Composite matrix gel vascular embolization agent as well as preparation method and application thereof

A technology of vascular embolism and composite matrix, which is applied in the fields of medical science and surgery, can solve the problems that the embolization effect is not completely reliable, and cannot continue to exert the embolism function, so as to achieve the long-lasting vascular embolism function, the exact therapeutic effect, and overcome the instability. Effect

Active Publication Date: 2015-05-27
贺欣
View PDF7 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, alginate microspheres have the disadvantage of being unstable, that is, they are completely dissociated into a solution state in the presence of phosphate ions, hydrogen phosphate ions, carbonate ions, and citrate ions. In the solution of sodium ions and pH>7.4 Significant swelling or even dissociation occurs, and the embolic function cannot be continuously performed, resulting in an unreliable embolic effect

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1 and comparative example:

[0023] (1) Chitosan is formulated into an aqueous solution with a concentration of 10g / L, and sodium alginate is formulated with a 25g / L aqueous solution.

[0024] (2) Mix the two solutions prepared in step (1) in equal proportions, stir evenly, filter aseptically, and set aside.

[0025] (3) The mixed solution prepared in step (2) is passed through the electrostatic droplet method to put the monodisperse droplet in the CaCl concentration of 11g / L 2 A gelation reaction occurs in the solution. After 2 hours of gelation, use 5g / L of CaCl 2 The solution is washed repeatedly to obtain composite matrix gel microspheres with particle diameters uniformly distributed at 300 microns.

[0026] (4) Sodium alginate is formulated into an aqueous solution with a concentration of 15g / L, and after sterile filtration, monodisperse sodium alginate droplets are added to CaCl with a concentration of 11g / L by electrostatic droplet method. 2 A gelat...

Embodiment 2

[0033] Embodiment 2 and comparative example:

[0034] (1) Chitosan is formulated into an aqueous solution with a concentration of 10g / L, and sodium alginate is formulated with a 25g / L aqueous solution.

[0035] (2) Mix the two solutions prepared in step (1) in equal proportions, stir evenly, filter aseptically, and set aside.

[0036] (3) The mixed solution prepared in step (2) is passed through the electrostatic droplet method to put the monodisperse droplet in the CaCl concentration of 11g / L 2 A gelation reaction occurs in the solution. After 2 hours of gelation, use 5g / L of CaCl 2 The solution is washed repeatedly to obtain composite matrix gel microspheres with particle diameters uniformly distributed at 500 microns.

[0037] (4) Sodium alginate was prepared into an aqueous solution with a concentration of 15 g / L, which was sterile filtered and set aside.

[0038] (5) Prepare 11g / L of CaCl 2 solution, and adjust the pH to 5.5 with hydrochloric acid, set aside.

[0039...

Embodiment 3

[0042] Embodiment 3 tumor patient clinical application:

[0043] Volunteer patient: Ma XX, male, 80 years old, clinical diagnosis: malignant tumor of the left renal pelvis, hematuria (++++), hemoglobin 3.0, residual 5% of left renal function. The right side is 25%, the general condition is poor, surgery and chemotherapy cannot be performed, blood transfusion cannot be used for emergency treatment, and the patient is reported as critically ill.

[0044] Preparation of composite matrix gel microspheres:

[0045] (1) Chitosan is prepared into an aqueous solution with a concentration of 20 g / L, and sodium alginate is prepared with a 25 g / L aqueous solution, which are sterile filtered respectively and set aside.

[0046] (2) Mix the two solutions prepared in step (1) in equal proportions, stir aseptically evenly, and set aside.

[0047] (3) The mixed solution prepared in step (2) is passed through the electrostatic droplet method, and the monodisperse droplet is subjected to a ge...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
molecular weightaaaaaaaaaa
molecular weightaaaaaaaaaa
particle diameteraaaaaaaaaa
Login to view more

Abstract

The invention belongs to the field of medical embolization equipment, and relates to a composite matrix gel vascular embolization agent and a preparation method thereof. According to the composite matrix gel vascular embolization agent, alginate and chitosan are taken as preparation materials of a gel; by adopting a composite matrix hydrogel, the problems that a pure calcium alginate microsphere embolization agent is unstable at a blood plasma environment, is easy to break, and can cause short embolization effect maintaining time can be solved; and the composite matrix hydrogel prepared from sodium alginate and chitosan can be used for stabilizing the strength of the gel in blood vessels, can be taken as a vascular embolization agent to exert continuous vascular embolization functions, has high efficiency and low toxicity, can be clinically applied, and also is safe and effective. The composite matrix gel vascular embolization agent disclosed by the invention is mild in preparation condition and simple and convenient to operate, is suitable for scale production, can be applied to vascular embolization, can be applied to local targeted therapy of tumors such as liver cancer, kidney cancer, small cell lung cancer, ovarian cancer and testicular cancer, and can also be used for treating hyperthyroidism diseases and internal hemorrhage diseases.

Description

technical field [0001] The invention relates to the application of a composite matrix gel, in particular to the application of the composite matrix gel in blood vessel embolism. Background technique [0002] Intervention therapy is a new treatment method developed in the 1970s. Transcatheter arterial embolization (TCAE) is an important technique in interventional therapy. It is a controllable injection of artificial embolic materials into the feeding vessels of lesions or organs or into diseased blood vessels through interventional arterial catheterization, so that Occlusion interrupts the blood supply to achieve the purpose of controlling bleeding, treating vascular lesions, cutting off the blood supply and nutrition of tumors, and eliminating the function of diseased organs. In TCAE, in addition to placing the catheter in the corresponding position, the choice of embolic material plays an important role in the success of the treatment. An ideal embolic material should be...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/04A61L31/14C08J3/24
Inventor 贺欣
Owner 贺欣
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap