Oral solid drug composition of metformin hydrochloride repaglinide
A technology of metformin hydrochloride and its composition, which is applied in the field of oral solid pharmaceutical composition containing metformin hydrochloride repaglinide and its preparation, and can solve problems such as complex preparation process and difficulty in industrial production
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Embodiment 1
[0018]
[0019] Preparation:
[0020] Mix the prescribed amount of metformin hydrochloride, precrossed starch, and PVP evenly, add the ethanol solution of repaglinide, stir evenly, add an appropriate amount of purified water to make a soft material, and granulate with 16 mesh; ventilate and dry at 60°C until the water content is 2-3 %, 24 mesh granules, add croscarmellose sodium and magnesium stearate, mix evenly, press into tablets to make plain tablets, make OPADRY II 85G into a 15% aqueous solution, and coat the weight gain to 3 %, that is.
Embodiment 2
[0022]
[0023] Preparation:
[0024] Weigh the prescribed amount of starch, prepare it into 10% starch slurry, and set aside; mix the prescribed amount of metformin hydrochloride and calcium hydrogen phosphate evenly, add the ethanol solution of repaglinide, stir evenly, add starch slurry to make soft material, 16 mesh granules; ventilated and dried at 60°C until the water content is 2-3%, granulated with 24 meshes, added with sorbitol, polacrilin potassium, and magnesium stearate, mixed evenly, pressed into tablets to obtain plain tablets, and OPADRY II 85G was formulated into 15 % aqueous solution, coating weight increase to 3%, that is.
Embodiment 3
[0026]
[0027] Preparation:
[0028] Weigh the prescription amount of HPMC, prepare it into a 2% solution, and set aside; mix the prescription amount of metformin hydrochloride, mannitol, and PVP evenly, add the ethanol solution of repaglinide, after stirring evenly, add the HPMC solution to make a soft material, 16 mesh Granules; ventilated and dried at 60°C until the water content is 2-3%, granulate with 24 mesh, add sodium carboxymethyl starch and magnesium stearate, mix well, press into tablets to obtain plain tablets, and make OPADRY II 85G into a 15% aqueous solution , the weight of the coating is increased to 3%, that is to say.
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