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Injectable active bone repair material

A bone repair and injection type technology, applied in the field of medical devices, can solve the problems of low bioavailability, diffusion dilution, etc., and achieve the effects of good injectability, good stability and high safety

Active Publication Date: 2010-09-01
SHENZHEN LANDO BIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the main difficulty in clinical application of BMP is that it is easy to diffuse and dilute in the body, and its bioavailability is extremely low.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Embodiment 1, injectable active bone repair material

[0039] Preparation of bone-loaded growth factor BMP-2 microspheres:

[0040] (1). Solution preparation: prepare 100ml of 3% PLA solution and 100ml of 15μg / ml BMP-2 solution;

[0041] (2). Feeding: Put the PLA solution and BMP-2 solution prepared in (1) into the ultrasonic atomization generator through a syringe pump at a flow rate of 0.2mL / min and 1mL / min, respectively;

[0042] (3). Atomization: use 60kHz atomization vibration frequency to generate micro-droplets;

[0043] (4). Solvent volatilization: collect the micro-droplets produced in (3) with 0.1% PVA aqueous solution, and continue mechanical stirring for 4 hours to volatilize dichloromethane;

[0044] (5). Wash and freeze-dry, set aside;

[0045] Preparation of injectable active bone repair materials:

[0046] (1). Mix 10mg bone-loaded growth factor BMP-2 microspheres with 0.5g amorphous calcium phosphate, 4.5g tetracalcium phosphate, 3.5gβ-tricalcium ph...

Embodiment 2

[0048] Embodiment 2, injectable active bone repair material

[0049] Preparation of bone-loaded growth factor BMP-2 microspheres:

[0050] (1). Solution preparation: prepare 100ml of 2% PLGA solution and 100ml of 20μg / ml BMP-2 solution;

[0051] (2). Feeding: Add the PLGA solution and BMP-2 solution prepared in (1) into the ultrasonic atomization generator through a syringe pump at a flow rate of 0.2mL / min and 1mL / min, respectively;

[0052](3). Atomization: use 60kHz atomization vibration frequency to generate micro-droplets;

[0053] (4). Solvent volatilization: collect the micro-droplets produced in (3) with 0.1% PVA aqueous solution, and continue mechanical stirring for 4 hours to volatilize dichloromethane;

[0054] (5). Wash and freeze-dry, set aside;

[0055] Preparation of injectable active bone repair materials:

[0056] (1). Mix 12 mg of bone-loaded growth factor BMP-2 microspheres with 4 g of tetracalcium phosphate, 3.5 g of calcium hydrogen phosphate dihydrate,...

Embodiment 3

[0058] Embodiment 3, injectable active bone repair material

[0059] Preparation of bone-loaded growth factor BMP-7 microspheres:

[0060] (1). Solution preparation: prepare 100ml of 5% PLGA solution and 30μg / ml BMP-7 solution ml;

[0061] (2). Feeding: Add the PLGA solution and BMP-7 solution prepared in (1) into the ultrasonic atomization generator through the syringe pump at a flow rate of 0.2mL / min and 1mL / min, respectively;

[0062] (3). Atomization: use 60kHz atomization vibration frequency to generate micro-droplets;

[0063] (4). Solvent volatilization: collect the micro-droplets produced in (3) with 0.1% PVA aqueous solution, and continue mechanical stirring for 4 hours to volatilize dichloromethane;

[0064] (5). Wash and freeze-dry, set aside;

[0065] Preparation of injectable active bone repair materials:

[0066] (1). Stir 5mg of bone-loaded growth factor BMP-7 microspheres with 3g of tetracalcium phosphate, 4g of β-tricalcium phosphate, 1.5g of α-calcium sul...

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PUM

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Abstract

The invention relates to an injectable active bone repair material. The material has good liquidity, can reach a bone defect part through injection and quickly solidify the defect part, and can obviously promote the healing of bone trauma along with gradual release of rear bone growth factors so as to shorten the healing period. Main components of the injectable active bone repair material consist of multiple calcium salts such as phosphoric acid calcium salt, calcium sulfate, calcium carbonate and the like, stowage factor microspheres and solidifying conditioner. The injectable active bone repair material has good injectability and collapse resistance. The solidifying time is 15 to 30 minutes, the temperature rise is not over 45 DEG C during solidifying, and the material does not cause adverse effect on tissues of an implanted part. After solidifying for half an hour, the material reaches the strength of spongy bone. All the components of the material are medicinal raw materials approved by the United States Food and Drug Administration, and can meet the safety of clinical use.

Description

technical field [0001] The invention belongs to the field of medical equipment, more precisely, the invention relates to an injectable active bone repair material. technical background [0002] With the development of minimally invasive surgical techniques, injectable bone repair materials have become a kind of bone tissue regeneration and repair materials that are urgently needed in clinical practice. , greatly reducing the pain of patients and other advantages and much attention, broad application prospects. In addition, bone morphogenetic protein (BMP), also known as bone growth factor, can increase the expression of genes such as alkaline phosphatase and osteocalcin, the marker enzymes of osteoblast differentiation, and promote new bone formation and bone growth. Hierarchy plays a key role in the process of osteoblast differentiation, among which BMP-7 and BMP-2 have the strongest ability to induce osteogenesis (J Bone Joint Surg Am, 2007, 89(3):649-658). BMP has the a...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L27/02A61L27/54A61L27/50
Inventor 佘振定谭荣伟王明波
Owner SHENZHEN LANDO BIOMATERIALS
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