High-efficiency water-solubility toltrazuril solution and preparation method thereof

A toltrazuril and water-soluble technology, applied in the field of water-soluble toltrazuril solutions and preparation methods, can solve the problem of accelerating the elimination speed of the triazinone drug market, the inability of sick animals to drink drugs, and the development of drug resistance in sick animals and other problems, to achieve the effect of reducing adverse pharmacological effects, improving bioavailability, and solving the problem of dilution and precipitation
CN101766564AInactive Publication Date: 2010-07-07QINGDAO ZHONGREN PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
QINGDAO ZHONGREN PHARMA
Publication Date
2010-07-07
Estimated Expiration
Not applicable · inactive patent
Patent Text Reader

Abstract

The invention relates to a high-efficiency water-solubility toltrazuril solution which comprises the following components in percentage by weight: 2-6 percent of toltrazuril, 2-10 percent of inclusion agent, 1 percent of antistatic agent, 7-17 percent of composite emulsifying agent, 1-3 percent of pH regulator, 1 percent of antioxidant, 35-70 percent of composite organic solvent and the balance of purified water. In the invention, an advanced microemulsion preparation process is adopted, and the water insoluble toltrazuril is prepared into a water-insoluble microemulsion solution which can be mixed with water in any proportion, therefore, the dilution and precipitation problems are effectively solved, the bioavailability of the product is improved, and the medicine consumption is reduced; and compared with the prior art, the invention reduces the consumption of the organic solvent and the harmful pharmacological action, saves the cost and improves the security.
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Description

technical field

[0001] The invention relates to a medicine and a preparation method thereof, in particular to a water-soluble toltrazuril solution prepared by using medicine inclusion technology and microemulsion preparation technology and a preparation method thereof. Background technique

[0002] Chicken coccidiosis is an acute epidemic parasitic disease caused by one or more unicellular parasites of the genus Eimer. my country has listed it as a second-class animal disease. Among various chicken diseases, the incidence of coccidiosis is the highest, accounting for about 1 / 6-1 / 5, especially the chicks within 3 months of age are the most susceptible to infection, and the mortality rate can reach 70%, and the recovered chicks are often several It is not easy to recover health within a month. Most adult chickens are also carriers. Other poultry such as ducks, turkeys, pigeons, crane quails, etc. can be infected, which seriously affects the development of my country's breed...

Claims

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