved, stop heating and stirring, and naturally cool the silk fibroin solution to room temperature.

[0040] (3). Dialysis of silk fibroin solution. Pour the cooled silk fibroin solution into a dialysis bag (8000-10000Da), dialyze with tap water at room temperatu...

Embodiment 2

[0046] Embodiment 2 prepares absorbent pad or hemostatic sponge by silk fibroin and chitosan:

[0047] (1). Prepare 0.2M acetic acid solution. Dissolve 1.2 g of acetic acid in deionized water and titrate to 100 mL to obtain a 0.2 M acetic acid solution.

[0048] (2). Prepare 3% chitosan solution. Take 40mL of acetic acid solution and dissolve 1.2g of chitosan to obtain a light yellow viscous solution.

[0049](3). Prepare silk fibroin / chitosan mixed solution. Prepare a silk fibroin / chitosan mixed solution, the ratio of the two is 1:1, and stir for 15 minutes.

[0050] (4). Mold molding, freeze-drying. The silk fibroin / chitosan mixed solution was poured into different polytetrafluoroethylene molds, the samples were frozen at -20°C for 24h, and then freeze-dried for 48h (-54°C, 80Pa).

[0051] (5). Methanol treatment. The freeze-dried sample was taken out from the mold, soaked in methanol for 2-6 hours, poured off the methanol, and freeze-dried for 48 hours to remove resid...

Embodiment 3

[0053] Embodiment 3: Absorbent pad or hemostatic sponge prepared by silk fibroin and dextran.

[0054] (1). Prepare 1% silk fibroin solution. Take 0.4g silk fibroin and dissolve it in 40ml deionized water to obtain a viscous solution.

[0055] (2). Prepare 1% dextran solution. Take 40mL of deionized water and dissolve 0.4g of dextran to obtain a viscous solution.

[0056] (3). Prepare silk fibroin / dextran mixed solution. The above two solutions were mixed according to the volume ratio of 1:1, and stirred evenly.

[0057] (4). Freeze-dried molding. The silk fibroin / dextran solution was poured into the mold, and the mold containing the samples was frozen at -20°C for 24 hours, and then freeze-dried for 48 hours.

[0058] (5). Methanol treatment. The freeze-dried sample was taken out from the mold, soaked in methanol for 2-6 hours, poured off the methanol, and freeze-dried for 48 hours to remove residual methanol. Finally get the silk fibroin / glucan medical material we nee...

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Abstract

The invention relates to a material prepared from a purely natural material and used for wounds. The material is prepared by compounding fibroin protein or collagen protein and chitosan or alginic acid or glucan or hyaluronic acid high molecular polysaccharide. All the high molecular raw materials have favorable biologic compatibility and are widely applied to the fields of tissue engineering, medical appliances or medical auxiliary materials and the like.

Description

technical field [0001] The invention belongs to the field of medical equipment. The invention relates to a pure natural composite biomedical material used for wound treatment and a wound absorbent pad or hemostatic sponge prepared from the material. Background technique [0002] Absorbent pads or hemostatic sponges are necessary sanitary materials for families, hospitals, and clinics. Absorbent pads or tampons have the same properties, differing only in size and use. The absorbent pad is mainly used as the part of the band-aid in contact with the wound, and is mainly used for hemostasis, anti-inflammation or healing of acute small wounds. The hemostatic sponge is mainly used to absorb bleeding and wound exudate when a large wound is bleeding, and it also plays the role of auxiliary treatment such as hemostasis and anti-inflammation. Therefore, absorbent pads and hemostatic sponges are required to have good water absorption to absorb blood and wound exudate. [0003] The ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/32A61L15/28
Inventor 佘振定谭荣伟王明波
Owner SHENZHEN LANDO BIOMATERIALS
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