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Fiber base protein molecularly imprinted polymer aquagel and preparation method thereof

A molecular imprinting and protein technology, used in fiber processing, textiles and papermaking, etc., can solve the problems of slow adsorption rate, low mechanical strength of gel, poor reusability, etc., and achieve high mechanical strength, good development prospects, and reusability. Good results

Inactive Publication Date: 2010-06-02
TIANJIN POLYTECHNIC UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In view of the deficiencies in the prior art, the technical problems to be solved by the present invention are problems such as low gel mechanical strength, slow adsorption rate and poor reusability.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1. Preparation of bovine serum albumin-blotted hydrogel by grafting acrylamide on PP non-woven fabric induced by radiation

[0027] Add bovine serum albumin, acrylamide and N,N'-methylenebisacrylamide to deionized water, stir to make it fully dissolved, and obtain a mass percentage concentration of bovine serum albumin of 0.1%, and a mass percentage concentration of acrylamide 8.9%, N, N'-methylenebisacrylamide mass percent concentration of 2.85% mixed solution A, solution A was poured into a test tube. Weigh a polypropylene fiber non-woven fabric with a mass of 1.78% of solution A, soak it into a test tube filled with mixed solution A, seal it and let it stand for 8 hours. The test tube containing the reaction mixture was irradiated with γ-rays at a radiation dose rate of 0.05kGy / h for 30 hours, and the polyacrylamide gel on the fiber surface was scraped off with tweezers to obtain protein-containing PP Fiber nonwovens grafted with polymer hydrogels. The prot...

Embodiment 2

[0028] Example 2. Preparation of bovine hemoglobin imprinted hydrogel by grafting acrylamide on PP non-woven fabric induced by radiation

[0029]Add bovine hemoglobin, acrylamide and N, N'-methylenebisacrylamide to deionized water, stir to make it fully dissolved, and obtain a mass percent concentration of bovine hemoglobin of 0.2%, and a mass percent concentration of acrylamide of 21.38%, The mass percent concentration of N,N'-methylenebisacrylamide is 0.22% mixed solution A, and the solution A is poured into a test tube. Weigh the polypropylene fiber non-woven fabric with 2% mass of the solution A, soak it into the test tube containing the mixed solution A, seal it and let it stand for 8 hours. The test tube containing the reaction mixture was irradiated with γ-rays at a radiation dose rate of 0.1kGy / h for 10 hours, and the polyacrylamide gel on the fiber surface was scraped off with tweezers to obtain protein-containing PP Fiber nonwovens grafted with polymer hydrogels. T...

Embodiment 3

[0030] Example 3. Preparation of ovalbumin imprinted hydrogel by grafting acrylamide on PP non-woven fabric induced by radiation

[0031] Add ovalbumin, acrylamide and N, N'-methylenebisacrylamide to deionized water, stir to make it fully dissolved, and obtain a mass percent concentration of ovalbumin of 1%, and a mass percent concentration of acrylamide of 10%, The mass percent concentration of N,N'-methylenebisacrylamide is 1% mixed solution A, and the solution A is poured into a test tube. Weigh the polypropylene fiber non-woven fabric with 2% mass of the solution A, soak it into the test tube containing the mixed solution A, seal it and let it stand for 8 hours. The test tube containing the reaction mixture was irradiated with γ-rays at a radiation dose rate of 0.05kGy / h for 10 hours, and the polyacrylamide gel on the fiber surface was scraped off with tweezers to obtain protein-containing PP Fiber nonwovens grafted with polymer hydrogels. The protein template was eluted...

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Abstract

The invention provides fiber base protein molecularly imprinted polymer aquagel and a preparation method thereof. The fiber base protein molecularly imprinted polymer aquagel comprises the following components by weight percent: 1.78-3.96 percent of polypropylene fiber (PP) non-woven cloth, 8.9-21.38 percent of acrylamide, 0.22-2.85 percent of N,N'-methylene-bis-acrylamide, 0.05-1 percent of protein and 71.26-89.06 percent of de-ionized water. The preparation method comprises the following steps of: adding the protein, the acrylamide and the N,N'- methylene-bis-acrylamide based on the component ratio into the de-ionized water to obtain mixed solution A, immersing the polypropylene fiber non-woven cloth into a test tube containing the mixed solution A; performing gamma-ray irradiation on the test tube with the reaction mixture under the condition of radiation dose rate of 0.05-1kGy / h, scraping polyacrylamide gel of fiber surface layers by using nippers and eluting protein template to obtain the fiber base protein molecularly imprinted polymer aquagel.

Description

technical field [0001] The invention relates to a non-woven fabric grafted hydrogel manufacturing method and molecular imprinting technology, in particular to the preparation of a protein fiber-based protein molecular imprinted polymer hydrogel, which belongs to the field of functional polymer materials. Background technique [0002] Protein molecularly imprinted polymers have become a current research hotspot due to their potential application in medical diagnosis, bioseparation and drug delivery [Gai Qingqing, Liu Qiuye, He Xiwen et al. Progress in Chemistry. 2008, 20(8): 957-968] . Due to the large size of protein molecules, easy denaturation, and very complex spatial structure, the research ideas and experimental methods of protein macromolecular imprinting are still in the exploratory stage. In recent years, more and more people use polymer hydrogels to study protein molecular imprinting. The exquisite structure of hydrogel can show repeated swelling changes under the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D06M14/28C08F220/56C08J9/26
Inventor 赵孔银魏俊富赵义平张金龙
Owner TIANJIN POLYTECHNIC UNIV
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