Artificial joint having slow-release function of rare earth element cerium and preparation method thereof

A technology of artificial joints and rare earth elements, applied in chemical instruments and methods, medical science, inorganic chemistry, etc.

Active Publication Date: 2012-10-24
NANTONG MINGXIN CHEM +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Technical problem: The purpose of this invention is to address the above-mentioned shortcomings of artificial joint materials, and propose an artificial joint with a slow-release function of rare earth element cerium, and can significantly improve the ability of the artificial joint surface to induce osteogenesis at the initial stage of implantation and its preparation method

Method used

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  • Artificial joint having slow-release function of rare earth element cerium and preparation method thereof
  • Artificial joint having slow-release function of rare earth element cerium and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] (1) First select pure titanium to process the artificial joint;

[0027] (2) Hydrothermal treatment of the artificial joint surface: the artificial joint is polished, then ultrasonically cleaned with acetone, 70% alcohol, and distilled water. A sodium hydroxide aqueous solution with a concentration of 10mol / L is used for hydrothermal reaction. The working temperature is 120 degrees Celsius. The time is 6 hours to obtain a bioactive coating of sodium titanate with a microporous structure on the surface of the artificial joint.

[0028] (3) The dipping method cerium doping treatment: the artificial joint prepared above, the surface of which is covered with a microporous sodium titanate bioactive layer, is immersed in a soluble cerium salt (NH 4 ) 2 Ce(NO 3 ) 6 Rare earth element cerium, (NH 4 ) 2 Ce(NO 3 ) 6 The concentration of the aqueous solution is 0.05mol·L -1 , The surface of the solution should be submerged in the artificial joint, and the immersion time should not be le...

Embodiment 2

[0032] (1) First select Ti6Al4V alloy to process the artificial joint;

[0033] (2) Hydrothermal treatment of the artificial joint surface: the artificial joint is polished, then ultrasonically cleaned with acetone, 70% alcohol, and distilled water. A sodium hydroxide aqueous solution with a concentration of 10mol / L is used for hydrothermal reaction. The working temperature is 120 degrees Celsius. The time is 6 hours to obtain a bioactive coating of sodium titanate with a microporous structure on the surface of the artificial joint.

[0034] (3) Dipping cerium-doped treatment: the artificial joint prepared above, covered with a microporous sodium titanate bioactive layer, is immersed in a soluble cerium salt Ce(NO 3 ) 4 Rare earth element cerium, Ce(NO 3 ) 4 The concentration of the aqueous solution is 0.05mol·L -1 , The surface of the solution should be submerged in the artificial joint, and the immersion time should be no less than 24 hours, and then washed several times with deio...

Embodiment 3

[0038] (1) First select pure titanium to process the artificial joint;

[0039] (2) Hydrothermal treatment of the artificial joint surface: the artificial joint is polished, then ultrasonically cleaned with acetone, 70% alcohol, and distilled water, and a sodium hydroxide aqueous solution with a concentration of 10mol / L is used for hydrothermal reaction. The working temperature is 150 degrees Celsius. It took 72 hours to obtain a bioactive coating of sodium titanate with a microporous structure on the surface of the artificial joint. The SEM and XRD spectra are shown respectively figure 1 with figure 2 .

[0040] (3) The dipping method cerium doping treatment: the artificial joint prepared above, the surface of which is covered with a microporous sodium titanate bioactive layer, is immersed in a soluble cerium salt (NH 4 ) 2 Ce(NO 3 ) 6 Rare earth element cerium, (NH 4 ) 2 Ce(NO 3 ) 6 The concentration of the aqueous solution is 0.05mol·L -1 , The surface of the solution should be...

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Abstract

The invention discloses an artificial joint having a slow-release function of a rare earth element cerium and a preparation method thereof. The artificial joint consists of a pure titanium or titanium alloy artificial joint matrix and a microporous sodium titanate biological activity layer loaded with the rare earth element cerium and bone morphogenetic protein (BMP). The sodium titanate biological activity layer with a microporous structure is combined with the surface of a metal matrix and is formed by alternately stacking sodium titanate microporous structures generated by a hydrothermal reaction performed between the surface of the titanium or the titanium alloy matrix and solution of sodium hydroxide, the cerium and sodium perform cation interchange and are doped into a coating, and the BMP is compounded into the microporous structure through centrifugal force and under the action of a capillary tube. The preparation method comprises the following steps of: firstly, selecting thepure titanium or the titanium alloy to process the artificial joint well; secondly, forming a sodium titanate layer with the microporous structure on the surface of the artificial joint by adopting an alkali liquor hydrothermal synthesis technique; thirdly, doping the rare earth element cerium into the microporous sodium titanate layer through solution impregnation ion exchange; and finally, loading the bone morphogenetic protein into the cerium-doped microporous sodium titanate layer by adopting a centrifugal load technique.

Description

Technical field [0001] The invention relates to a rare earth element cerium slow-release functional artificial joint and a preparation method thereof, in particular to a processing matrix selected from pure titanium or titanium alloy, and a microporous sodium titanate bioactive coating obtained by adopting alkaline solution hydrothermal synthesis technology , An artificial joint that is doped with cerium through solution immersion ion exchange, and uses centrifugal loading technology to load bone morphogenetic protein and a preparation method thereof, belonging to the technical field of artificial joint materials. Background technique [0002] At present, the number of artificial joints implanted into the human body can reach 1.2 million cases every year, which is one of the implant materials with the largest demand for orthopedics at home and abroad. The commonly used artificial joints are metal materials. Because they are biologically inert materials, they cannot form a firm ph...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/30A61L27/06A61L27/56A61L27/54C01G23/00
Inventor 储成林董寅生
Owner NANTONG MINGXIN CHEM
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