SiO2 nano-particle taking positive electrical polyelectrolyte as template and doped with negative electricity dye and preparation method thereof

一种聚电解质、纳米粒子的技术，应用在用于材料和表面科学的纳米技术、纳米技术、纳米技术等方向，能够解决染料不具有保护作用等问题

Active Publication Date: 2010-07-07
WUXI ZODOLABS BIOTECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But at this time SiO 2 Particles only act as carriers and do not protect the dye

Method used

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  • SiO2 nano-particle taking positive electrical polyelectrolyte as template and doped with negative electricity dye and preparation method thereof
  • SiO2 nano-particle taking positive electrical polyelectrolyte as template and doped with negative electricity dye and preparation method thereof
  • SiO2 nano-particle taking positive electrical polyelectrolyte as template and doped with negative electricity dye and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] Add 0.5ml of alcohol / water = 8 alcohol-water mixture, 4ml of ethanol, 100μl of PDADMAC (molecular weight 100,000 to 200,000 Da) aqueous solution with a concentration of 10mg / ml into a 20ml glass bottle, magnetic stirring (speed is 500rpm) Add 400 μl HPTS aqueous solution (1 mg / ml) to the bottom, stir for 20 minutes to obtain a complex solution of polyelectrolyte and fluorescent dye; add 8.4 ml ethanol, 815 μl water, 0.1 ml ammonia water to a 20 ml glass bottle, control the magnetic stirring speed to 200 rpm, add 300 μl TEOS Start counting and start timing. After 25 minutes of reaction, take 1ml of the complex solution of polyelectrolyte and fluorescent dye and quickly add it to the In the system, after mixing, the magnetic stirring speed was controlled to be 50 rpm, and the reaction was continued for 24 hours. Prepared HPTS-doped spherical SiO 2 The uniformity of nanoparticles is good, and the average particle size is 50±5nm.

[0071] figure 1 The SiO doped with ne...

Embodiment 2

[0073] Add 2.3ml of alcohol / water = 8 alcohol-water mixture, 2.4ml of ethanol, 100μl of PDADMAC (molecular weight of 100,000 to 200,000 Da) aqueous solution with a concentration of 10mg / ml into a 20ml glass bottle, magnetic stirring (speed of 500rpm) ), add 200 μl of HPTS aqueous solution (1 mg / ml), and stir for 20 minutes to obtain a complex solution of polyelectrolyte and fluorescent dye; add 8.4 ml of ethanol, 815 μl of water, and 0.1 ml of ammonia into a 20 ml glass bottle, and control the magnetic stirring speed to be 200 rpm, Add 300 μl TEOS to start counting and start timing. After 25 minutes of reaction, take 1 ml of the complex solution of polyelectrolyte and fluorescent dye and quickly add it to the solution. In the system, after mixing, the magnetic stirring speed was controlled to be 50 rpm, and the reaction was continued for 24 hours. Prepared HPTS-doped spherical SiO 2 The uniformity of nanoparticles is good, and the average particle size is 50±5nm.

Embodiment 3

[0075] Add 3.2ml of alcohol / water=8 alcohol-water mixture, 1.6ml of ethanol, and 100μl of 10mg / ml PDADMAC (molecular weight 100,000 to 200,000 Da) aqueous solution into a 20ml glass bottle, stir magnetically (speed at 500rpm) ), add 100 μl of HPTS aqueous solution (1 mg / ml) and stir for 20 minutes to obtain a complex solution of polyelectrolyte and fluorescent dye; add 8.4 ml of ethanol, 815 μl of water and 0.1 ml of ammonia to a 20 ml glass bottle, and control the magnetic stirring speed to be 200 rpm , adding 300 μl TEOS to start timing, after 25 minutes, quickly adding 1 ml of the complex solution of polyelectrolyte and fluorescent dye, mixing well, stirring at 50 rpm, and continuing to react for 24 hours.

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Abstract

Disclosed is an SiO2 nano-particle taking a positive electrical polyelectrolyte as a template and doped with a negative electricity dye, comprising a nuclear shell structure, a kernel comprises a polyelectrolyte cluster with positive electricity, and is doped with the fluorescent dye with negative electricity and SiO2, as well as a selectable additive with negative electricity, and a shell is composed of the SiO2, wherein, the sum of negative charges of the additive and the fluorescent dye is less than the number of positive charges of the polyelectrolyte cluster. A preparation method of the SiO2 nano-particle comprises steps of: composite solution preparation of the polyelectrolyte and the fluorescent dye; formation of the SiO2 nano-particle by hydrolysis and condensation of an organic silicon source; and organic silicon source coating. The invention can be widely applied to the doping of various fluorescent dyes with negative electricity groups in silicon dioxide, and can realize simultaneous doping of a plurality of dyes and control of dye doping amount and particle sizes and appearances of products, the prepared SiO2 nano-particle is spherical, the particle sizes are uniform, the surface functionalization is easy, and the formed colloid has good stability, so as to provide more options for biomedicine, theoretical research and the like.

Description

technical field [0001] The invention belongs to the technical field of luminescent nanomaterials, and particularly relates to SiO doped with negatively charged dyes using a positively charged polyelectrolyte as a template 2 Nanoparticles and methods of making the same. Background technique [0002] Dye-doped silica nanoparticles have a wide range of applications in the fields of biology, medicine, and theoretical studies of photophysical chemistry. Doping fluorescent dyes into silica improves many of its properties: dyes immobilized on SiO 2 In the medium, it can be isolated from solvents, oxygen, etc., to improve the dispersibility and photostability of dyes (Nano Letter 2005, 15, 113-117); it can be adjusted by adjusting SiO 2 Particle structure to change the dye microenvironment and improve the luminous efficiency and lifetime of the dye (Chem. Mater., 2008, 20, 2677-2684); SiO 2 Non-toxic, chemically inert, easy to surface functionalization, can expand the application...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/06C09K11/02
CPCC01P2004/34C01P2004/84C01P2004/64C01P2004/03C01P2004/04C01B33/18C01P2004/52C01P2004/51C09C1/30B82Y30/00C09K11/02C09K11/06C09K2211/1096
Inventor 杨文胜梁经纶李军
Owner WUXI ZODOLABS BIOTECH
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