Acidic buffer gel preparation for vaginas and preparation method and application thereof

Abstract

The invention discloses an acidic buffer gel preparation for vaginas, which takes polycarbophil and carbomer as acid agents, sodium salts of methyl hydroxybenzoate, hydroxyphenyl ethylester and propyl hydroxybenzoate as alkaline agents, and water and glycerol as solvents to form a ph buffer system with buffering capacity. The invention also discloses a preparation method of the preparation. The preparation process does not need strong acid or strong alkali to adjust the pH value, i.e., the ph value of an intermediate does not need to be frequently detected, so that the pH value of the prepared acidic gel preparation is accurately between 3. 5 and 3.1, and is very close to the lower limit of the pH value of the physiological vagina, and one-time use can maintain the effect for not less than 3 days.

Description

technical field [0001] The invention relates to a gel preparation for vagina, in particular to an acidic buffer gel preparation for vagina and its preparation method and application. Background technique [0002] In women of childbearing age, under the action of estrogen, the vaginal mucosa periodically sheds glycogen, and the normal flora decomposes these glycogen to produce acidic components such as lactic acid, making the environment in the vaginal canal acidic (pH 3.5-4.5). The acidic environment of the vagina is conducive to maintaining the status of dominant flora such as Lactobacillus, and can inhibit the growth of various pathogenic microorganisms. And when the vaginal microecological flora is in a state of imbalance, the significant increase of some endogenous flora or conditional pathogenic microorganisms and other anaerobic flora, when a certain type of flora (or trichomonas, mycoplasma) increases When it takes the dominant position, the clinical symptoms of vagi...

AI Technical Summary

Problems solved by technology

There are mainly the following problems: 1) Lactic acid is a small molecular organic acid, completely water-soluble, has no buffering capacity, and the pH is too low, which may be irritating

[0009] In addition, the gel has a certain viscosity. For gel products that need to control the pH value, it is usually necessary to adjust the pH value of the mixed material in the batching tank on the production line. It is difficult to mix the acid-base regulator evenly, and the pH value needs to be tested on site. It is often necessary to repeatedly adjust back and forth with sodium hydroxide solution and hydrochloric acid solution to obtain the set pH value. As a result, excessive unnecessary salt and solvent are brought into the The product varies greatly from batch to batch

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