Skin care cosmetic containing liposome recombinant human growth hormone and preparation method thereof

A technology for human growth hormone and skin care, applied in skin care preparations, cosmetic preparations, cosmetics, etc., can solve the problem of decreased activity of recombinant human growth hormone, achieve the effect of increased encapsulation rate and long-term maintenance of activity

Inactive Publication Date: 2012-08-22
江西宇骏生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The recombinant human growth hormone in the technical solution recorded in the 03129040.X patent is not protected by liposomes. When the recombinant human growth hormone is used in cosmetics, the activity of the recombinant human growth hormone gradually decreases over time

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1, a kind of cosmetics containing liposome recombinant human growth hormone for skin care, wherein: mixed by the following raw materials in weight ratio: 1.80 parts of polyoxyethylene fatty alcohol ether, 0.75 parts of polysorbate fat 60, 7.30 parts Glyceryl monolaurate, 1.75 parts cetyl alcohol, 4.00 parts liquid paraffin, 6.95 parts glycerin, 0.20 parts sodium polyacrylate, 0.20 parts polyvinylpyrrolidone K30, 1.95 parts alpha-lipoic acid, 0.80 parts fragrance, 0.80 parts preservative, 71.40 parts of ionized water, 0.15 parts of liposomal human growth hormone.

Embodiment 2

[0021] Embodiment 2, a preparation method of cosmetics containing liposome recombinant human growth hormone for skin care, wherein: mixed with the raw materials in the following weight ratio: 1.80 parts of polyoxyethylene fatty alcohol ether, 0.75 part of polysorbate 60 , 7.30 parts of glyceryl monolaurate, 1.75 parts of cetyl alcohol, 4.00 parts of liquid paraffin, 6.95 parts of glycerin, 0.20 parts of sodium polyacrylate, 0.20 parts of polyvinylpyrrolidone K30, 1.95 parts of α-lipoic acid, 0.80 parts of fragrance, 0.80 parts Preservatives, 71.40 parts of ionized water, 0.15 parts of liposomal human growth hormone;

[0022] The preparation method of liposomal human growth hormone is as follows:

[0023] The weight ratio of the main raw materials is: 1 part of lecithin, 7 parts of absolute ethanol, 2 parts of trehalose, and 1 part of recombinant human growth hormone;

[0024] After dissolving 1 part of lecithin with 6 parts of absolute ethanol, add phosphate buffer to adjust ...

Embodiment 3

[0025] Embodiment 3, a kind of preparation method of cosmetics containing liposome recombinant human growth hormone for skin care, wherein: mixed by the raw materials of following weight ratio: 7.30 parts of glyceryl monolaurate, 1.75 parts of cetyl alcohol, 4.00 parts Liquid paraffin, 7.00 parts of glycerin, 0.20 parts of sodium polyacrylate, 0.20 parts of polyvinylpyrrolidone K30, 1.95 parts of α-lipoic acid, 0.80 parts of spices, 0.80 parts of preservatives, 71.40 parts of ionized water, 0.15 parts of liposomal human growth hormone;

[0026] The preparation method of liposomal human growth hormone is as follows:

[0027] The weight ratio of the main raw materials is: 1 part of lecithin, 7 parts of absolute ethanol, 2 parts of trehalose, 1 part of recombinant human growth hormone, 1.8 parts of polyoxyethylene fatty alcohol ether, 0.7 part of polysorbate 60;

[0028] After dissolving 1.8 parts of polyoxyethylene fatty alcohol ether, 0.7 part of polysorbate 60 and 1 part of le...

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PUM

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Abstract

The invention relates to a skin care cosmetic, in particular to a skin care cosmetic containing liposome recombinant human growth hormone. The cosmetic comprises polyoxyethylene fatty alcohol ether, polysorbate 60, monolaurin, hexadecanol, liquid paraffin, glycerol, sodium polyacrylate, polyvinylpyrrolidone K30, alpha-lipoic acid, perfume, preservative, ionized water, liposome human growth hormone. A surface active agent is introduced in the preparation process of liposome so that the encapsulation rate of the liposome human growth hormone is obviously improved. The invention can emulsify a product by a production technology of micro-emulsion to prepare millimicro-emulsion with the grain diameter of 100-200mm, thereby improving the local penetrability of the cosmetic on the skin, enabling an active substance to directly act on the horny layer to be uniformly distributed and showing more favorable effects of aging resistance, facial care, and the like and being more suitable for sensitive skin.

Description

technical field [0001] The invention relates to skin care cosmetics, in particular to skin care cosmetics containing liposome recombinant human growth hormone (rhGH) and a preparation method thereof. Background technique [0002] Recombinant human growth hormone is a drug approved by the national drug administration department, and it is recorded in the Chinese Pharmacopoeia on page 494 of the second part of the 2000 edition. [0003] Recombinant human growth hormone is a protein composed of 191 amino acid residues or 192 amino acid residues with -methionine at the N-terminal. It belongs to biologically active peptide analogues. Influenced by enzymes and other factors, it is directly used in cosmetics. Although it has a certain skin care effect, it is difficult to obtain better results. [0004] Experiments have proved that: Cosmetics containing recombinant human growth hormone: can promote skin epidermal hyperplasia and keratinization, enhance cell activity, accelerate the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/92A61K8/64A61Q19/00
Inventor 周隆才吴云江楼根福楼秀余梁华正
Owner 江西宇骏生物工程有限公司
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