Preparation method of calcium alginate microcapsule

Abstract

The invention discloses a preparation method of calcium alginate microcapsule, which comprises the following steps that: 1. sodium alga acid and polyethylene glycol with the average molecular weight of 200 to 1000 are dissolved into deionized water to prepare the sodium alga acid water solution which is used as a solution A, fatty acid calcium with the carbo-chain length of C5 to C11 is dissolved into alcohol solvent with the carbo-chain length of C2 to C11 or dissolved into aromatic solvent under the assistance of ethanol to prepare fatty acid calcium alcoholic solution or aromatic solution of fatty acid calcium which is used as a solution B. 2. The solution A is mixed with the solution B to prepare the calcium alginate microcapsule with the granularity being less than 50 micrometers. The raw materials are easy to obtain, the operation is simple, no particular equipment is required, and the calcium alginate microcapsule which can be used for embedding oil soluble medicine can be prepared without complicated processing procedures.

Description

technical field The invention belongs to the field of polymer compound preparation, and in particular relates to a preparation method of calcium alginate microcapsules. Background technique Alginic acid is a natural biological polysaccharide extracted from brown algae or bacteria. In terms of chemical structure, it is a G chain composed of a single Guluronic acid (Guluroni cacid, G), and its stereoisomer single mannuronic acid The M chain composed of Mannuronic acid (M), and the non-single-chain G-M chain composed of two uronic acids randomly alternating, the relative content of the three different chain structures is related to the source of alginic acid. Among them, the G chain can combine with multivalent cations such as calcium ions or barium ions to cause alginic acid to gel. Because alginate has a mild sol-gel process, good biocompatibility, and low cost, it is suitable as a microcapsule for embedding or releasing drugs, so it has been widely used in the fields of dru...

AI Technical Summary

Problems solved by technology

But because conventional preparation method is more loaded down with trivial details, for example needs to use various instruments to prepare microcapsule (Hyun-Ho Lee, J.Chem.Tech.Biotechnol., 1996,67,255-259), utilizes sound wave to prepare calcium alginate microcapsule Capsules (OlavBiomaterials., 1999, 20, P.774), the calcium alginate microcapsules were preliminarily prepared by a high-pressure microcapsule forming device and then secondary solidified (Keng-Shiang Huang, J.Micromech.Microeng., 2007, 17, P .1428-1430) etc.

The method disclosed in Chinese patent CN 1850058A for preparing calcium alginate microcapsules is to add sodium alginate aqueous solution into dichloromethane to form an emulsion, and then purify and solidify again. In this way, not only an additional emulsifier is used, but also further solidification and post-treatment are required. Difficult to operate

The preparation methods disclosed so far often cannot directly form a homogeneous or two-phase sodium alginate solution and a calcium salt solution to embed various oil-soluble drugs, and the calcium salts used in reports are limited to inorganic calcium salts

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