Unlock instant, AI-driven research and patent intelligence for your innovation.

Glipizide long-acting slow-release preparation and preparation method thereof

A technology for glipizide and sustained-release preparations, applied in the field of glipizide long-acting sustained-release preparations and preparation thereof, can solve the problems of complicated preparation process, high cost, and high cost of osmotic pump controlled-release tablets, and achieves The effect of good absorption, simplified production process and cost reduction

Active Publication Date: 2012-09-26
SHANGHAI SUNTECH PHARMA +2
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the industrial production of this method, the preparation process of the osmotic pump controlled-release tablet is quite complicated, and the cost is relatively high.
The osmotic pump process needs to make a double-layer tablet with a drug chamber and an osmotic chamber, then coat it with a semi-permeable membrane polymer, use a laser to punch holes on one side of the drug chamber, and then coat, the whole process Both require specific manufacturing equipment, making the cost of the whole tablet higher

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Glipizide long-acting slow-release preparation and preparation method thereof
  • Glipizide long-acting slow-release preparation and preparation method thereof
  • Glipizide long-acting slow-release preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Formula composition and the amount of ingredients:

[0046] Glipizide tablet core: Glipizide: 10.0mg

[0047] Anhydrous lactose: 146.9mg

[0048] Skeleton material: Hypromellose (K4M): 33.3mg

[0049] Hypromellose (K100M): 6.7mg

[0050] Colloidal silicon dioxide: 1.1mg

[0051] Magnesium stearate: 2.0mg

[0052] Coating prescription: polyacrylic acid resin: 1.57mg

[0053] Talc powder: 1.57mg

[0054] Triethyl citrate: 0.16mg

[0055] Polyethylene glycol: 0.78mg

[0056] Average weight of tablets: 204.2mg, specification 10mg

Embodiment 2

[0058] Formula composition and the amount of ingredients:

[0059] Glipizide tablet core: Glipizide: 10.0mg

[0060] Anhydrous lactose: 96mg

[0061] Skeleton material: Hypromellose (K100LV): 75.8mg

[0062] Hypromellose (K100M): 15.1 mg

[0063] Colloidal silicon dioxide: 1.1mg

[0064] Magnesium stearate: 2.0mg

[0065] Coating prescription: polyacrylic acid resin: 1.57mg

[0066] Talc powder: 1.57mg

[0067] Triethyl citrate: 0.16mg

[0068] Polyethylene glycol: 0.78mg

[0069] Average weight of tablets: 204.1mg, specification 10mg

Embodiment 3

[0071] Formula composition and the amount of ingredients:

[0072]Glipizide tablet core: Glipizide: 10.0mg

[0073] Anhydrous lactose: 126.0mg

[0074] Skeleton material: Hypromellose (K100LV): 66.8mg

[0075] Hypromellose (K100M): 24.1 mg

[0076] Colloidal silicon dioxide: 1.1mg

[0077] Magnesium stearate: 2.0mg

[0078] Coating prescription: polyacrylic acid resin: 1.57mg

[0079] Talc powder: 1.57mg

[0080] Triethyl citrate: 0.16mg

[0081] Polyethylene glycol: 0.78mg

[0082] Average weight of tablets: 234.1mg, specification 10mg

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a glipizide long-acting slow-release preparation and a preparation method thereof. A slow-release tablet taking cellulose ethers or high molecular substances as a framework material is adopted, the cost of a slow-release tablet prepared by an osmotic pump technique is greatly lowered, the preparation process is simplified, a slow-release substrate achieves linear controllable release by the improvement of the raw materials and the control of the process, the stability of a medicine is good, the time lag of 2 hours is basically achieved by a filming process, and the medicine can be better absorbed in the gastrointestinal tract. The method is simple and convenient, has low cost and is suitable for industrialized production.

Description

technical field [0001] The invention relates to pharmaceutical preparations, in particular to a glipizide long-acting sustained-release preparation and a preparation method thereof. Background technique [0002] Glipizide (Glipizide), chemical name 1-cyclohexyl-3-(4-(2-(5-methylpyrazine-2-carboxamido) ethyl) benzenesulfonyl) urea, its molecular formula is C 21 h 27 N 5 o 4 S, the molecular weight is 445.54, the structural formula is as follows: [0003] [0004] Glipizide mainly promotes insulin secretion of pancreatic β cells, especially glucose-stimulated insulin secretion, and enhances the effect of insulin on target tissues, thereby effectively reducing blood sugar concentration and glycosylated hemoglobin; Hyperlipidemia, reduce triglyceride and cholesterol levels, increase the ratio of high-density lipoprotein cholesterol in total cholesterol, inhibit platelet aggregation and promote fibrinolysis, so it may have a certain preventive effect on vascular lesions. ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/22A61K31/64A61P3/10
Inventor 何平钱晓明
Owner SHANGHAI SUNTECH PHARMA