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Drug release mechanism based fluorine-containing dental restorative material

A technology of restorative materials and mechanisms, applied in dentistry, medical science, dental preparations, etc., can solve the problems of unstable release of fluorine from inorganic fluoride salts, reduction of overall strength, toughness and wear resistance of composite resins, etc., to achieve stable release, relative Good capacitance and the effect of reducing the wear rate

Inactive Publication Date: 2012-08-22
江苏南田工机有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The technical problem to be solved by the present invention is to solve the problem of unstable release of fluorine from inorganic fluorine salts in the existing fluorine-doped composite resins for caries filling, and the impact on the composite resin caused by the naked doping of inorganic fluorine salts. In order to solve the problem of reducing the overall strength, toughness and wear resistance, a new fluorine-doped composite resin material for caries filling is developed to help prevent secondary caries

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Weigh 10.00 grams of fluorine-loaded zirconia nanotubes, and 50.00 grams of barium strontium boron glass powder, and 40.00 grams of borosilicate glass powder, and mix the above three components uniformly by mechanical stirring to make a total weight of 100.00 grams of nano-inorganic powders containing multiple components, set aside.

[0029] 2.50 grams of medical-grade silane coupling agent KH-570 were hydrolyzed under the action of acetic acid, and 40 milliliters of hydroalcoholic solution was added. The pre-mixed nano-inorganic powder containing multiple components is dispersed in ultrasonic waves, and then reacted at 50°C for 24 hours, moved to an oven, and dried at 80°C for 10 hours, then, use the water alcohol The solution was washed, then dried at 100° C. for 10 hours, dried, and pulverized to make modified nano-inorganic powders for future use, and the reserve amount was slightly greater than the required amount.

[0030] Add 5.00 g of triethylene glycol dimetha...

Embodiment 2

[0032] Weigh 80.00 grams of fluorine-loaded zirconia nanotubes, 15.00 grams of barium strontium boron glass powder, and 5.00 grams of nano-hydroxyapatite, and mix the above three components uniformly by mechanical stirring to make a total weight It is 100.00 grams of nano-inorganic powder containing multiple components, and it is ready for use.

[0033] 2.00 grams of medical grade silane coupling agent KH-570 was hydrolyzed under the action of acetic acid, and 400 milliliters of hydroalcoholic solution was added. The premixed nano-inorganic powder containing multiple components is dispersed in ultrasonic waves, then reacted at 100°C for 2 hours, moved to an oven, and dried at 80°C for 2 hours, then, use the water alcohol The solution is washed, then dried at 80°C for 2 hours, and then heated to 100°C for 5 hours. After drying, it is pulverized to make a modified nano-inorganic powder, which is used for future use. The reserve amount is slightly larger than the required amount....

Embodiment 3

[0036] Weigh 45.00 grams of fluorine-loaded zirconia nanotubes, and, 25.00 grams of barium strontium boron glass powder, and, 10.00 grams of nano-hydroxyapatite, and, 5.00 grams of strontium glass powder, and, 5.00 grams of boron aluminum glass powder, and , 10.00 grams of commercially available barium-aluminum glass powder were uniformly mixed with the above multiple components by mechanical stirring to make a total weight of 100.00 grams of nano-inorganic powder containing multiple components for subsequent use.

[0037] 10.00 grams of medical grade silane coupling agent KH-570 was hydrolyzed under the action of acetic acid, and 200 milliliters of hydroalcoholic solution was added. The premixed nano-inorganic powder containing multiple components is dispersed in ultrasonic waves, then reacted at 100°C for 2 hours, moved to an oven, and dried at 80°C for 2 hours, then, use the water alcohol The solution was washed, then dried at 80°C for 12 hours, and then heated to 100°C for...

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Abstract

The invention relates to a drug release mechanism based fluorine-containing dental restorative material, belonging to the field of dental preparation. The invention aims at solving the problem that the current cavity-filling compound resin materials in the simple fluorine doped salt are fast in fluorine release, poor in interfacial compatibility and have no rigid support for the cavity-filling bodies. The material comprises the following components in percentage by weight: 20-85% of inorganic nanopowder subjected to surface modification by silane coupling agents, 8-70% of resin monomers such as bisphenol A-glycidyl methacrylate, 5-25% of diluents such as triethylene-glycol dimethacrylate, 0.25-2% of photoinitiators such as camphorquinone and 0.5-3% of coinitiators such as dimethylaminoethyl methacrylate. The technical scheme is characterized in that the inorganic nanopowder contains fluorine-carrying zirconia nanotubes which account for 10-80% of the inorganic nanopowder by weight. The fluorine-carrying zirconia nanotubes have the functions of resisting secondary caries by releasing fluorine and reinforcing structures.

Description

technical field [0001] The invention relates to a fluorine-containing tooth restorative material based on a drug slow-release mechanism, belonging to the field of A61K medical and dental preparations. Background technique [0002] In view of its comprehensive advantages, composite resin is a caries filling material that is gradually popular in clinical practice. [0003] Composite resins for caries filling can be roughly divided into two categories: single-paste composite resins and double-paste composite resins. Accompanied by a certain volume shrinkage, no matter what kind of composite resin is used for caries filling, micro-cracks are likely to occur on the edge of caries-filled fillings, which will cause edge micro-leakage and cause secondary caries. [0004] Many studies have shown that if the cavity filling material has the ability to release fluoride ions, the secondary caries at the edge of the cavity filling will be significantly reduced, because the released fluor...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K6/083A61K6/02
Inventor 李榕生李榕卿
Owner 江苏南田工机有限公司
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