Inactivated vaccine for streptococcus suis and pasteurella multocida diseases and preparation method thereof

A Pasteurella and Streptococcus suis technology, applied in antibacterial drugs, pharmaceutical formulations, bacterial antigen components, etc., can solve problems such as waste, ineffective drug treatment, antibiotic drug residues, etc., and achieve the effect of easy operation and cost reduction

Active Publication Date: 2010-06-23
广东永顺生物制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing Pasteurella vaccine is a live bacterial vaccine, using live bacteria as the immunogen, there is a certain degree of shedding of the virus
In addition, due to the abuse of antibiotics, the emergence of drug-resistant strains leads to ineffective and wasteful drug treatment; the residue of antibiotic drugs makes meat animals face the problem of being unable to pass through when exporting

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] This product is selected from pathogenic Streptococcus equi subspecies zooepidemic strain C55138 of Langeri group C, Streptococcus suis type 2 HA9801 strain, Pasteurella capsule A group and capsule B group bacteria inoculated in a suitable medium for cultivation. The culture is inactivated by formaldehyde solution to remove residual toxins, and then concentrated and prepared by adding aluminum hydroxide gel. Various bacterial infections caused by group B bacteria. This includes several of the most important bacterial diseases that are currently prevalent. The strains used in the manufacture and inspection of this product are Streptococcus equi subsp. zooepidemicus strain C55138 of Langeri C group, Pasteurella multocida P71 strain of capsular group A and Pasteurella multocida C44-1 of capsular group B group ( C44-8) strains and other virulent strains can be used for efficacy inspection, all of which are identified, kept and supplied by the China Veterinary Drug Administ...

Embodiment 2

[0067] Example 2 Efficacy Research

[0068] With 20 healthy susceptible pigs, 2ml of the vaccine prepared in Example 1 was injected intramuscularly, containing 1 dose; after 21 days, each virulent strain was used for virulent challenge.

[0069] Streptococcus group C C55138 strain:

[0070] Select 5 immunized pigs, together with 5 control pigs with the same conditions, inject the lethal dose of virulent bacteria liquid of C55138 strain, and observe for 10 days. If more than 4 / 5 of the immunized pigs are protected and more than 4 / 5 of the control pigs die, they are qualified.

[0071] Streptococcus suis type 2 HA9801 strain:

[0072] Select 5 immunized pigs, together with 5 control pigs with the same conditions, to attack with a lethal dose of HA9801 virulent strain, and observe for 10 days. More than 4 / 5 of the control group died, and more than 4 / 5 of the immunized group were protected, which was judged as qualified.

[0073] Pasteurella strain P71:

[0074] Select 5 immuni...

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PUM

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Abstract

The invention provides an inactivated vaccine for streptococcus suis and pasteurella multocida diseases and a preparation method thereof, which can prevent streptococcus suis infection caused by a plurality of different sero-group streptococcus and infection caused by a plurality of different capsular serotype pasteurella multocida, achieves multiple preventions with one injection clinically, and is lowered in cost, free from the hidden hazard of virus dispersion, safe and reliable. The invention further provides a method for preparing the inactivated vaccine for streptococcus suis and pasteurella multocida diseases.

Description

technical field [0001] The invention relates to the field of veterinary biological products, in particular to an inactivated vaccine for streptococcus suis and pasteurellosis multocida. Background technique [0002] Streptococcus suis and pasteurellosis are the two most important bacterial infectious diseases of pigs in my country. [0003] Streptococcus suis is a multi-symptom pig disease caused by a variety of streptococcal infections. It mainly causes symptoms such as septicemia, meningitis, pleurisy, tissue abscess, and arthritis in pigs. The mortality rate is high and it is seriously harmful when it is popular Pig farming. [0004] Since the 1960s in China, streptococcal suis has occurred successively in Guangxi, Guangdong, Fujian, Hunan, Jiangxi, Anhui, Jiangsu, Sichuan and other places. loss. According to statistics, the main serotype is Langley C group, followed by Langley D group and E group. In recent years, cases of Group R have been found in Guangdong, Jiangs...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/116A61K39/102A61K39/09A61K39/39A61P31/04
Inventor 游启有林旭埜张毓金杨球郭沈涛以体强
Owner 广东永顺生物制药股份有限公司
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