Novel in situ liquid crystal vascular embolization agent
A vascular embolizing agent and in-situ liquid crystal technology, which is applied in the field of in-situ liquid crystal vascular embolic agents and vascular embolizing agents for interventional therapy, can solve the problems of difficulty in preparation, strict requirements on phase transition temperature, etc.
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Embodiment 1
[0018] The preparation of the in-situ liquid crystal vascular embolism described in this example is as follows: Weigh 1.2 g of absolute ethanol and 3.2 g of phytantriol, vortex and mix both, add 0.5 g of water, vortex mix, and centrifuge to obtain a clear Liquid embolic agents.
[0019] New Zealand rabbits were anesthetized by ear vein injection with 0.2ml / kg Sumianxin. After the rabbits were anesthetized for 5 to 10 minutes, they were placed on the self-made fixing board, and the board was placed on the DSA operating table. The right groin Hair removal and disinfection, sterile surgical drape, incision of the groin skin, separation to the femoral arteriovenous sheath layer by layer, intermittent spraying of lidocaine, exposure of the right femoral artery and hemostatic forceps to separate and expose the femoral artery, both ends covered with silk thread , Lift both ends of the silk thread to separate the femoral artery from the surrounding tissue. Then puncture the femoral a...
Embodiment 2
[0021] The preparation of the in-situ liquid crystal vascular embolization agent described in this example is as follows: Weigh 1.2 g of absolute ethanol and 3.2 g of phytantriol, vortex and mix both, add 1 g of water, vortex mix, and centrifuge to obtain a clarified Liquid embolic agents.
[0022] The obtained liquid embolic agent is vortex-mixed with 1 g of lipiodolized oil to obtain a contrastable liquid embolic agent. The resulting contrastable liquid embolic agent is used to embolize the hepatic arteries of rabbits (method is the same as in Example 1), as figure 2 As shown, it has developing and embolic effects.
Embodiment 3
[0024] Establish VX2 liver cancer tumor-bearing rabbits.
[0025] The preparation of the in-situ liquid crystal vascular embolization agent described in this example is as follows: Weigh 1.8 g of absolute ethanol, add 5 mg of docetaxel, and then add 2.7 g of glycerol monooleate, vortex and mix the two (slightly heated), Add 0.5g of water, vortex mix (slightly heated), and centrifuge to obtain a clear liquid embolism.
[0026] After the liquid embolic agent of gained is added 3g iodized oil, rabbit is carried out hepatic artery embolization (method is the same as embodiment 1), observes tumor volume change under CT, see image 3 (with the normal saline group as the control), the results show that the in situ liquid crystal blood vessel embolization agent can effectively inhibit tumor growth. In addition, there was no tube blockage during the experiment, and the animals moved normally.
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