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Method for preparing organic iron supplement by using radix codonopsitis

A technology of iron supplement and Codonopsis pilosula, applied in the field of preparation of biological macromolecular metal complexes, can solve problems such as unfavorable digestion and absorption, allergic problems of patients, etc.

Inactive Publication Date: 2010-09-01
LANZHOU UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Iron dextran is used to treat iron deficiency anemia in patients with renal failure through intravenous infusion, which avoids gastrointestinal irritation and adverse digestion and absorption problems, but some patients have allergic problems

Method used

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  • Method for preparing organic iron supplement by using radix codonopsitis
  • Method for preparing organic iron supplement by using radix codonopsitis
  • Method for preparing organic iron supplement by using radix codonopsitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Weigh 100g of Codonopsis pilosula powder, put it in petroleum ether solution, and extract it under reflux at 75°C for 2 hours; then filter, and then use 95% ethanol to extract the residue under reflux at 85°C for 2 hours; filter, dry the filter residue, and weigh it. The degreased filter residue was extracted twice with distilled water at 100°C for 3 hours each time, then the water extracts were combined and centrifuged to remove the precipitate; the sevag method was used to remove the precipitate, and the centrifuged water extract was concentrated to 200ml, first add chloroform and then n-butanol, shake vigorously, and let it stand for 12 hours; centrifuge to remove the protein in the organic solvent layer and the water extract layer. The volume of the aqueous extract layer was collected, and the sevag solvent was added in proportion again. Repeat the above operations until there is no protein between the organic solvent layer and the aqueous extract layer. Concentrat...

Embodiment 2

[0023] The preparation of Codonopsis polysaccharide is the same as in Example 1.

[0024] Weigh 2g of Codonopsis polysaccharide, add a certain amount of deionized water to dissolve, and stir fully at 25°C to 40°C to fully dissolve it. Stir in a water bath at 60°C for about 5 minutes, add 20% sodium hydroxide solution during constant stirring, adjust the pH to 8, then slowly add ferric chloride dropwise, repeat the above operation, and control the pH to 8 , until the red-brown insoluble matter appears in the reaction, continue to heat in a 60°C water bath, stir for about 1 hour, stop stirring, centrifuge to remove the precipitate, collect the red-brown centrifugate, add a certain amount of absolute ethanol to the centrifuge, and keep stirring at the same time, After standing for 12 hours, the supernatant was poured off, and the precipitate was washed successively with anhydrous methanol, 95% ethanol, anhydrous ethanol, diethyl ether, and acetone, and then vacuum-dried at 50°C. ...

Embodiment 3

[0026] The preparation of Codonopsis polysaccharide is the same as in Example 1.

[0027] Weigh 2g of Codonopsis polysaccharide, add a certain amount of deionized water to dissolve, stir fully at 25°C to fully dissolve. Stir in a water bath at 80°C for about 5 minutes, add 20% sodium hydroxide solution to adjust pH = 8 during continuous stirring, then slowly add ferric chloride dropwise, repeat the above operation, control at pH = 8, Continue to heat in a water bath at 80°C until reddish-brown insoluble matter appears, and stir for about 1 hour. After stopping stirring, centrifuge to remove the precipitate, collect the reddish-brown centrifugate, add a certain amount of absolute ethanol to the centrifuge, and keep stirring at the same time, place After 12 hours, the supernatant was decanted, and the precipitate was washed successively with anhydrous methanol, 95% ethanol, anhydrous ethanol, diethyl ether, and acetone, and then vacuum-dried at 50°C. As a result, the content of...

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Abstract

The invention discloses a method for preparing an organic iron supplement by using radix codonopsitis. The method comprises the following steps of: degreasing coarse radix codonopsitis powder; extracting the degreased radix codonopsitis powder by using water; filtering and condensing under a reduced pressure; removing protein in a concentrate; adding absolute ethanol into a container in which the concentrate is held for performing alcohol precipitation; after the alcohol precipitation, washing precipitate with the absolute ethanol; drying the washed precipitate in vacuum to obtain radix codonopsitis polysaccharide; dissolving the radix codonopsitis polysaccharide in de-ionized water; stirring the dissolved radix codonopsitis polysaccharide at the temperature of between 25 and 40 DEG C; heating to the temperature of between 60 and 80 DEG C; adding sodium hydroxide into the solution with continuous stirring; regulating pH to be 7 to 9; adding the solution of ferric trichloride and stopping adding alkali liquor and ferric trichloride until reddish brown undissolved substance appears; continuing the reaction for 1 hour with stirring; performing centrifugal separation; collecting centrifugate; adding the absolute ethanol into the centrifugate; standing and precipitating for 12 hours; washing the precipitate with absolute methanol, 95 percent ethanol, absolute ethanol, ethyl ether and acetone respectively; and placing the precipitate in vacuum for drying to obtain radix codonopsitis polyferose.

Description

technical field [0001] The invention relates to a preparation method of a biomacromolecular metal complex. Background technique [0002] Iron dextran and iron gluconate have been widely used in the United States since the 1990s. Iron dextran is used to treat iron deficiency anemia in patients with renal failure through intravenous infusion, which avoids gastrointestinal irritation and adverse digestion and absorption problems, but some patients have allergic problems. Since the immunomodulatory effect of polysaccharides has been fully revealed, the compound blood enriching preparation with ferric iron as the core and polysaccharide as the complex has become a new type of oral iron supplementation preparation. The polysaccharide iron has few side effects, stable compatibility, good solubility, proper coordination stability, and no or little stimulation to the gastrointestinal tract. [0003] Codonopsis pilosula mainly contains active ingredients such as polysaccharides and ...

Claims

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Application Information

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IPC IPC(8): A61K36/344A61P3/02C08B37/00
Inventor 张新国米世涛曾艳龙陈文洁
Owner LANZHOU UNIVERSITY OF TECHNOLOGY
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