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Artificial joint having slow-release function of rare earth element cerium and preparation method thereof

A technology for artificial joints and rare earth elements, which is used in chemical instruments and methods, medical science, inorganic chemistry, etc.

Active Publication Date: 2010-07-07
NANTONG MINGXIN CHEM +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Technical problem: The purpose of this invention is to address the above-mentioned shortcomings of artificial joint materials, and propose an artificial joint with a slow-release function of rare earth element cerium, and can significantly improve the ability of the artificial joint surface to induce osteogenesis at the initial stage of implantation and its preparation method

Method used

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  • Artificial joint having slow-release function of rare earth element cerium and preparation method thereof
  • Artificial joint having slow-release function of rare earth element cerium and preparation method thereof
  • Artificial joint having slow-release function of rare earth element cerium and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] (1) First choose pure titanium to process the artificial joint;

[0027] (2) Hydrothermal treatment of the artificial joint surface: the artificial joint is ground and polished, then ultrasonically cleaned with acetone, 70% alcohol, and distilled water, and the hydrothermal reaction is carried out with a sodium hydroxide aqueous solution with a concentration of 10mol / L, and the working temperature is 120 degrees Celsius. The time is 6 hours, and a sodium titanate bioactive coating with a microporous structure is obtained on the surface of the artificial joint.

[0028] (3) Cerium doping treatment by dipping method: The artificial joint prepared above covered with microporous sodium titanate bioactive layer was immersed in soluble cerium salt (NH 4 ) 2 Ce(NO 3 ) 6 The rare earth element cerium was doped into the aqueous solution by ion exchange, (NH 4 ) 2 Ce(NO 3 ) 6 The concentration of the aqueous solution is 0.05mol L -1 , the liquid level of the solution shou...

Embodiment 2

[0032] (1) First choose Ti6Al4V alloy to process the artificial joint;

[0033](2) Hydrothermal treatment of the artificial joint surface: the artificial joint is ground and polished, then ultrasonically cleaned with acetone, 70% alcohol, and distilled water, and the hydrothermal reaction is carried out with a sodium hydroxide aqueous solution with a concentration of 10mol / L, and the working temperature is 120 degrees Celsius. The time is 6 hours, and a sodium titanate bioactive coating with a microporous structure is obtained on the surface of the artificial joint.

[0034] (3) Cerium doping treatment by dipping method: The artificial joint prepared above covered with microporous sodium titanate bioactive layer was immersed in soluble cerium salt Ce(NO 3 ) 4 The rare earth element cerium, Ce(NO 3 ) 4 The concentration of the aqueous solution is 0.05mol L -1 , the liquid level of the solution should be submerged over the artificial joint, and the soaking time should be no ...

Embodiment 3

[0038] (1) First choose pure titanium to process the artificial joint;

[0039] (2) Hydrothermal treatment of the artificial joint surface: the artificial joint is ground and polished, then ultrasonically cleaned with acetone, 70% alcohol, and distilled water, and the hydrothermal reaction is carried out with a sodium hydroxide aqueous solution with a concentration of 10mol / L, and the working temperature is 150 degrees Celsius. The time is 72 hours, and a sodium titanate bioactive coating with microporous structure is obtained on the surface of the artificial joint, and its SEM photos and XRD spectra are shown in figure 1 and figure 2 .

[0040] (3) Cerium doping treatment by dipping method: The artificial joint prepared above covered with microporous sodium titanate bioactive layer was immersed in soluble cerium salt (NH 4 ) 2 Ce(NO 3 ) 6 The rare earth element cerium was doped into the aqueous solution by ion exchange, (NH 4 ) 2 Ce(NO 3 ) 6 The concentration of the...

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Abstract

The invention discloses an artificial joint having a slow-release function of a rare earth element cerium and a preparation method thereof. The artificial joint consists of a pure titanium or titanium alloy artificial joint matrix and a microporous sodium titanate biological activity layer loaded with the rare earth element cerium and bone morphogenetic protein (BMP). The sodium titanate biological activity layer with a microporous structure is combined with the surface of a metal matrix and is formed by alternately stacking sodium titanate microporous structures generated by a hydrothermal reaction performed between the surface of the titanium or the titanium alloy matrix and solution of sodium hydroxide, the cerium and sodium perform cation interchange and are doped into a coating, and the BMP is compounded into the microporous structure through centrifugal force and under the action of a capillary tube. The preparation method comprises the following steps of: firstly, selecting the pure titanium or the titanium alloy to process the artificial joint well; secondly, forming a sodium titanate layer with the microporous structure on the surface of the artificial joint by adopting an alkali liquor hydrothermal synthesis technique; thirdly, doping the rare earth element cerium into the microporous sodium titanate layer through solution impregnation ion exchange; and finally, loading the bone morphogenetic protein into the cerium-doped microporous sodium titanate layer by adopting a centrifugal load technique.

Description

technical field [0001] The present invention relates to an artificial joint with slow-release function of rare earth element cerium and its preparation method, in particular to a microporous sodium titanate bioactive coating obtained by selecting pure titanium or titanium alloy as a substrate and adopting lye hydrothermal synthesis technology The invention relates to an artificial joint loaded with bone morphogenetic protein through solution impregnation ion exchange doped with cerium and using a centrifugal loading technique and a preparation method thereof, belonging to the technical field of artificial joint materials. Background technique [0002] At present, the number of cases of artificial joint implanted into the human body can reach 1.2 million cases per year, and it is one of the implant materials with the largest demand in orthopedics at home and abroad. The commonly used artificial joints are metal materials. Because they are biologically inert materials, they ca...

Claims

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Application Information

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IPC IPC(8): A61L27/30A61L27/06A61L27/56A61L27/54C01G23/00
Inventor 储成林董寅生
Owner NANTONG MINGXIN CHEM
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