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Pharmaceutical composite for osteoporosis treatment and preparation method thereof

An osteoporosis and composition technology, applied in the field of pharmaceutical compositions, can solve the problems of poor improvement, easy to produce gastrointestinal reactions and the like

Active Publication Date: 2010-07-07
涂雪莲
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, calcium is the basic drug for the treatment of osteoporosis, but in many cases, simple calcium can not improve symptoms such as "pain" and "spasm"; bone resorption inhibitors and bone formation accelerators are easy to treat. Side effects such as gastrointestinal reactions

Method used

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  • Pharmaceutical composite for osteoporosis treatment and preparation method thereof
  • Pharmaceutical composite for osteoporosis treatment and preparation method thereof
  • Pharmaceutical composite for osteoporosis treatment and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0084] The preparation of embodiment 1-dropping pill

[0085] The pharmaceutical composition for treating osteoporosis of the present invention is characterized in that it is mainly made of the following raw materials by weight:

[0086] Paeoniae Alba 5 Licorice 5

[0087] Papaya 5 Chuanxiong 3

[0088] Calcium source 0.5 Vitamin D 3 1.25.

[0089]The specific preparation method is: take white peony root, licorice, papaya, and Chuanxiong, add water to decoct twice, filter, concentrate the filtrate to an appropriate amount, let it cool, add ethanol to make the solution alcohol content 75%, let it stand for 24 hours, filter , recover ethanol, concentrate to a thick extract; take an appropriate amount of polyethylene glycol 6000 (PEG-6000) into a container, heat to 90 ° C ~ 95 ° C, after it is completely melted, add calcium carbonate, vitamin D 3 And above-mentioned thick extract, after dispersing evenly, take liquid paraffin as cooling agent and drop into pill, take out ...

Embodiment 2

[0090] Example 2 - Preparation of Tablets

[0091] The pharmaceutical composition for treating osteoporosis of the present invention is characterized in that it is mainly made of the following raw materials by weight:

[0092] Paeoniae Alba 100 Licorice 30

[0093] Papaya 30 Chuanxiong 20

[0094] Calcium Source 3 Vitamin D 3 10.

[0095] The specific preparation method is: take white peony root, licorice, papaya, and Chuanxiong, add water to decoct twice, filter, concentrate the filtrate to an appropriate amount, let it cool, add ethanol to make the solution alcohol content 75%, let it stand for 24 hours, filter , recovery of ethanol, concentrated to a thick extract. Vacuum dried into a dry paste, then pulverized into a dry paste powder or directly spray-dried to obtain a dry paste powder; take the obtained dry paste powder, add appropriate amount of starch, powdered sugar and mannitol, and calcium hydrogen phosphate, vitamin D 3 , mixed evenly, made into granules, d...

Embodiment 3

[0096] Example 3 - Preparation of Tablets

[0097] The pharmaceutical composition for treating osteoporosis of the present invention is characterized in that it is mainly made of the following raw materials by weight:

[0098] Paeoniae Alba 9 Licorice 9

[0099] Papaya 25 Chuanxiong 10

[0100] Calcium Source 2.5 Vitamin D 3 3.75.

[0101] The specific preparation method is: take white peony root, licorice, papaya, and Chuanxiong, add water to decoct twice, filter, concentrate the filtrate to an appropriate amount, let it cool, add ethanol to make the solution alcohol content 75%, let it stand for 24 hours, filter , recovery of ethanol, concentrated to a thick extract. Vacuum dried into a dry cream, then pulverized into a dry cream powder or directly spray-dried to obtain a dry cream powder; take the obtained dry cream powder, add appropriate amount of starch, sugar powder and mannitol, and calcium citrate, calcium malate, vitamin D 3 , mixed evenly, made into granule...

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PUM

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Abstract

The invention discloses a pharmaceutical composite for osteoporosis treatment, mainly comprising the following indigents of 5-100 parts of radix paeoniae alba, 5-30 parts of radix glycyrrhizae, 5-30 parts of papaya, 3-20 parts of rhizome of Sichuan lovage, 0.5-6 parts of calcium, 31.25-10 parts of vitamin D by weight. The invention aims to overcome the deficiencies of the prior art, provides a medical composite that can effectively treat osteoporosis, improve pain and spasmus and be difficult to give rise to side effect in gastrointestinal tract. In addition, the invention aims to provide a method for preparing the medical composite.

Description

technical field [0001] The present invention relates to a pharmaceutical composition; in particular to a pharmaceutical composition for treating osteoporosis; the present invention also relates to a method for preparing the pharmaceutical composition. Background technique [0002] Osteoporosis (OP) is a systemic skeletal disease characterized by decreased bone mass and degeneration of bone microstructure, resulting in increased bone fragility and susceptibility to fractures. Its pathogenesis is currently believed to be related to hormone regulation and nutritional status. , physical factors, immune function and genetics are all related. Osteoporosis can be divided into three categories, the most important of which is primary osteoporosis, which is a physiological degenerative disease that inevitably occurs with age. The clinical manifestations and signs of primary osteoporosis are mainly pain, followed by body shortening, kyphosis, fracture and respiratory system disorder. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/732A61K9/06A61K9/16A61K9/20A61K9/48A61P19/10A61K31/593A61K33/10A61K35/56A61K31/19A61K31/191A61K35/618
Inventor 涂雪莲
Owner 涂雪莲
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