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Calcium phosphate nano-structure hollow microsphere and preparation method thereof

A technology of hollow microspheres and nanostructures, applied in the direction of nanostructure manufacturing, nanotechnology, nanotechnology, etc., can solve the problems of high cost, complicated process, difficult mass production, etc., and achieve low cost, simple process, and clean energy consumption non-polluting effect

Inactive Publication Date: 2013-01-16
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In recent years, although methods for preparing calcium phosphate hollow microspheres have been reported from time to time, they are still few in general, and some methods have disadvantages such as complex process, high cost, and need for post-processing to remove residual templates or surfactants. , difficult to mass-produce

Method used

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  • Calcium phosphate nano-structure hollow microsphere and preparation method thereof
  • Calcium phosphate nano-structure hollow microsphere and preparation method thereof
  • Calcium phosphate nano-structure hollow microsphere and preparation method thereof

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Embodiment 1

[0033] 0.07g PEG-PLA (PEG molecular weight 5000, EO / L A=4), 10mL containing 0.04M NaH 2 PO 4 and 0.04M Na 2 HPO 4 Solution and 20mL deionized water were mixed at room temperature, stirred for 60min, the pH value was adjusted to 5 with 0.5M dilute hydrochloric acid, and then 10mL 0.08M Ca(CH 3 COO) 2 , to form a clear precursor solution, and then transfer this solution to a 70mL reaction kettle, microwave heating to 120°C, and hydrothermal reaction for 5min. After cooling, the reaction solution was centrifuged, washed three times with deionized water and once with absolute ethanol, and then dried in vacuum at 37°C for 24 hours. The analysis shows that the obtained product is a calcium phosphate nanostructure hollow microsphere with a particle size of 1-2 μm.

Embodiment 2

[0035] 0.14g PEG-PLA (PEG molecular weight 5000, EO / LA=4), 10mL containing 0.04MNaH 2 PO 4 and 0.04M Na 2 HPO 4 Solution and 20mL deionized water were mixed at room temperature, stirred for 60min, the pH value was adjusted to 5 with 0.5M dilute hydrochloric acid, and then 10mL 0.08M Ca(CH 3 COO) 2 , to form a clear precursor solution, and then transfer this solution to a 70mL reactor, microwave heating to 120°C, and hydrothermal reaction for 60min. After cooling, the reaction solution was centrifuged, washed three times with deionized water, washed once with absolute ethanol, and then vacuum-dried at 37° C. for 24 h. Analysis shows that the obtained product is calcium phosphate nanostructured hollow microspheres with a particle size of 1-2 μm.

Embodiment 3

[0037]0.07g PEG-PLA (PEG molecular weight 5000, EO / LA=4), 10mL containing 0.04MNaH 2 PO4 and 0.04M Na 2 HPO 4 Solution and 20mL deionized water were mixed at room temperature, stirred for 60min, the pH value was adjusted to 5 with 0.5M dilute hydrochloric acid, and then 10mL 0.08M Ca(CH 3 COO) 2 , to form a clear precursor solution, and then transfer this solution to a 70mL reactor, microwave heating to 120°C, and hydrothermal reaction for 30min. After cooling, the reaction solution was centrifuged, washed three times with deionized water and once with absolute ethanol, and then dried in vacuum at 37°C for 24 hours. The analysis shows that the obtained product is a calcium phosphate nanostructure hollow microsphere with a particle size of 1-2 μm.

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Abstract

The invention belongs to the field of nano biomaterials and relates to a calcium phosphate nano-structure hollow microsphere and a preparation method thereof. The calcium phosphate nano-structure hollow microsphere is prepared by the following steps: dissolving biocompatible polymer, soluble calcium salt and soluble phosphate in water to form a uniform precursor solution, and carrying out the microwave heating hydrothermal treatment on the solution. The prepared calcium phosphate nano-structure hollow microsphere comprises various chemical components of calcium phosphate and hydroxyapatite (Ca10(PO4)6(OH)2); a shell of the hollow microsphere is a porous structure formed by the assembly of nano calcium phosphate pieces with the thickness of 10-50nm; and the diameter of the hollow microsphere is 1-10 micro meters. The invention has the advantages of fast preparation, simple process and low cost, and the prepared nano-structure hollow microsphere has the advantages of favorable biocompatibility and the like, thereby having good application prospects in the field of biomedicine.

Description

technical field [0001] The invention belongs to the field of nanobiological materials, and in particular relates to calcium phosphate nanostructured hollow microspheres and a preparation method thereof. Background technique [0002] Calcium phosphate (hydroxyapatite) is an important inorganic component in human hard tissues. It is commonly found in bones, teeth and other parts. It has good biocompatibility, osteoconductivity and osseointegration ability, and safe and non-toxic. Common calcium phosphate micromorphologies include nanorods, nanoneedles, nanosheets / plates, and amorphous nanoparticles. The performance of calcium phosphate depends largely on its phase, structure, morphology and crystallinity and other factors. Among the various morphologies, calcium phosphate nanostructured hollow microspheres have broad application prospects in the field of biomedicine due to their high specific surface area and high loading capacity of organic molecules. [0003] The preparat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01B25/32B82B1/00B82B3/00
Inventor 朱英杰王可伟段友容王琪
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI