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Granulating coated slow release product of cysteamine hydrochloride and preparation method thereof

A technology for making cysteamine hydrochloride and cysteamine hydrochloride, which is applied in the field of cysteamine hydrochloride granulation-coated sustained-release products and its preparation, to increase stability, not easily oxidize, and enhance slow-release suitable effect

Active Publication Date: 2011-06-22
上海邦成生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, cysteamine hydrochloride is very easy to oxidize and absorb moisture, which leads to the rapid oxidation of cysteamine hydrochloride during the granulation, coating process and product placement of the finished product, which affects the use effect of the product
At present, the technical process adopted by cysteamine hydrochloride products on the market is physical granulation and coating. Due to the relatively low ratio of sustained-release materials and coating, palatability and stability problems exist at the same time.

Method used

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  • Granulating coated slow release product of cysteamine hydrochloride and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] 1. Formula:

[0051] Cysteamine hydrochloride 50 kg;

[0052] 50 kg cornstarch

[0053] Vitamin C 1.5 kg;

[0054] 40 kg of glucose powder;

[0055] Stearic acid 10 kg;

[0056] 4.0 kg of 85wt% phosphoric acid;

[0057] All the above-mentioned raw materials can be purchased in the raw material market.

[0058] Second, the operation process steps are as follows:

[0059] (1) Melting of cysteamine hydrochloride: put cysteamine hydrochloride and vitamin C in a plastic container, heat in a boiling water bath until completely dissolved, and heat to 80°C.

[0060] (2) Add glucose powder and melt: when the temperature of the molten liquid reaches 80°C, add food-grade glucose powder, heat and stir until completely dissolved, and heat to 90°C.

[0061] (3) Maillard reaction: when the temperature of the molten liquid reaches 90°C, heat and stir in a boiling water bath to carry out the Maillard reaction, and the reaction time is 85 minutes.

[0062] (4) Cooling, adding 85w...

Embodiment 2

[0073] 1. Formula:

[0074] Cysteamine hydrochloride 52 kg;

[0075] 50 kg cornstarch

[0076] Vitamin C 1.25 kg;

[0077] Glucose 42 kg;

[0078] Stearic acid 8 kg;

[0079] 85wt% phosphoric acid 4.25 kg;

[0080] All the above-mentioned raw materials can be purchased in the raw material market.

[0081] Second, the operation process steps are as follows:

[0082] (1) Melting of cysteamine hydrochloride: put cysteamine hydrochloride and vitamin C in a plastic container, heat in a boiling water bath until completely dissolved, and heat to 85°C.

[0083] (2) Add glucose powder and melt: when the temperature of the molten liquid reaches 85°C, add food-grade glucose powder, heat and stir until completely dissolved, and heat to 95°C.

[0084] (3) Maillard reaction: when the temperature of the molten liquid reaches 95° C., heat and stir in a boiling water bath to carry out Maillard reaction, and the reaction time is 100 minutes.

[0085] (4) Cooling, add 85wt% phosphoric ac...

Embodiment 3

[0095] 1. Formula:

[0096] Cysteamine hydrochloride 54 kg;

[0097] 52kg cornstarch

[0098] Vitamin C 1.5 kg;

[0099] Glucose 45 kg;

[0100] Stearic acid 10 kg;

[0101] 5.5 kg of 85wt% phosphoric acid;

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Abstract

The invention discloses a granulating coated slow release product of cysteamine hydrochloride and a preparation method thereof. The product is obtained by taking cysteamine hydrochloride, corn starch, vitamin C, powdered glucose, stearic acid and 85wt percent phosphoric acid solution as raw materials through the processes of heating for dissolving, millard reaction, stabilization treatment, atomized granulation, hardening waterproof coating, enteric coating, drying, sieving and the like, wherein the content of the cysteamine hydrochloride in the product is more than or equal to 30.50 percent and the water content ranges from 0 percent to 8.0 percent. The method thoroughly eradicates the odor of the cysteamine hydrochloride, the product has the fragrance of bulked corn, and the glucose added in the millard reaction can conduct physical coverage and cause the cysteamine hydrochloride to be slowly released, thus increasing the palatability of products. The addition of glucose in full-price materials not only does not affect feed intake, but also can increase the feed intake. In the process of technological treatment and storage of the products, the content of cysteamine hydrochlorideis stable.

Description

technical field [0001] The invention relates to cysteamine hydrochloride, in particular to a cysteamine hydrochloride granulated and coated slow-release product and a preparation method thereof. Background technique [0002] Cysteamine hydrochloride can inhibit the secretion of somatostatin in animals, promote animal growth, increase feed-to-meat ratio and protein deposition rate. At present, cysteamine hydrochloride products mainly include powder and granular products. [0003] Because cysteamine hydrochloride itself has a strong odor and bitter taste, it has a great impact on animal feed intake. At the same time, cysteamine hydrochloride is very easy to oxidize and absorb moisture, which leads to the rapid oxidation of cysteamine hydrochloride during the granulation, coating process and product placement of the finished product, which affects the use effect of the product. At present, the technological process adopted by cysteamine hydrochloride products on the market i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K31/198A61K47/36A61K47/32A61P43/00
Inventor 陆克文李亮欧阳亮许云英
Owner 上海邦成生物工程有限公司
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