Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method of Pranlukast intermediate

An intermediate and reaction time technology, applied in the field of pranlukast intermediates, can solve the problems of harsh reaction conditions and difficulty in industrial production, achieve mild reaction conditions, low production costs, and avoid unsafe or toxic reagents the effect of using

Inactive Publication Date: 2010-07-21
ZHEJIANG UNIV
View PDF3 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In this route, dangerous reagents such as n-butyllithium are used, and the reaction conditions are relatively harsh. It needs to be carried out at -78°C, and industrial production is difficult to achieve.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of Pranlukast intermediate
  • Preparation method of Pranlukast intermediate
  • Preparation method of Pranlukast intermediate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1: Preparation of ethyl 2-formate-6-bromo-8-nitro-4-oxo-4H-1-benzofuran

[0030] Add 200ml of absolute ethanol to a 500ml flask, weigh 4.8g of sodium, and add sodium to the ethanol. After the metal sodium reacted completely, heat up to reflux, add 20ml of diethyl oxalate, 10g (38.6mmol) of 5-bromo-2-hydroxy-3-nitroacetophenone, heat up to 75°C and reflux. After 40 minutes, pour the reaction system into 240ml of 2N hydrochloric acid and stir for one hour. A large amount of khaki flocculent precipitates are produced. After filtering, add the solid to 120ml of ethanol system, add about 6ml of concentrated hydrochloric acid, heat up to reflux, and stir for reaction. After about 60 minutes, it was cooled down to room temperature and filtered to obtain 10.35 g (30.3 mmol) of the target product. Yield 78.6%, Mp: 140-142°C. MS(m / z): 342.1(M+1), 364.1(M+23); 1 HNMR (CDCl 3 -d 1): δ8.58 (d, 1H), 8.48 (d, 1H), 7.21 (s, 1H), 4.47-4.51 (m, 2H), 1.44-1.47 (t, 3H).

Embodiment 2

[0031] Example 2: Preparation of 2-formamide-6-bromo-8-nitro-4-oxo-4H-benzofuran

[0032] Add the 6-bromo-8-nitro-4-oxo-4H-1-benzofuran-2-carboxylic acid ethyl ester obtained in the previous step reaction into 225ml of methanol, and pass through the ammonia gas by bubbling at room temperature , after reacting for 1.5h, the system was evaporated to dryness under reduced pressure to obtain a yellow solid, which was added to 150ml of concentrated hydrochloric acid, heated to 30-40°C and stirred for 2h, then diluted with 1000ml of ice water, filtered and the obtained filter cake was used Add it into 10% aqueous sodium bicarbonate solution and stir for 4-5 hours, filter and dry to obtain 6.44 g (0.021 mol) of the product, with a yield of 68.0%. Mp: 255-258°C; MS (m / z): 312.7 (M+1); 1 HNMR (DMSO-d 6 ): δ8.75(d, 1H), 8.42(d, 1H), 8.30(s, 1H), 8.00(s, 1H), 6.99(s, 1H).

Embodiment 3

[0033] Example 3: Preparation of 2-cyano-6-bromo-8-nitro-4-oxo-4H-1-benzopyran

[0034] Add POCl dropwise to 115ml DMF 3 9ml, the temperature is controlled at about 0°C, after the dropwise addition, stir and react at room temperature for 30min, dissolve the amide compound obtained above with 30mlDMF, add it to the reaction system, react at room temperature for 3h, and then slowly add the reaction system dropwise to 500ml ice In the water, solids were precipitated, filtered, the obtained product was added to 100ml ethyl acetate solution to dissolve the crude product, and 10% aqueous sodium bicarbonate solution was added dropwise until no solids were precipitated, filtered, the filtrate was allowed to stand for stratification, and organic The layer was washed with saturated brine and dried over anhydrous magnesium sulfate. After filtration, 0.5 g of activated carbon was added to the filtrate, and heated to reflux for half an hour. After removing the activated carbon, the filtrat...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a preparation method of Pranlukast intermediate with the structure as shown in the formula (II), the synthesis route of which is shown as follow. Compared with the prior art, the synthesis route couples the dehalogenate and the nitro group reduction steps, so the reaction process is simplified, the reaction condition is moderate, the post treatment is relatively simple, the reaction time is shortened, and the reaction yield is improved. The invention provides a novel practical synthesis method for synthesizing Pranlukast.

Description

technical field [0001] The present invention relates to a pranlukast intermediate whose structure is shown in formula (II), that is, 8-amino-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-4- Preparation method of ketone: [0002] Background technique [0003] The chemical name of Pranlukast is: 4-oxo-8-(4-(4-phenylbutoxy)benzamido)-2-(tetrazol-5-yl)-4H- 1-benzopyran, its structure is shown in formula (I): [0004] [0005] Pranlukast can be used in the treatment of asthma, allergic rhinitis and other diseases. The compound was first synthesized by Japan Ono Company, the compound patent EP0173516. [0006] Hisao N et al first reported the synthetic method of 8-amino-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-4-one on J.M.C, which introduced the synthesis method of 2- Hydroxy-3-nitroacetophenone is used as the starting material to condense with diethyl oxalate, cyclization and dehydration, to construct a benzopyran ring, pass through ammonia gas for amination, dehydration to cyanide...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07D405/04
Inventor 余长泉陈瀛杨健
Owner ZHEJIANG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com